PMID- 26063468
OWN - NLM
STAT- MEDLINE
DCOM- 20151217
LR  - 20220317
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 63
IP  - 26
DP  - 2015 Jul 8
TI  - Effects of D-Pinitol on Insulin Resistance through the PI3K/Akt Signaling Pathway 
      in Type 2 Diabetes Mellitus Rats.
PG  - 6019-26
LID - 10.1021/acs.jafc.5b01238 [doi]
AB  - D-pinitol, a compound isolated from Pinaceae and Leguminosae plants, has been 
      reported to possess insulin-like properties. Although the hypoglycemic activity 
      of D-pinitol was recognized in recent years, the molecular mechanism of D-pinitol 
      in the treatment of diabetes mellitus remains unclear. In this investigation, a 
      model of type 2 diabetes mellitus (T2DM) with insulin resistance was established 
      by feeding a high-fat diet (HFD) and injecting streptozocin (STZ) to 
      Sprague-Dawley (SD) rats, targeting the exploration of more details of the 
      mechanism in the therapy of T2DM. D-pinitol was administrated to the diabetic 
      rats as two doses [30, 60 mg/(kg.body weight.day)]. The level of fasting blood 
      glucose (FBG) was decreased 12.63% in the high-dosage group, and the ability of 
      oral glucose tolerance was improved in D-pinitol-treated groups. The biochemical 
      indices revealed that D-pinitol had a positive effect on hypoglycemic activity. 
      Western boltting suggested that D-pinitol could promote the expression of the 
      phosphatidylinositol-3-kinase (PI3K) p85, PI3Kp110, as well as the downstream 
      target protein kinase B/Akt (at Ser473). Besides, D-pinitol inhibited the 
      expression of glycogen synthesis kinase-3beta (GSK-3beta) protein and regulated the 
      expression of glycogen synthesis (GS) protein and then accelerated the glycogen 
      synthesis. Above all, D-pinitol played a positive role in regulating 
      insulin-mediated glucose uptake in the liver through translocation and activation 
      of the PI3K/Akt signaling pathway in T2DM rats.
FAU - Gao, Yunfeng
AU  - Gao Y
FAU - Zhang, Mengna
AU  - Zhang M
FAU - Wu, Tianchen
AU  - Wu T
FAU - Xu, Mengying
AU  - Xu M
FAU - Cai, Haonan
AU  - Cai H
FAU - Zhang, Zesheng
AU  - Zhang Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150623
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Blood Glucose)
RN  - 0 (Plant Extracts)
RN  - 484-68-4 (pinitol)
RN  - 4L6452S749 (Inositol)
RN  - EC 2.7.1.137 (Phosphatidylinositol 3-Kinase)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.26 (Glycogen Synthase Kinase 3)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/*drug therapy/enzymology/genetics/metabolism
MH  - Fabaceae/*chemistry
MH  - Glucose Tolerance Test
MH  - Glycogen Synthase Kinase 3/genetics/metabolism
MH  - Humans
MH  - Inositol/administration & dosage/*analogs & derivatives
MH  - *Insulin Resistance
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Phosphatidylinositol 3-Kinase/genetics/*metabolism
MH  - Pinaceae/*chemistry
MH  - Plant Extracts/*administration & dosage/chemistry
MH  - Proto-Oncogene Proteins c-akt/genetics/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/*drug effects
OTO - NOTNLM
OT  - PI3K/Akt signaling pathway
OT  - d-pinitol
OT  - diabetes mellitus
EDAT- 2015/06/13 06:00
MHDA- 2015/12/19 06:00
CRDT- 2015/06/12 06:00
PHST- 2015/06/12 06:00 [entrez]
PHST- 2015/06/13 06:00 [pubmed]
PHST- 2015/12/19 06:00 [medline]
AID - 10.1021/acs.jafc.5b01238 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2015 Jul 8;63(26):6019-26. doi: 10.1021/acs.jafc.5b01238. Epub 
      2015 Jun 23.