PMID- 26069076
OWN - NLM
STAT- MEDLINE
DCOM- 20160620
LR  - 20150923
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 123
IP  - 8
DP  - 2015 Sep
TI  - Relevance and clinical significance of serum resistin level in obese T2DM rhesus 
      monkey models.
PG  - 508-13
LID - 10.1055/s-0035-1554653 [doi]
AB  - Resistin is a type of hormone-like adipocytokines, which is secreted specifically 
      by adipocytes. It may be a key factor in the development of type 2 diabetes 
      mellitus (T2DM) from obesity- associated insulin resistance due to results that 
      show that it has a close relationship with insulin resistance in rodents. We 
      utilized the rhesus monkeys as study objects to preliminarily test the 
      association with glucose metabolism and to conduct a correlation analysis for 
      clinical parameters and serum resistin levels in obese rhesus monkey models of 
      T2DM. The results suggested that resistin was significantly increased in T2DM 
      monkeys (P <0.01), and that resistin had a positive correlation respectively with 
      total cholesterol (TC), low-density lipoprotein (LDL-C), fasting plasma glucose 
      (FPG), fasting insulin (FPI) and glycated hemoglobin (HbA1c), Insulin resistance 
      index (HOA-IR), but a negative correlation with islet beta-cell function (HOMA-beta). 
      In the course of glucose metabolism, reverse release change of resistin and 
      insulin in T2DM monkeys occurred, but the phenomenon that was not observed in the 
      control group, these findings indicated that resistin negatively regulated and 
      interfered with carbohydrate metabolism in T2DM monkey models. The character of 
      the releasing change of resistin might be a unique process in T2DM. Therefore, 
      all of the results could provide references for clinical diagnostic criteria for 
      human cases of T2DM, and could have clinical significance for obese T2DM 
      diagnosis and degree of insulin resistance.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Qi, S-D
AU  - Qi SD
AD  - Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union 
      Medical College; Yunnan Key Laboratory of Vaccine Research and Development on 
      Severe Infectious Diseases.
FAU - He, Z-L
AU  - He ZL
AD  - Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union 
      Medical College; Yunnan Key Laboratory of Vaccine Research and Development on 
      Severe Infectious Diseases.
FAU - Chen, Y
AU  - Chen Y
AD  - Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union 
      Medical College; Yunnan Key Laboratory of Vaccine Research and Development on 
      Severe Infectious Diseases.
FAU - Ma, J
AU  - Ma J
AD  - Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union 
      Medical College; Yunnan Key Laboratory of Vaccine Research and Development on 
      Severe Infectious Diseases.
FAU - Yu, W-H
AU  - Yu WH
AD  - Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union 
      Medical College; Yunnan Key Laboratory of Vaccine Research and Development on 
      Severe Infectious Diseases.
FAU - Li, Y-Y
AU  - Li YY
AD  - Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union 
      Medical College; Yunnan Key Laboratory of Vaccine Research and Development on 
      Severe Infectious Diseases.
FAU - Yang, F-M
AU  - Yang FM
AD  - Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union 
      Medical College; Yunnan Key Laboratory of Vaccine Research and Development on 
      Severe Infectious Diseases.
FAU - Wang, J-B
AU  - Wang JB
AD  - Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union 
      Medical College; Yunnan Key Laboratory of Vaccine Research and Development on 
      Severe Infectious Diseases.
FAU - Chen, L-X
AU  - Chen LX
AD  - Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union 
      Medical College; Yunnan Key Laboratory of Vaccine Research and Development on 
      Severe Infectious Diseases.
FAU - Zhao, Y
AU  - Zhao Y
AD  - Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union 
      Medical College; Yunnan Key Laboratory of Vaccine Research and Development on 
      Severe Infectious Diseases.
FAU - Lu, S-Y
AU  - Lu SY
AD  - Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union 
      Medical College; Yunnan Key Laboratory of Vaccine Research and Development on 
      Severe Infectious Diseases.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150611
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (Resistin)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Experimental/*blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Humans
MH  - Macaca mulatta
MH  - Obesity/*blood
MH  - Resistin/*blood
EDAT- 2015/06/13 06:00
MHDA- 2016/06/21 06:00
CRDT- 2015/06/13 06:00
PHST- 2015/06/13 06:00 [entrez]
PHST- 2015/06/13 06:00 [pubmed]
PHST- 2016/06/21 06:00 [medline]
AID - 10.1055/s-0035-1554653 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2015 Sep;123(8):508-13. doi: 
      10.1055/s-0035-1554653. Epub 2015 Jun 11.