PMID- 26068917
OWN - NLM
STAT- MEDLINE
DCOM- 20160310
LR  - 20181217
IS  - 1165-158X (Electronic)
IS  - 0145-5680 (Linking)
VI  - 61
IP  - 3
DP  - 2015 Jun 10
TI  - Vitamin D Deficiency, Obesity and Diabetes.
PG  - 35-8
AB  - Obesity and type 2 diabetes mellitus (T2DM) are main chronic diseases harming 
      human health. Although the association between obesity and T2DM is well 
      established, the molecular mechanism is still unclear. Accumulating evidence 
      suggests vitamin D plays a role in the development of these diseases. Vitamin D 
      is a necessary nutrient for humans. People usually do not pay attention to 
      supplementing vitamin D, since vitamin D can be produced when their skin is 
      exposed to the sunlight. Nevertheless, even in highly sunny regions, vitamin D 
      deficiency exists, suggesting vitamin D deficiency is a global problem. Vitamin D 
      deficiency has previously been considered only to influence bone metabolism. 
      Accumulating evidence counters this opinion. In vivo studies have revealed that 
      vitamin D deficiency reduces insulin secretion capacity of the islet beta cells 
      in pancreas. Moreover, epidemiological studies have demonstrated that vitamin D 
      deficiency is closely related to obesity and increased risk of T2DM. This review 
      introduces the current work on vitamin D, obesity and diabetes.
FAU - Li, Y-X
AU  - Li YX
AD  - Guangxi University College of Animal Science and Technology Nanning China.
FAU - Zhou, L
AU  - Zhou L
AD  - Guangxi University College of Animal Science and Technology Nanning China 
      zhoulei@gxu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150610
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (Insulin)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*etiology/metabolism
MH  - Humans
MH  - Insulin/metabolism
MH  - Insulin Resistance
MH  - Insulin Secretion
MH  - Insulin-Secreting Cells/metabolism
MH  - Obesity/*etiology/metabolism
MH  - Risk Factors
MH  - Vitamin D/*metabolism
MH  - Vitamin D Deficiency/complications/*pathology
EDAT- 2015/06/13 06:00
MHDA- 2016/03/11 06:00
CRDT- 2015/06/13 06:00
PHST- 2015/05/18 00:00 [received]
PHST- 2015/06/08 00:00 [accepted]
PHST- 2015/06/13 06:00 [entrez]
PHST- 2015/06/13 06:00 [pubmed]
PHST- 2016/03/11 06:00 [medline]
PST - epublish
SO  - Cell Mol Biol (Noisy-le-grand). 2015 Jun 10;61(3):35-8.