PMID- 2607382
OWN - NLM
STAT- MEDLINE
DCOM- 19900216
LR  - 20190919
IS  - 0096-1736 (Print)
IS  - 0096-1736 (Linking)
VI  - 31
IP  - 10
DP  - 1989 Oct
TI  - Allergy to laboratory animals: a prospective and cross-sectional study.
PG  - 842-6
AB  - Allergies among animal handlers to their subjects is a problem of high prevalence 
      and relatively low morbidity but with often serious career implications. This 
      study sought to determine whether historical factors, such as general allergic 
      symptoms and atopic indicators, could be used to predict which animal handlers 
      would be affected with allergies to laboratory animals (ALA). In a prospective 
      study, 169 laboratory workers with animal exposure were surveyed by questionnaire 
      for these factors in 1985 and again 2 years later. The presence of three general 
      allergic symptoms (relative risk = 4.29) and three historical atopic indicators 
      (relative risk = 2.50) were moderately predictive of the new onset of ALA. This 
      suggests that those animals handlers with allergic histories are at greater risk 
      of developing ALA, although this is a relatively nonspecific marker. In a 
      concurrent prevalence study, the measurement of airborne rat urinary protein was 
      significantly associated with the presence of ALA (prevalence ratio = 1.75). The 
      measurement of airborne allergens could be helpful in monitoring the 
      effectiveness of air handling equipment with the ultimate goal of reducing the 
      incidence of ALA.
FAU - Kibby, T
AU  - Kibby T
AD  - Duke University Occupational Health Service, Duke University Medical Center, 
      Durham, NC 27710.
FAU - Powell, G
AU  - Powell G
FAU - Cromer, J
AU  - Cromer J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Occup Med
JT  - Journal of occupational medicine. : official publication of the Industrial 
      Medical Association
JID - 7502807
SB  - IM
MH  - Animals
MH  - *Animals, Laboratory
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Hypersensitivity/*etiology
MH  - Occupational Diseases/etiology/immunology
MH  - Prospective Studies
MH  - Rats
EDAT- 1989/10/01 00:00
MHDA- 1989/10/01 00:01
CRDT- 1989/10/01 00:00
PHST- 1989/10/01 00:00 [pubmed]
PHST- 1989/10/01 00:01 [medline]
PHST- 1989/10/01 00:00 [entrez]
AID - 10.1097/00043764-198910000-00010 [doi]
PST - ppublish
SO  - J Occup Med. 1989 Oct;31(10):842-6. doi: 10.1097/00043764-198910000-00010.