PMID- 26074866
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150615
LR  - 20220330
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 6
DP  - 2015
TI  - Blood Biomarkers in Moderate-To-Severe Traumatic Brain Injury: Potential Utility 
      of a Multi-Marker Approach in Characterizing Outcome.
PG  - 110
LID - 10.3389/fneur.2015.00110 [doi]
LID - 110
AB  - BACKGROUND: Blood biomarkers are valuable tools for elucidating complex cellular 
      and molecular mechanisms underlying traumatic brain injury (TBI). Profiling 
      distinct classes of biomarkers could aid in the identification and 
      characterization of initial injury and secondary pathological processes. This 
      study characterized the prognostic performance of a recently developed 
      multi-marker panel of circulating biomarkers that reflect specific pathogenic 
      mechanisms including neuroinflammation, oxidative damage, and neuroregeneration, 
      in moderate-to-severe TBI patients. MATERIALS AND METHODS: Peripheral blood was 
      drawn from 85 isolated TBI patients (n = 60 severe, n = 25 moderate) at hospital 
      admission, 6-, 12-, and 24-h post-injury. Mortality and neurological outcome were 
      assessed using the extended Glasgow Outcome Scale. A multiplex platform was 
      designed on MULTI-SPOT((R)) plates to simultaneously analyze human plasma levels of 
      s100 calcium binding protein beta (s100B), glial fibrillary acidic protein 
      (GFAP), neuron specific enolase (NSE), brain-derived neurotrophic factor (BDNF), 
      monocyte chemoattractant protein (MCP)-1, intercellular adhesion molecule 
      (ICAM)-5, and peroxiredoxin (PRDX)-6. Multivariable logistic regression and area 
      under the receiver-operating characteristic curve (AUC) were used to evaluate 
      both individual and combined predictive abilities of these markers for 6-month 
      neurological outcome and mortality after TBI. RESULTS: Unfavorable neurological 
      outcome was associated with elevations in s100B, GFAP, and MCP-1. Mortality was 
      related to differences in six of the seven markers analyzed. Combined admission 
      concentrations of s100B, GFAP, and MCP-1 were able to discriminate favorable 
      versus unfavorable outcome (AUC = 0.83), and survival versus death (AUC = 0.87), 
      although not significantly better than s100B alone (AUC = 0.82 and 0.86, 
      respectively). CONCLUSION: The multi-marker panel of TBI-related biomarkers 
      performed well in discriminating unfavorable and favorable outcomes in the acute 
      period after moderate-to-severe TBI. However, the combination of these biomarkers 
      did not outperform s100B alone.
FAU - Di Battista, Alex P
AU  - Di Battista AP
AD  - Faculty of Medicine, Institute of Medical Science, University of Toronto , 
      Toronto, ON , Canada ; Defence Research and Development Canada, Toronto Research 
      Centre , Toronto, ON , Canada ; Keenan Research Centre, Li Ka Shing Knowledge 
      Institute, St. Michael's Hospital , Toronto, ON , Canada.
FAU - Buonora, John E
AU  - Buonora JE
AD  - Department of Anatomy, Physiology and Genetics, Uniformed Services University of 
      the Health Sciences , Bethesda, MD , USA ; US Army Graduate Program in Anesthesia 
      Nursing , Fort Sam Houston, TX , USA.
FAU - Rhind, Shawn G
AU  - Rhind SG
AD  - Defence Research and Development Canada, Toronto Research Centre , Toronto, ON , 
      Canada ; Faculty of Kinesiology and Physical Education, David L. MacIntosh Sport 
      Medicine Clinic, University of Toronto , Toronto, ON , Canada.
FAU - Hutchison, Michael G
AU  - Hutchison MG
AD  - Faculty of Kinesiology and Physical Education, David L. MacIntosh Sport Medicine 
      Clinic, University of Toronto , Toronto, ON , Canada.
FAU - Baker, Andrew J
AU  - Baker AJ
AD  - Faculty of Medicine, Institute of Medical Science, University of Toronto , 
      Toronto, ON , Canada ; Keenan Research Centre, Li Ka Shing Knowledge Institute, 
      St. Michael's Hospital , Toronto, ON , Canada ; Department of Anesthesia, 
      University of Toronto , Toronto, ON , Canada ; Department of Surgery and Critical 
      Care Medicine, University of Toronto , Toronto, ON , Canada.
FAU - Rizoli, Sandro B
AU  - Rizoli SB
AD  - Faculty of Medicine, Institute of Medical Science, University of Toronto , 
      Toronto, ON , Canada ; Keenan Research Centre, Li Ka Shing Knowledge Institute, 
      St. Michael's Hospital , Toronto, ON , Canada ; Department of Anesthesia, 
      University of Toronto , Toronto, ON , Canada ; Department of Surgery and Critical 
      Care Medicine, University of Toronto , Toronto, ON , Canada.
FAU - Diaz-Arrastia, Ramon
AU  - Diaz-Arrastia R
AD  - Center for Neuroscience and Regenerative Medicine, Uniformed Services University 
      of the Health Sciences , Bethesda, MD , USA.
FAU - Mueller, Gregory P
AU  - Mueller GP
AD  - Department of Anatomy, Physiology and Genetics, Uniformed Services University of 
      the Health Sciences , Bethesda, MD , USA.
LA  - eng
PT  - Journal Article
DEP - 20150526
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC4443732
OTO - NOTNLM
OT  - BDNF
OT  - GFAP
OT  - ICAM-5
OT  - MCP-1
OT  - NSE
OT  - PRDX-6
OT  - s100B
EDAT- 2015/06/16 06:00
MHDA- 2015/06/16 06:01
PMCR- 2015/05/26
CRDT- 2015/06/16 06:00
PHST- 2015/03/24 00:00 [received]
PHST- 2015/05/04 00:00 [accepted]
PHST- 2015/06/16 06:00 [entrez]
PHST- 2015/06/16 06:00 [pubmed]
PHST- 2015/06/16 06:01 [medline]
PHST- 2015/05/26 00:00 [pmc-release]
AID - 10.3389/fneur.2015.00110 [doi]
PST - epublish
SO  - Front Neurol. 2015 May 26;6:110. doi: 10.3389/fneur.2015.00110. eCollection 2015.