PMID- 26061809
OWN - NLM
STAT- MEDLINE
DCOM- 20160609
LR  - 20171116
IS  - 1097-0339 (Electronic)
IS  - 1097-0339 (Linking)
VI  - 43
IP  - 9
DP  - 2015 Sep
TI  - Cytomorphology and immunohistochemistry of a recurrent clear cell odontogenic 
      carcinoma with molecular analysis: A case report with review of literature.
PG  - 743-6
LID - 10.1002/dc.23297 [doi]
AB  - Clear cell odontogenic carcinoma (CCOC) is a rare, odontogenic tumor of the jaws 
      with mandibular involvement usually present in sixth decade of life with female 
      preponderance. It is classified as a malignant tumor of odontogenic origin in 
      2005 by the World Health Organization because of its aggressive and destructive 
      growth capacity and potential to metastasize. It needs to be distinguished from 
      other primary and metastatic clear cell tumors of the oral and maxillofacial 
      region. Recently, CCOCs have been noted to harbor a Ewing sarcoma breakpoint 
      region 1 gene RNA-binding protein 1 (EWSR1) and activating transcription factor 
      (ATF) gene translocation. To date, cytologic features of only one case have been 
      reported in the literature. We report an additional case of 55-year-old woman 
      with enlarging mass in the left mandible. This report describes cytologic and 
      immunohistochemical features of CCOC with positive EWSR1 gene rearrangements by 
      fluorescence in situ hybridization (FISH). As diagnosis of CCOC is challenging on 
      fine-needle aspiration, immunohistochemistry and FISH analysis are very useful 
      diagnostic tool in clear cell lesions of mandible.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Harbhajanka, Aparna
AU  - Harbhajanka A
AD  - Department of Pathology, Rush University Medical Center, Chicago, Illinois.
FAU - Lamzabi, Ihab
AU  - Lamzabi I
AD  - Department of Pathology, Rush University Medical Center, Chicago, Illinois.
FAU - Jain, Richa
AU  - Jain R
AD  - Department of Pathology, Rush University Medical Center, Chicago, Illinois.
FAU - Gattuso, Paolo
AU  - Gattuso P
AD  - Department of Pathology, Rush University Medical Center, Chicago, Illinois.
FAU - Kluskens, Larry
AU  - Kluskens L
AD  - Department of Pathology, Rush University Medical Center, Chicago, Illinois.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20150610
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
RN  - 0 (Calmodulin-Binding Proteins)
RN  - 0 (EWSR1 protein, human)
RN  - 0 (RNA-Binding Protein EWS)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Adenocarcinoma, Clear Cell/*diagnosis/genetics/pathology
MH  - Biopsy, Fine-Needle
MH  - Calmodulin-Binding Proteins/*genetics
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Mandible/pathology
MH  - Mandibular Neoplasms/*diagnosis/genetics/pathology
MH  - Middle Aged
MH  - Odontogenic Tumors/*diagnosis/genetics/pathology
MH  - RNA-Binding Protein EWS
MH  - RNA-Binding Proteins/*genetics
OTO - NOTNLM
OT  - EWS RNA-binding protein 1
OT  - clear cell odontogenic carcinoma
OT  - odontogenic carcinoma
EDAT- 2015/06/11 06:00
MHDA- 2016/06/10 06:00
CRDT- 2015/06/11 06:00
PHST- 2014/12/29 00:00 [received]
PHST- 2015/03/27 00:00 [revised]
PHST- 2015/04/09 00:00 [accepted]
PHST- 2015/06/11 06:00 [entrez]
PHST- 2015/06/11 06:00 [pubmed]
PHST- 2016/06/10 06:00 [medline]
AID - 10.1002/dc.23297 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2015 Sep;43(9):743-6. doi: 10.1002/dc.23297. Epub 2015 Jun 10.