PMID- 26064945
OWN - NLM
STAT- MEDLINE
DCOM- 20160310
LR  - 20220409
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2015
DP  - 2015
TI  - Insulin Resistance-Associated Interhemispheric Functional Connectivity 
      Alterations in T2DM: A Resting-State fMRI Study.
PG  - 719076
LID - 10.1155/2015/719076 [doi]
LID - 719076
AB  - We aim to investigate whether decreased interhemispheric functional connectivity 
      exists in patients with type 2 diabetes mellitus (T2DM) by using resting-state 
      functional magnetic resonance imaging (rs-fMRI). In addition, we sought to 
      determine whether interhemispheric functional connectivity deficits associated 
      with cognition and insulin resistance (IR) among T2DM patients. We compared the 
      interhemispheric resting state functional connectivity of 32 T2DM patients and 30 
      healthy controls using rs-fMRI. Partial correlation coefficients were used to 
      detect the relationship between rs-fMRI information and cognitive or clinical 
      data. Compared with healthy controls, T2DM patients showed bidirectional 
      alteration of functional connectivity in several brain regions. Functional 
      connectivity values in the middle temporal gyrus (MTG) and in the superior 
      frontal gyrus were inversely correlated with Trail Making Test-B score of 
      patients. Notably, insulin resistance (log homeostasis model assessment-IR) 
      negatively correlated with functional connectivity in the MTG of patients. In 
      conclusion, T2DM patients exhibit abnormal interhemispheric functional 
      connectivity in several default mode network regions, particularly in the MTG, 
      and such alteration is associated with IR. Alterations in interhemispheric 
      functional connectivity might contribute to cognitive dysfunction in T2DM 
      patients.
FAU - Xia, Wenqing
AU  - Xia W
AD  - Medical School of Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, 
      China ; Center for Functional Neuroimaging, University of Pennsylvania, 3710 
      Hamilton Walk, Philadelphia, PA 19104, USA.
FAU - Wang, Shaohua
AU  - Wang S
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      No. 87 Dingjiaqiao Road, Nanjing 210009, China.
FAU - Spaeth, Andrea M
AU  - Spaeth AM
AD  - Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, 
      University of Pennsylvania, 3710 Hamilton Walk, Philadelphia, PA 19104, USA.
FAU - Rao, Hengyi
AU  - Rao H
AD  - Center for Functional Neuroimaging, University of Pennsylvania, 3710 Hamilton 
      Walk, Philadelphia, PA 19104, USA.
FAU - Wang, Pin
AU  - Wang P
AD  - Medical School of Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, 
      China.
FAU - Yang, Yue
AU  - Yang Y
AD  - Medical School of Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, 
      China.
FAU - Huang, Rong
AU  - Huang R
AD  - Medical School of Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, 
      China.
FAU - Cai, Rongrong
AU  - Cai R
AD  - Medical School of Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, 
      China.
FAU - Sun, Haixia
AU  - Sun H
AD  - Medical School of Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, 
      China.
LA  - eng
GR  - T32 HL007713/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150430
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Mapping
MH  - Cognition Disorders/*diagnostic imaging/etiology/physiopathology
MH  - Diabetes Mellitus, Type 2/complications/*diagnostic imaging/physiopathology
MH  - Female
MH  - Frontal Lobe/diagnostic imaging/physiopathology
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Radiography
MH  - Temporal Lobe/diagnostic imaging/physiopathology
PMC - PMC4430652
EDAT- 2015/06/13 06:00
MHDA- 2016/03/11 06:00
PMCR- 2015/04/30
CRDT- 2015/06/12 06:00
PHST- 2015/02/16 00:00 [received]
PHST- 2015/04/16 00:00 [accepted]
PHST- 2015/06/12 06:00 [entrez]
PHST- 2015/06/13 06:00 [pubmed]
PHST- 2016/03/11 06:00 [medline]
PHST- 2015/04/30 00:00 [pmc-release]
AID - 10.1155/2015/719076 [doi]
PST - ppublish
SO  - Biomed Res Int. 2015;2015:719076. doi: 10.1155/2015/719076. Epub 2015 Apr 30.