PMID- 26065570
OWN - NLM
STAT- MEDLINE
DCOM- 20160808
LR  - 20181202
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1428
DP  - 2016 Jan 8
TI  - Aluminum based metal-organic framework-polymer monolith in solid-phase 
      microextraction of penicillins in river water and milk samples.
PG  - 236-45
LID - S0021-9673(15)00753-0 [pii]
LID - 10.1016/j.chroma.2015.05.043 [doi]
AB  - In this study, aluminum based metal-organic framework (Al-MOF)-organic polymer 
      monoliths were prepared via microwave-assisted polymerization of ethylene 
      dimethacrylate (EDMA), butyl methacrylate (BMA) with different weight percentages 
      of Al-MOF (MIL-53; 37.5-62.5%) and subsequently utilized as sorbent in 
      solid-phase microextraction (SPME) of penicillins (penicillin G, penicillin V, 
      oxacillin, cloxacillin, dicloxacillin, nafcillin). The Al-MOF-polymer was 
      characterized using Fourier transform infrared (FTIR) spectroscopy, powder X-ray 
      diffraction (XRD), scanning electron microscopy (SEM) and SEM-energy-dispersive 
      X-ray spectroscopy (SEM-EDS) to clarify the retained crystalline structure well 
      as the homogeneous dispersion of Al-MOF (MIL-53) in polymer monolith. The 
      developed Al-MOF-polymer (MIL-53) monolithic column was evaluated according to 
      its extraction recovery of penicillins. Several parameters affecting the 
      extraction recoveries of penicillins using fabricated Al-MOF-polymer (MIL-53) 
      monolithic column including different MIL-53 weight percentages, column length, 
      pH, desorption solvent, and mobile phase flow rate were investigated. For 
      comparison, different Al-based MOFs (MIL-68, CYCU-4 and DUT-5) were fabricated 
      using the optimized condition for MIL-53-polymer (sample matrix at pH 3, 200muL 
      desorption volume using methanol, 37.5% of MOF, 4-cm column length at 
      0.100mLmin(-1) flow rate). Among all the Al-MOF-polymers, MIL-53(Al)-polymer 
      still afforded the best extraction recovery for penicillins ranging from 90.5 to 
      95.7% for intra-day with less than 3.5% relative standard deviations (RSDs) and 
      inter-day precision were in the range of 90.7-97.6% with less than 4.2% RSDs. 
      Meanwhile, the recoveries for column-to-column were in the range of 89.5-93.5% 
      (<3.4% RSDs) while 88.5-90.5% (<5.8% RSDs) for batch-to-batch (n=3). Under the 
      optimal conditions, the limit of detections were in the range of 0.06-0.26mugL(-1) 
      and limit of quantifications between 0.20 and 0.87mugL(-1). Finally, the 
      MIL-53-polymer was applied for the extraction of penicillin in river water and 
      milk by spiking trace-level penicillin for as low as 50mugL(-1) and 100mugL(-1) 
      with recoveries ranging from 80.8% to 90.9% (<6.7% RSDs) in river water and 81.1% 
      to 100.7% (<7.1% RSDs) in milk sample, respectively.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Lirio, Stephen
AU  - Lirio S
AD  - Department of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, 
      Chung Li, Taoyuan 320, Taiwan.
FAU - Liu, Wan-Ling
AU  - Liu WL
AD  - Department of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, 
      Chung Li, Taoyuan 320, Taiwan.
FAU - Lin, Chen-Lan
AU  - Lin CL
AD  - Department of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, 
      Chung Li, Taoyuan 320, Taiwan.
FAU - Lin, Chia-Her
AU  - Lin CH
AD  - Department of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, 
      Chung Li, Taoyuan 320, Taiwan. Electronic address: chiaher@cycu.edu.tw.
FAU - Huang, Hsi-Ya
AU  - Huang HY
AD  - Department of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, 
      Chung Li, Taoyuan 320, Taiwan. Electronic address: hyhuang@cycu.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150527
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Methacrylates)
RN  - 0 (Penicillins)
RN  - 0 (Polymers)
RN  - 7BK5G69305 (ethylene dimethacrylate)
RN  - CPD4NFA903 (Aluminum)
RN  - R5QX287XXU (butyl methacrylate)
SB  - IM
MH  - Aluminum/*chemistry
MH  - Animals
MH  - Environmental Monitoring/*methods
MH  - Food Analysis/*methods
MH  - Methacrylates/chemistry
MH  - Milk/*chemistry
MH  - Penicillins/*analysis
MH  - Polymerization
MH  - Polymers/*chemistry
MH  - Rivers/*chemistry
MH  - Solid Phase Microextraction
MH  - X-Ray Diffraction
OTO - NOTNLM
OT  - Metal-organic framework (MOF)
OT  - Milk
OT  - Penicillin
OT  - Polymer monolithic column
OT  - Solid-phase microextraction (SPME)
EDAT- 2015/06/13 06:00
MHDA- 2016/08/09 06:00
CRDT- 2015/06/13 06:00
PHST- 2015/02/20 00:00 [received]
PHST- 2015/05/14 00:00 [revised]
PHST- 2015/05/18 00:00 [accepted]
PHST- 2015/06/13 06:00 [entrez]
PHST- 2015/06/13 06:00 [pubmed]
PHST- 2016/08/09 06:00 [medline]
AID - S0021-9673(15)00753-0 [pii]
AID - 10.1016/j.chroma.2015.05.043 [doi]
PST - ppublish
SO  - J Chromatogr A. 2016 Jan 8;1428:236-45. doi: 10.1016/j.chroma.2015.05.043. Epub 
      2015 May 27.