PMID- 26064103
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150611
LR  - 20220310
IS  - 1687-6334 (Print)
IS  - 1687-6342 (Electronic)
IS  - 1687-6334 (Linking)
VI  - 2015
DP  - 2015
TI  - Anti-Inflammatory Effects of Heparin and Its Derivatives: A Systematic Review.
PG  - 507151
LID - 10.1155/2015/507151 [doi]
LID - 507151
AB  - Background. Heparin, used clinically as an anticoagulant, also has 
      anti-inflammatory properties. The purpose of this systematic review was to 
      provide a comprehensive review regarding the efficacy and safety of heparin and 
      its derivatives as anti-inflammatory agents. Methods. We searched the following 
      databases up to March 2012: Pub Med, Scopus, Web of Science, Ovid, Elsevier, and 
      Google Scholar using combination of Mesh terms. Randomized Clinical Trials (RCTs) 
      and trials with quasi-experimental design in clinical setting published in 
      English were included. Quality assessments of RCTs were performed using Jadad 
      score and Consolidated Standards of Reporting Trials (CONSORT) checklist. 
      Results. A total of 280 relevant studies were reviewed and 57 studies met the 
      inclusion criteria. Among them 48 studies were RCTs. About 65% of articles had 
      score of 3 and higher according to Jadad score. Twelve studies had a quality 
      score > 40% according to CONSORT items. Asthma (n = 7), inflammatory bowel 
      disease (n = 5), cardiopulmonary bypass (n = 8), and cataract surgery (n = 6) 
      were the most studied disease condition. Forty studies use unfractionated heparin 
      (UFH) for intervention; the remaining studies use low molecular weight heparin 
      (LMWH). Conclusion. Despite the conflicting results, heparin seems to be a safe 
      and effective anti-inflammatory agent; although it is shown that heparin can 
      decrease the level of inflammatory biomarkers and improves patient conditions, 
      still more data from larger rigorously designed studies are needed to support use 
      of heparin as an anti-inflammatory agent in clinical setting. However, because of 
      the association between inflammation, atherogenesis, thrombogenesis, and cell 
      proliferation, heparin and related compounds with pleiotropic effects may have 
      greater therapeutic efficacy than compounds acting against a single target.
FAU - Mousavi, Sarah
AU  - Mousavi S
AD  - Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy and 
      Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Moradi, Mandana
AU  - Moradi M
AD  - Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.
FAU - Khorshidahmad, Tina
AU  - Khorshidahmad T
AD  - Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Motamedi, Maryam
AU  - Motamedi M
AD  - Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150512
PL  - United States
TA  - Adv Pharmacol Sci
JT  - Advances in pharmacological sciences
JID - 101537654
PMC - PMC4443644
EDAT- 2015/06/13 06:00
MHDA- 2015/06/13 06:01
PMCR- 2015/05/12
CRDT- 2015/06/12 06:00
PHST- 2015/02/24 00:00 [received]
PHST- 2015/04/24 00:00 [accepted]
PHST- 2015/06/12 06:00 [entrez]
PHST- 2015/06/13 06:00 [pubmed]
PHST- 2015/06/13 06:01 [medline]
PHST- 2015/05/12 00:00 [pmc-release]
AID - 10.1155/2015/507151 [doi]
PST - ppublish
SO  - Adv Pharmacol Sci. 2015;2015:507151. doi: 10.1155/2015/507151. Epub 2015 May 12.