PMID- 26067213
OWN - NLM
STAT- MEDLINE
DCOM- 20160310
LR  - 20220330
IS  - 1744-7682 (Electronic)
IS  - 1471-2598 (Linking)
VI  - 15
IP  - 9
DP  - 2015
TI  - Human umbilical cord mesenchymal stem cells: an overview of their potential in 
      cell-based therapy.
PG  - 1293-306
LID - 10.1517/14712598.2015.1051528 [doi]
AB  - INTRODUCTION: Human umbilical cord mesenchymal stem cells (HUC-MSCs) are one of 
      the typical adult stem cells; they have superiorities including low 
      immunogenicity, non-invasive harvest procedure, easy expansion in vitro, and 
      ethical access compared with stem cells from other sources. Therefore, HUC-MSCs 
      are a promising candidate for cell-based therapy. AREAS COVERED: Here we reviewed 
      the development of stem cell-based therapy, the manufacturing and banking process 
      of HUC-MSCs, the emerging clinical studies in the field of cancer, central 
      nervous system diseases, liver diseases and graft-versus-host disease, the 
      potential therapeutic mechanisms, as well as challenges of HUC-MSCs in clinical 
      translation. EXPERT OPINION: HUC-MSCs seem to be an optimal choice for stem 
      cell-based therapy. However, before the cells translate from basic to clinical 
      research, some problems still remain to be solved: i) building regulatory 
      guidelines as well as an efficient and safe manufacturing procedure; ii) 
      establishing donor's genetic testing and long-term closely monitoring system; 
      iii) conducting further clinical trials to determine the optimum and standard 
      dosage, time, route, frequency and many other technical issues of HUC-MSCs 
      transplantation.
FAU - Li, Tan
AU  - Li T
AD  - Drum Tower Hospital, Medical School of Nanjing University, Department of 
      Neurology , 321 Zhongshan Road, Nanjing City, Jiangsu Province 210008 , China +86 
      25 6818 2212 ; +86 25 8310 5208 ; xuyun20042001@aliyun.com ; 
      y.chen860606@gmail.com.
FAU - Xia, Mingxu
AU  - Xia M
FAU - Gao, Yuanyuan
AU  - Gao Y
FAU - Chen, Yanting
AU  - Chen Y
FAU - Xu, Yun
AU  - Xu Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150612
PL  - England
TA  - Expert Opin Biol Ther
JT  - Expert opinion on biological therapy
JID - 101125414
SB  - IM
MH  - Cell- and Tissue-Based Therapy
MH  - Central Nervous System Diseases/therapy
MH  - Graft vs Host Disease/therapy
MH  - Humans
MH  - Liver Diseases/therapy
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*cytology/metabolism
MH  - Neoplasms/therapy
MH  - Umbilical Cord/*cytology
OTO - NOTNLM
OT  - clinical application
OT  - cryopreservation
OT  - human umbilical cord mesenchymal stem cells
OT  - isolation
OT  - paracrine
EDAT- 2015/06/13 06:00
MHDA- 2016/03/11 06:00
CRDT- 2015/06/13 06:00
PHST- 2015/06/13 06:00 [entrez]
PHST- 2015/06/13 06:00 [pubmed]
PHST- 2016/03/11 06:00 [medline]
AID - 10.1517/14712598.2015.1051528 [doi]
PST - ppublish
SO  - Expert Opin Biol Ther. 2015;15(9):1293-306. doi: 10.1517/14712598.2015.1051528. 
      Epub 2015 Jun 12.