PMID- 26070346
OWN - NLM
STAT- MEDLINE
DCOM- 20160819
LR  - 20230722
IS  - 1868-8500 (Electronic)
IS  - 1868-8497 (Print)
IS  - 1868-8497 (Linking)
VI  - 6
IP  - 5-6
DP  - 2015 Dec
TI  - Thymic and Bronchial Carcinoid Tumors in Multiple Endocrine Neoplasia Type 1: The 
      Mayo Clinic Experience from 1977 to 2013.
PG  - 247-53
LID - 10.1007/s12672-015-0228-z [doi]
AB  - The clinical features of thymic carcinoid (TC) and bronchial carcinoid (BC) 
      tumors as part of multiple endocrine neoplasia type 1 (MEN1) have been rarely 
      described and their importance in clinical practice is debated. The objective of 
      this study was to describe the clinical presentation and outcome of this uncommon 
      manifestation of MEN1 in a tertiary care center setting. We present the clinical 
      features of patients with MEN1 and either TC or BC evaluated at the Mayo Clinic 
      from 1977 to 2013. A total of 348 patients with MEN1 were evaluated and the 
      prevalence of TC was 2.0% (n = 7) and of BC 4.9% (n = 17). The majority of the 
      patients with BC were men (61%) diagnosed on routine screening (77%) and BC was 
      not the confirmed cause of death in any patient. In contrast, TC patients were 
      all men and during follow-up 43% died due to TC complications. We conclude that 
      TC and BC tumors are uncommon, but important components of MEN1. BC were most 
      commonly diagnosed during routine screening and associated with an indolent 
      course. TC were predominantly seen in men and associated with a more aggressive 
      behavior.
FAU - Singh Ospina, Naykky
AU  - Singh Ospina N
AD  - Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of 
      Internal Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN, 55905, 
      USA.
FAU - Thompson, Geoffrey B
AU  - Thompson GB
AD  - Section of Endocrine Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, 
      USA.
FAU - C Nichols, Francis 3rd
AU  - C Nichols F 3rd
AD  - Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic, 
      Rochester, MN, USA.
FAU - Cassivi, Stephen D
AU  - Cassivi SD
AD  - Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic, 
      Rochester, MN, USA.
FAU - Young, William F Jr
AU  - Young WF Jr
AD  - Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of 
      Internal Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN, 55905, 
      USA. wyoung@mayo.edu.
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20150613
PL  - United States
TA  - Horm Cancer
JT  - Hormones & cancer
JID - 101518427
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bronchial Neoplasms/*diagnosis/epidemiology/history/*therapy
MH  - Carcinoid Tumor/*diagnosis/epidemiology/history/*therapy
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Follow-Up Studies
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis/epidemiology/history/*therapy
MH  - Prevalence
MH  - Thymus Neoplasms/*diagnosis/epidemiology/history/*therapy
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC10355915
COIS- The authors declare that they have no conflict of interest.
EDAT- 2015/06/14 06:00
MHDA- 2016/08/20 06:00
PMCR- 2015/06/13
CRDT- 2015/06/14 06:00
PHST- 2015/03/30 00:00 [received]
PHST- 2015/05/29 00:00 [accepted]
PHST- 2015/06/14 06:00 [entrez]
PHST- 2015/06/14 06:00 [pubmed]
PHST- 2016/08/20 06:00 [medline]
PHST- 2015/06/13 00:00 [pmc-release]
AID - 10.1007/s12672-015-0228-z [pii]
AID - 228 [pii]
AID - 10.1007/s12672-015-0228-z [doi]
PST - ppublish
SO  - Horm Cancer. 2015 Dec;6(5-6):247-53. doi: 10.1007/s12672-015-0228-z. Epub 2015 
      Jun 13.