PMID- 26069779
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150613
LR  - 20200930
IS  - 2048-8505 (Print)
IS  - 2048-8513 (Electronic)
IS  - 2048-8505 (Linking)
VI  - 5
IP  - 3
DP  - 2012 Jun
TI  - Acute antibody-mediated renal allograft rejection associated with HLA-Cw17 
      antibody.
PG  - 254-6
LID - 10.1093/ckj/sfs042 [doi]
AB  - Detection of donor-specific human leukocyte antigen (HLA) antibodies is an 
      important part of diagnosis of antibody-mediated rejection (AMR) in the renal 
      transplant population. Donor-specific antibodies (DSA) against HLA-C, a Class 1 
      major histocompatibility gene product, are not considered to be of major 
      importance in renal transplant rejection. Typing for HLA-C is not a routine part 
      of pre- and post-transplant evaluation. In roughly 10% of biopsy-proven 
      C4d-positive rejections, DSA are not detected by standard testing protocols. In 
      some of these cases, minor HLA and non-HLA antibodies have been implicated. The 
      role of HLA-C antibodies in this patient group is not clear. We present a patient 
      with acute renal graft dysfunction 21 months post-transplant. The allograft 
      biopsy showed features of AMR with diffuse margination of inflammatory cells and 
      diffuse C4d staining in peritubular capillaries. HLA-Cw17 antibody was detected 
      by single-bead antigen Luminex assay, which was further confirmed by a mock flow 
      crossmatch. This case highlights the importance of checking anti-HLA-Cw 
      antibodies in patients with AMR and no detectable DSA using standard methods.
FAU - Suneja, Manish
AU  - Suneja M
AD  - Department of Internal Medicine, Division of Nephrology and Hypertension, 
      University of Iowa Hospital and Clinics, IA, USA.
FAU - Kuppachi, Sarat
AU  - Kuppachi S
AD  - Department of Internal Medicine, Division of Nephrology and Hypertension, 
      University of Iowa Hospital and Clinics, IA, USA.
LA  - eng
PT  - Case Reports
DEP - 20120419
PL  - England
TA  - Clin Kidney J
JT  - Clinical kidney journal
JID - 101579321
PMC - PMC4400515
OTO - NOTNLM
OT  - HLA-Cw17
OT  - antibody-mediated rejection
OT  - crossmatch
OT  - kidney transplant
OT  - single-antigen bead assay
EDAT- 2012/06/01 00:00
MHDA- 2012/06/01 00:01
PMCR- 2012/04/19
CRDT- 2015/06/13 06:00
PHST- 2011/12/20 00:00 [received]
PHST- 2012/03/13 00:00 [accepted]
PHST- 2015/06/13 06:00 [entrez]
PHST- 2012/06/01 00:00 [pubmed]
PHST- 2012/06/01 00:01 [medline]
PHST- 2012/04/19 00:00 [pmc-release]
AID - 10.1093/ckj/sfs042 [doi]
PST - ppublish
SO  - Clin Kidney J. 2012 Jun;5(3):254-6. doi: 10.1093/ckj/sfs042. Epub 2012 Apr 19.