PMID- 26067141
OWN - NLM
STAT- MEDLINE
DCOM- 20170531
LR  - 20180313
IS  - 1533-4058 (Electronic)
IS  - 1533-4058 (Linking)
VI  - 24
IP  - 6
DP  - 2016 Jul
TI  - Expression of TIA1 and PAX5 in Classical Hodgkin Lymphoma at Initial Diagnosis 
      May Predict Clinical Outcome.
PG  - 383-91
LID - 10.1097/PAI.0000000000000200 [doi]
AB  - Although the expression of T-cell antigens and proteins associated with 
      tumor-infiltrating T-lymphocytes (TILs), regulatory T cells (T-regs), and B-cell 
      development have been evaluated in classical Hodgkin lymphoma (cHL), few studies 
      correlate these proteins' expression patterns with clinical outcome. The purpose 
      of this study was to evaluate proteins expressed in the Reed-Sternberg cells 
      (RSCs) and TILs of cHLs at initial diagnosis to determine their prognostic 
      significance. The expression of 12 proteins in RSCs and TILs from 88 diagnostic 
      cHL biopsies was quantitated and correlated to overall survival (OS) and 
      progression-free survival (PFS). CD2, CD3, CD4, CD5, CD7, CD25, PD1, TIA1, MUM1, 
      and ZAP70 expression in RSCs did not correlate with OS or PFS, nor did programmed 
      death 1 (PD1) expression in TILs. High numbers of TIA1-positive TILs (>/=50%) 
      correlated with OS (P=0.027), but not PFS (P=0.993) in univariate analysis. 
      Expression of CD2, CD3, CD4, CD5, and/or TIA1 (6%) in RSCs was associated with 
      lymphocyte-rich/mixed-cellularity subtype (P=0.032). High International 
      Prognostic Score (IPS; P=0.036), and high stage (P=0.046) were independent 
      predictors of worse PFS in univariate analysis. Low IPS (P=0.003) and nodular 
      sclerosing subtype (P=0.022) were associated with better OS in univariate 
      analysis. Only the IPS predicted OS in multivariate (P=0.009) analysis. High 
      TIA1+ TILs correlated with worse clinical outcomes for cHLs, as did PAX5-RSCs 
      (P=0.024), although only 2/74 cases were shown to be negative for this marker, 
      suggesting that the tumor microenvironment and a transcription factor crucial for 
      B-cell development are critical biological determinants of the disease course.
FAU - Nguyen, TuDung T
AU  - Nguyen TT
AD  - *Department of Pathology and Immunonology, Washington University Medical Center 
      Divisions of daggerBiostatistics double daggerOncology, Washington University School of Medicine, 
      Saint Louis, MO.
FAU - Frater, John L
AU  - Frater JL
FAU - Klein, Jonathan
AU  - Klein J
FAU - Chen, Ling
AU  - Chen L
FAU - Bartlett, Nancy L
AU  - Bartlett NL
FAU - Foyil, Kelley V
AU  - Foyil KV
FAU - Kreisel, Friederike H
AU  - Kreisel FH
LA  - eng
GR  - P30 CA091842/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Appl Immunohistochem Mol Morphol
JT  - Applied immunohistochemistry & molecular morphology : AIMM
JID - 100888796
RN  - 0 (PAX5 Transcription Factor)
RN  - 0 (PAX5 protein, human)
RN  - 0 (Poly(A)-Binding Proteins)
RN  - 0 (T-Cell Intracellular Antigen-1)
RN  - 0 (TIA1 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Hodgkin Disease/diagnosis/*metabolism/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - PAX5 Transcription Factor/*metabolism
MH  - Poly(A)-Binding Proteins/*metabolism
MH  - Prognosis
MH  - T-Cell Intracellular Antigen-1
MH  - Tissue Array Analysis
EDAT- 2015/06/13 06:00
MHDA- 2017/06/01 06:00
CRDT- 2015/06/13 06:00
PHST- 2015/06/13 06:00 [entrez]
PHST- 2015/06/13 06:00 [pubmed]
PHST- 2017/06/01 06:00 [medline]
AID - 10.1097/PAI.0000000000000200 [doi]
PST - ppublish
SO  - Appl Immunohistochem Mol Morphol. 2016 Jul;24(6):383-91. doi: 
      10.1097/PAI.0000000000000200.