PMID- 26071584
OWN - NLM
STAT- MEDLINE
DCOM- 20150908
LR  - 20180816
IS  - 0172-780X (Print)
IS  - 0172-780X (Linking)
VI  - 36
IP  - 2
DP  - 2015
TI  - Assessment of plasma brain-derived neurotrophic factor (BDNF), activity-dependent 
      neurotrophin protein (ADNP) and vasoactive intestinal peptide (VIP) 
      concentrations in treatment-naive humans with multiple sclerosis.
PG  - 148-52
AB  - OBJECTIVE: Multiple sclerosis (MS) is a chronic disease of the central nervous 
      system (CNS) characterized by coexisting processes of inflammation, 
      demyelination, axonal neurodegeneration and gliosis. Autoimmune processes play a 
      pivotal role in the disease. The immune system may be modulated by neurotrophins 
      and neurotrophin factors. Aim of the study was to assess plasma levels of 
      brain-derived neurotrophic factor (BDNF), activity-dependent neurotrophin protein 
      (ADNP) and vasoactive intestinal peptide (VIP) in treatment-naive humans with 
      newly diagnosed multiple sclerosis. We also elucidated the potential influence of 
      selected inflammatory agents on peripheral concentration of BDNF and ADNP. 
      MATERIAL AND METHODS: The study population comprised of 31 untreated patients 
      with MS and 36 controls from a single hospital centre. Assessment of BDNF and 
      ADNP was performed with use of ELISA methods. VIP was measured with RIA. Selected 
      cytokine levels (IL 6, IL 10, and TNF alpha) were evaluated with ELISA tests. 
      Statistical analyses were performed. RESULTS: We failed to find any significant 
      differences between ADNP, BDNF, VIP, CRP levels and concentration of cytokines 
      between individuals with MS and the controls. No correlation was observed between 
      ADNP, BDNF and VIP as the first parameter and CRP, IL 6, IL 10, TNFalpha levels and 
      the Expanded Disability Status Scale score in MS. CONCLUSIONS: Newly diagnosed, 
      treatment-naive patients with MS have comparable levels of plasma BDNF, ADNP and 
      VIP to those of healthy controls.
FAU - Kochanowski, Jan
AU  - Kochanowski J
AD  - Department of Neurology, Medical University of Warsaw, Bielanski Hospital, 
      Warsaw,, Poland.
FAU - Uchman, Dorota
AU  - Uchman D
AD  - Department of Neurology, Medical University of Warsaw, Bielanski Hospital, 
      Warsaw,, Poland.
FAU - Litwiniuk, Anna
AU  - Litwiniuk A
AD  - Department of Neuroendocrinology, Centre of Postgraduate Medical Education, 
      Warsaw, Poland.
FAU - Kalisz, Malgorzata
AU  - Kalisz M
AD  - Department of Neuroendocrinology, Centre of Postgraduate Medical Education, 
      Warsaw, Poland.
FAU - Wolinska-Witort, Ewa
AU  - Wolinska-Witort E
AD  - Department of Neuroendocrinology, Centre of Postgraduate Medical Education, 
      Warsaw, Poland.
FAU - Martynska, Lidia
AU  - Martynska L
AD  - Department of Neuroendocrinology, Centre of Postgraduate Medical Education, 
      Warsaw, Poland.
FAU - Baranowska, Boguslawa
AU  - Baranowska B
AD  - Department of Neurology, Medical University of Warsaw, Bielanski Hospital, 
      Warsaw,, Poland.
FAU - Bik, Wojciech
AU  - Bik W
AD  - Department of Neuroendocrinology, Centre of Postgraduate Medical Education, 
      Warsaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Neuro Endocrinol Lett
JT  - Neuro endocrinology letters
JID - 8008373
RN  - 0 (ADNP protein, human)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Female
MH  - Homeodomain Proteins/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*blood
MH  - Nerve Tissue Proteins/*blood
MH  - Vasoactive Intestinal Peptide/*blood
MH  - Young Adult
EDAT- 2015/06/14 06:00
MHDA- 2015/09/09 06:00
CRDT- 2015/06/14 06:00
PHST- 2015/04/26 00:00 [received]
PHST- 2015/05/03 00:00 [accepted]
PHST- 2015/06/14 06:00 [entrez]
PHST- 2015/06/14 06:00 [pubmed]
PHST- 2015/09/09 06:00 [medline]
AID - NEL360215A03 [pii]
PST - ppublish
SO  - Neuro Endocrinol Lett. 2015;36(2):148-52.