PMID- 26069453
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1388-0764 (Print)
IS  - 1388-0764 (Linking)
VI  - 17
IP  - 6
DP  - 2015
TI  - Comparative hazard analysis and toxicological modeling of diverse nanomaterials
      using the embryonic zebrafish (EZ) metric of toxicity.
PG  - 250
AB  - The integration of rapid assays, large datasets, informatics, and modeling can
      overcome current barriers in understanding nanomaterial structure-toxicity
      relationships by providing a weight-of-the-evidence mechanism to generate hazard 
      rankings for nanomaterials. Here, we present the use of a rapid, low-cost assay
      to perform screening-level toxicity evaluations of nanomaterials in vivo.
      Calculated EZ Metric scores, a combined measure of morbidity and mortality in
      developing embryonic zebrafish, were established at realistic exposure levels and
      used to develop a hazard ranking of diverse nanomaterial toxicity. Hazard ranking
      and clustering analysis of 68 diverse nanomaterials revealed distinct patterns of
      toxicity related to both the core composition and outermost surface chemistry of 
      nanomaterials. The resulting clusters guided the development of a surface
      chemistry-based model of gold nanoparticle toxicity. Our findings suggest that
      risk assessments based on the size and core composition of nanomaterials alone
      may be wholly inappropriate, especially when considering complex engineered
      nanomaterials. Research should continue to focus on methodologies for determining
      nanomaterial hazard based on multiple sub-lethal responses following realistic,
      low-dose exposures, thus increasing the availability of quantitative measures of 
      nanomaterial hazard to support the development of nanoparticle structure-activity
      relationships.
FAU - Harper, Bryan
AU  - Harper B
AD  - Oregon State University, 1007 ALS Building, Corvallis, OR 97331 USA.
FAU - Thomas, Dennis
AU  - Thomas D
AD  - Pacific Northwest National Laboratory, Richland, WA USA.
FAU - Chikkagoudar, Satish
AU  - Chikkagoudar S
AD  - Pacific Northwest National Laboratory, Richland, WA USA.
FAU - Baker, Nathan
AU  - Baker N
AD  - Pacific Northwest National Laboratory, Richland, WA USA.
FAU - Tang, Kaizhi
AU  - Tang K
AD  - Intelligent Automation, Inc., Rockville, MD USA.
FAU - Heredia-Langner, Alejandro
AU  - Heredia-Langner A
AD  - Pacific Northwest National Laboratory, Richland, WA USA.
FAU - Lins, Roberto
AU  - Lins R
AD  - CPqAM, Oswaldo Cruz Foundation, FIOCRUZ-PE, Recife, PE 50.740-465 Brazil.
FAU - Harper, Stacey
AU  - Harper S
AD  - Oregon State University, 1007 ALS Building, Corvallis, OR 97331 USA.
LA  - eng
GR  - P30 ES000210/ES/NIEHS NIH HHS/United States
GR  - R01 ES016896/ES/NIEHS NIH HHS/United States
GR  - R01 ES017552/ES/NIEHS NIH HHS/United States
GR  - U01 NS073457/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20150604
PL  - Netherlands
TA  - J Nanopart Res
JT  - Journal of nanoparticle research : an interdisciplinary forum for nanoscale
      science and technology
JID - 101088075
PMC - PMC4454819
OTO - NOTNLM
OT  - Informatics
OT  - Nanoparticle
OT  - Surface chemistry
OT  - Toxicity
OT  - Zebrafish
EDAT- 2015/06/13 06:00
MHDA- 2015/06/13 06:01
CRDT- 2015/06/13 06:00
PHST- 2014/05/30 00:00 [received]
PHST- 2015/05/26 00:00 [accepted]
PHST- 2015/06/13 06:00 [entrez]
PHST- 2015/06/13 06:00 [pubmed]
PHST- 2015/06/13 06:01 [medline]
AID - 10.1007/s11051-015-3051-0 [doi]
AID - 3051 [pii]
PST - ppublish
SO  - J Nanopart Res. 2015;17(6):250. doi: 10.1007/s11051-015-3051-0. Epub 2015 Jun 4.