PMID- 26074741
OWN - NLM
STAT- MEDLINE
DCOM- 20160111
LR  - 20181113
IS  - 1570-159X (Print)
IS  - 1875-6190 (Electronic)
IS  - 1570-159X (Linking)
VI  - 13
IP  - 1
DP  - 2015 Jan
TI  - Cathinone neurotoxicity ("The "3Ms").
PG  - 21-5
LID - 10.2174/1570159X13666141210225009 [doi]
AB  - Synthetic cathinones are designer drugs of the phenethylamine class, structurally 
      and pharmacologically similar to amphetamine, 3,4-methylenedioxymethamphetamine 
      (MDMA), cathinone and other related substances. New analogues, legal at least, 
      until formally banned (a time consuming process), are introduced almost daily The 
      United Nations estimates nearly 250 new drug analogues are produced per year. 
      Various combinations of these drugs are sold under the name of "bath salts". They 
      can be ingested by any route and some appear capable of causing great harm, 
      mostly behavioral. One drug in particular, MDVP, appears to frequently cause 
      symptoms indistinguishable from the classic findings in Excited Delirium Syndrome 
      (ExDS). Little is known about the pathology or clinical toxicology of these drugs 
      but their molecular mechanism of action seems to be identical with that of 
      cocaine. This mini-review examines what little is known on the subject and 
      explains the suspected mechanisms of excited delirium syndrome.
FAU - Karch, Steven B
AU  - Karch SB
AD  - PO Box 5139, Berkeley, CA 94705-0139.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Neuropharmacol
JT  - Current neuropharmacology
JID - 101157239
RN  - 0 (Alkaloids)
RN  - 0 (Designer Drugs)
RN  - 540EI4406J (cathinone)
SB  - IM
MH  - Alkaloids/*adverse effects/toxicity
MH  - Delirium/chemically induced/psychology
MH  - Designer Drugs/*adverse effects/toxicity
MH  - Humans
MH  - Neurotoxicity Syndromes/*physiopathology/*psychology
PMC - PMC4462040
OTO - NOTNLM
OT  - MDMA
OT  - MDVP
OT  - cathinones
OT  - methedrone
OT  - methelone
OT  - "Bath salts"
EDAT- 2015/06/16 06:00
MHDA- 2015/06/16 06:01
PMCR- 2015/07/01
CRDT- 2015/06/16 06:00
PHST- 2014/05/06 00:00 [received]
PHST- 2014/06/21 00:00 [revised]
PHST- 2014/10/25 00:00 [accepted]
PHST- 2015/06/16 06:00 [entrez]
PHST- 2015/06/16 06:00 [pubmed]
PHST- 2015/06/16 06:01 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - CN-13-21 [pii]
AID - 10.2174/1570159X13666141210225009 [doi]
PST - ppublish
SO  - Curr Neuropharmacol. 2015 Jan;13(1):21-5. doi: 10.2174/1570159X13666141210225009.