PMID- 26074330
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 29
IP  - 9
DP  - 2015 Sep
TI  - Schisandrin C Ameliorates Learning and Memory Deficits by Abeta(1-42) -induced 
      Oxidative Stress and Neurotoxicity in Mice.
PG  - 1373-1380
LID - 10.1002/ptr.5390 [doi]
AB  - Schisandrin C (SCH-C) is a main and typical antioxidative lignan isolated from 
      the fruits of Schisandra chinensis (Trucz.) Baill (a widely used traditional 
      Chinese medicine). The present study aimed to characterize the effect of SCH-C on 
      memory impairment and further research on pathological changes in Abeta(1-42) 
      -induced Alzheimer's disease mice. Mice were administration with SCH-C daily for 
      5 days in the lateral cerebral ventricles using sterotaxically implanted cannula. 
      Cognitive functions were assessed by Y-maze test, active avoidance test and 
      Morris water maze test in all groups, and the level of Abeta(1-42) and neuronal 
      injury induced by Abeta(1-42) were reversed remarkably following SCH-C treatment 
      compared with sham group; meanwhile the impairment of short-term or working 
      memory was dramatically improved. In addition, SCH-C significantly inhibited 
      total cholinesterase (ChEtotal), and increased superoxide dismutase (SOD) and 
      glutathione peroxidase (GSH-px) activity glutathione (GSH) levels in the 
      hippocampus and cerebral cortex. It can be speculated that SCH-C offers 
      protection against Abeta(1-42) -induced dysfunction in learning and memory by 
      inhibiting ChEtotal and its antioxidant action. Copyright (c) 2015 John Wiley & 
      Sons, Ltd.
CI  - Copyright (c) 2015 John Wiley & Sons, Ltd.
FAU - Mao, Xin
AU  - Mao X
AD  - Shenyang Key Laboratory of Active Components of Chinese Medicine Screening and 
      Evaluation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical 
      University, Shenyang, China.
FAU - Liao, Zhengzheng
AU  - Liao Z
AD  - Shenyang Key Laboratory of Active Components of Chinese Medicine Screening and 
      Evaluation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical 
      University, Shenyang, China.
FAU - Guo, Lin
AU  - Guo L
AD  - Shenyang Key Laboratory of Active Components of Chinese Medicine Screening and 
      Evaluation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical 
      University, Shenyang, China.
FAU - Xu, Xuan
AU  - Xu X
AD  - Shenyang Key Laboratory of Active Components of Chinese Medicine Screening and 
      Evaluation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical 
      University, Shenyang, China.
FAU - Wu, Bo
AU  - Wu B
AD  - Shenyang Key Laboratory of Active Components of Chinese Medicine Screening and 
      Evaluation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical 
      University, Shenyang, China.
FAU - Xu, Mengjie
AU  - Xu M
AD  - Shenyang Key Laboratory of Active Components of Chinese Medicine Screening and 
      Evaluation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical 
      University, Shenyang, China.
FAU - Zhao, Xu
AU  - Zhao X
AD  - Shenyang Key Laboratory of Active Components of Chinese Medicine Screening and 
      Evaluation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical 
      University, Shenyang, China.
FAU - Bi, Kaishun
AU  - Bi K
AD  - The Engineering Laboratory of National and Local Union of Quality Control for 
      Traditional Chinese Medicine, School of Pharmacy, Shenyang Pharmaceutical 
      University, Shenyang, China.
FAU - Jia, Ying
AU  - Jia Y
AD  - Shenyang Key Laboratory of Active Components of Chinese Medicine Screening and 
      Evaluation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical 
      University, Shenyang, China.
LA  - eng
PT  - Journal Article
DEP - 20150614
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Abeta1-42
OT  - antioxidant
OT  - intracerebroventricular injection
OT  - neuroprotective effect
OT  - schisandrin C
EDAT- 2015/06/16 06:00
MHDA- 2015/06/16 06:01
CRDT- 2015/06/16 06:00
PHST- 2014/07/16 00:00 [received]
PHST- 2015/04/29 00:00 [revised]
PHST- 2015/05/16 00:00 [accepted]
PHST- 2015/06/16 06:00 [pubmed]
PHST- 2015/06/16 06:01 [medline]
PHST- 2015/06/16 06:00 [entrez]
AID - 10.1002/ptr.5390 [doi]
PST - ppublish
SO  - Phytother Res. 2015 Sep;29(9):1373-1380. doi: 10.1002/ptr.5390. Epub 2015 Jun 14.