PMID- 26074695
OWN - NLM
STAT- MEDLINE
DCOM- 20160318
LR  - 20211203
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 21
IP  - 21
DP  - 2015 Jun 7
TI  - Effect of resveratrol on Treg/Th17 signaling and ulcerative colitis treatment in 
      mice.
PG  - 6572-81
LID - 10.3748/wjg.v21.i21.6572 [doi]
AB  - AIM: To determine the therapeutic efficacy of resveratrol on ulcerative colitis 
      (UC) and its underlying mechanisms. METHODS: The mouse UC model was developed 
      using 5% dextran sulfate sodium. Mice were randomly divided into four groups: 
      normal control, UC model group, resveratrol low-dose group (RLD; 50 mg/kg per 
      day), and resveratrol high-dose group (RHD; 100 mg/kg per day). RESULTS: The 
      results showed that RLD regulates Treg/Th17 balance mainly through reducing the 
      number of Th17 cells, whereas RHD regulates Treg/Th17 balance through both 
      downregulating the number of Th17 cells and upregulating the number of Treg 
      cells. Resveratrol can also regulate the level of plasma and intestinal mucosal 
      cytokines including interleukin (IL)-10, transforming growth factor-beta1, IL-6, and 
      IL-17. The expressions of hypoxia inducible factor (HIF)-1alpha, mammalian target of 
      rapamycin (mTOR), and signal transducer and activator of transcription 3 were 
      significantly decreased in the intestinal tissues of mice treated with 
      resveratrol. CONCLUSION: The therapeutic efficacy of resveratrol in UC is dose 
      dependent and closely associated with the regulation of Treg/Th17 balance and the 
      HIF-1alpha/mTOR signaling pathway.
FAU - Yao, Jun
AU  - Yao J
AD  - Jun Yao, Cheng Wei, Ru Zhang, Ying-Xue Li, Li-sheng Wang, Department of 
      Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal 
      People's Hospital, Shenzhen 518020, Guangdong Province, China.
FAU - Wei, Cheng
AU  - Wei C
AD  - Jun Yao, Cheng Wei, Ru Zhang, Ying-Xue Li, Li-sheng Wang, Department of 
      Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal 
      People's Hospital, Shenzhen 518020, Guangdong Province, China.
FAU - Wang, Jian-Yao
AU  - Wang JY
AD  - Jun Yao, Cheng Wei, Ru Zhang, Ying-Xue Li, Li-sheng Wang, Department of 
      Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal 
      People's Hospital, Shenzhen 518020, Guangdong Province, China.
FAU - Zhang, Ru
AU  - Zhang R
AD  - Jun Yao, Cheng Wei, Ru Zhang, Ying-Xue Li, Li-sheng Wang, Department of 
      Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal 
      People's Hospital, Shenzhen 518020, Guangdong Province, China.
FAU - Li, Ying-Xue
AU  - Li YX
AD  - Jun Yao, Cheng Wei, Ru Zhang, Ying-Xue Li, Li-sheng Wang, Department of 
      Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal 
      People's Hospital, Shenzhen 518020, Guangdong Province, China.
FAU - Wang, Li-Sheng
AU  - Wang LS
AD  - Jun Yao, Cheng Wei, Ru Zhang, Ying-Xue Li, Li-sheng Wang, Department of 
      Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal 
      People's Hospital, Shenzhen 518020, Guangdong Province, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Cytokines)
RN  - 0 (Hif1a protein, mouse)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Inflammation Mediators)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (Stat3 protein, mouse)
RN  - 0 (Stilbenes)
RN  - 9042-14-2 (Dextran Sulfate)
RN  - EC 2.7.1.1 (mTOR protein, mouse)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Colitis/chemically induced/immunology/metabolism/pathology/*prevention & control
MH  - Colon/*drug effects/immunology/metabolism/pathology
MH  - Cytokines/metabolism
MH  - Dextran Sulfate
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
MH  - Inflammation Mediators/metabolism
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Resveratrol
MH  - STAT3 Transcription Factor/metabolism
MH  - Signal Transduction/*drug effects
MH  - Spleen/drug effects/immunology/metabolism
MH  - Stilbenes/*pharmacology
MH  - T-Lymphocytes, Regulatory/*drug effects/immunology/metabolism
MH  - TOR Serine-Threonine Kinases/metabolism
MH  - Th17 Cells/*drug effects/immunology/metabolism
MH  - Time Factors
PMC - PMC4458767
OTO - NOTNLM
OT  - Hypoxia inducible factor-alpha
OT  - Mammalian target of rapamycin
OT  - Resveratrol
OT  - Th17 cells
OT  - Treg cells
OT  - Ulcerative colitis
EDAT- 2015/06/16 06:00
MHDA- 2016/03/19 06:00
PMCR- 2015/06/07
CRDT- 2015/06/16 06:00
PHST- 2014/11/26 00:00 [received]
PHST- 2015/01/23 00:00 [revised]
PHST- 2015/03/12 00:00 [accepted]
PHST- 2015/06/16 06:00 [entrez]
PHST- 2015/06/16 06:00 [pubmed]
PHST- 2016/03/19 06:00 [medline]
PHST- 2015/06/07 00:00 [pmc-release]
AID - 10.3748/wjg.v21.i21.6572 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2015 Jun 7;21(21):6572-81. doi: 10.3748/wjg.v21.i21.6572.