PMID- 26064426
OWN - NLM
STAT- MEDLINE
DCOM- 20160329
LR  - 20220330
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2015
DP  - 2015
TI  - New Insights for Oxidative Stress and Diabetes Mellitus.
PG  - 875961
LID - 10.1155/2015/875961 [doi]
LID - 875961
AB  - The release of reactive oxygen species (ROS) and the generation of oxidative 
      stress are considered critical factors for the pathogenesis of diabetes mellitus 
      (DM), a disorder that is growing in prevalence and results in significant 
      economic loss. New therapeutic directions that address the detrimental effects of 
      oxidative stress may be especially warranted to develop effective care for the 
      millions of individuals that currently suffer from DM. The mechanistic target of 
      rapamycin (mTOR), silent mating type information regulation 2 homolog 1 (S. 
      cerevisiae) (SIRT1), and Wnt1 inducible signaling pathway protein 1 (WISP1) are 
      especially justified to be considered treatment targets for DM since these 
      pathways can address the complex relationship between stem cells, trophic 
      factors, impaired glucose tolerance, programmed cell death pathways of apoptosis 
      and autophagy, tissue remodeling, cellular energy homeostasis, and vascular 
      biology that greatly impact the biology and disease progression of DM. The 
      translation and development of these pathways into viable therapies will require 
      detailed understanding of their proliferative nature to maximize clinical 
      efficacy and limit adverse effects that have the potential to lead to unintended 
      consequences.
FAU - Maiese, Kenneth
AU  - Maiese K
AUID- ORCID: 0000-0002-5049-9116
AD  - Laboratory of Cellular and Molecular Signaling, Newark, NJ 07101, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, American Recovery and Reinvestment Act
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150512
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (CCN Intercellular Signaling Proteins)
RN  - 0 (CCN4 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - Autophagy
MH  - CCN Intercellular Signaling Proteins/metabolism
MH  - Diabetes Mellitus/metabolism/*pathology
MH  - Humans
MH  - *Oxidative Stress
MH  - Proto-Oncogene Proteins/metabolism
MH  - Signal Transduction
MH  - Sirtuin 1/metabolism
MH  - TOR Serine-Threonine Kinases/metabolism
PMC - PMC4443788
EDAT- 2015/06/13 06:00
MHDA- 2016/03/30 06:00
PMCR- 2015/05/12
CRDT- 2015/06/12 06:00
PHST- 2014/11/30 00:00 [received]
PHST- 2015/04/15 00:00 [accepted]
PHST- 2015/06/12 06:00 [entrez]
PHST- 2015/06/13 06:00 [pubmed]
PHST- 2016/03/30 06:00 [medline]
PHST- 2015/05/12 00:00 [pmc-release]
AID - 10.1155/2015/875961 [doi]
PST - ppublish
SO  - Oxid Med Cell Longev. 2015;2015:875961. doi: 10.1155/2015/875961. Epub 2015 May 
      12.