PMID- 26073985
OWN - NLM
STAT- MEDLINE
DCOM- 20151125
LR  - 20170914
IS  - 1557-8445 (Electronic)
IS  - 0065-2776 (Linking)
VI  - 127
DP  - 2015
TI  - IgE and Mast Cells: The Endogenous Adjuvant.
PG  - 203-56
LID - S0065-2776(15)00028-0 [pii]
LID - 10.1016/bs.ai.2015.03.001 [doi]
AB  - Mast cells and immunoglobulin E (IgE) are most familiar as the effectors of type 
      I hypersensitivity reactions including anaphylaxis. It is becoming clear however 
      that this pair has important immunomodulatory effects on innate and adaptive 
      cells of the immune system. In this purview, they act as endogenous adjuvants to 
      ignite evolving immune responses, promote the transition of allergic disease into 
      chronic illness, and disrupt the development of active mechanisms of tolerance to 
      ingested foods. Suppression of IgE-mediated mast cell activation can be exerted 
      by molecules targeting IgE, FcvarepsilonRI, or signaling kinases including Syk, or by IgG 
      antibodies acting via inhibitory Fcgamma receptors. Recent reports indicate that such 
      interventions have promise in the development of strategies to treat allergic 
      disease.
CI  - (c) 2015 Elsevier Inc. All rights reserved.
FAU - Oettgen, Hans C
AU  - Oettgen HC
AD  - Division of Immunology, Boston Children's Hospital, Boston, Massachusetts, USA; 
      Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA. 
      Electronic address: hans.oettgen@childrens.harvard.edu.
FAU - Burton, Oliver T
AU  - Burton OT
AD  - Division of Immunology, Boston Children's Hospital, Boston, Massachusetts, USA; 
      Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
LA  - eng
GR  - K01 DK106303/DK/NIDDK NIH HHS/United States
GR  - 5T32AI007512-28/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20150325
PL  - United States
TA  - Adv Immunol
JT  - Advances in immunology
JID - 0370425
RN  - 0 (Receptors, IgE)
RN  - 0 (Receptors, IgG)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Food Hypersensitivity/immunology
MH  - Humans
MH  - Hypersensitivity/immunology
MH  - Immunoglobulin E/*immunology
MH  - Mast Cells/*immunology
MH  - Receptors, IgE/immunology
MH  - Receptors, IgG/immunology
OTO - NOTNLM
OT  - FcvarepsilonRI
OT  - FcgammaRIIb
OT  - Food allergy
OT  - IgE
OT  - Immune modulation
OT  - Mast cell
OT  - OIT
OT  - Oral tolerance
OT  - Th2
OT  - Treg
EDAT- 2015/06/16 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/06/16 06:00
PHST- 2015/06/16 06:00 [entrez]
PHST- 2015/06/16 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0065-2776(15)00028-0 [pii]
AID - 10.1016/bs.ai.2015.03.001 [doi]
PST - ppublish
SO  - Adv Immunol. 2015;127:203-56. doi: 10.1016/bs.ai.2015.03.001. Epub 2015 Mar 25.