PMID- 26075103
OWN - NLM
STAT- MEDLINE
DCOM- 20160308
LR  - 20181202
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2015
DP  - 2015
TI  - Preclinical Evidences for an Antimanic Effect of Carvedilol.
PG  - 692541
LID - 10.1155/2015/692541 [doi]
LID - 692541
AB  - Oxidative imbalance, alterations in brain-derived neurotrophic factor (BDNF), and 
      mitochondrial dysfunction are implicated in bipolar disorder (BD) pathophysiology 
      and comorbidities, for example, cardiovascular conditions. Carvedilol (CVD), a 
      nonselective beta-blocker widely used for the treatment of hypertension, presents 
      antioxidant and mitochondrial stabilizing properties. Thus, we hypothesized that 
      CVD would prevent and/or reverse mania-like behavioral and neurochemical 
      alterations induced by lisdexamfetamine dimesylate (LDX). To do this, male Wistar 
      rats were submitted to two different protocols, namely, prevention and reversal. 
      In the prevention treatment the rats received daily oral administration (mg/kg) 
      of CVD (2.5, 5 or 7.5), saline, valproate (VAL200), or the combination of CVD5 + 
      VAL100 for 7 days. From the 8th to 14th day LDX was added. In the reversal 
      protocol LDX was administered for 7 days with the drugs being added from the 8th 
      to 14th day of treatment. Two hours after the last administration the behavioral 
      (open field and social interaction) and neurochemical (reduced glutathione, lipid 
      peroxidation, and BDNF) determinations were performed. The results showed that 
      CVD prevented and reversed the behavioral and neurochemical alterations induced 
      by LDX. The administration of CVD5 + VAL100 potentiated the effect of VAL200 
      alone. Taken together these results demonstrate a possible antimanic effect of 
      CVD in this preclinical model.
FAU - de Souza, Greicy Coelho
AU  - de Souza GC
AD  - Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty 
      of Medicine, Federal University of Ceara, Rua Coronel Nunes de Melo 1127, 
      60431-270 Fortaleza, CE, Brazil.
FAU - Gomes, Julia Ariana de S
AU  - Gomes JA
AD  - Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty 
      of Medicine, Federal University of Ceara, Rua Coronel Nunes de Melo 1127, 
      60431-270 Fortaleza, CE, Brazil.
FAU - de Gois Queiroz, Ana Isabelle
AU  - de Gois Queiroz AI
AD  - Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty 
      of Medicine, Federal University of Ceara, Rua Coronel Nunes de Melo 1127, 
      60431-270 Fortaleza, CE, Brazil.
FAU - de Araujo, Maira Morais
AU  - de Araujo MM
AD  - Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty 
      of Medicine, Federal University of Ceara, Rua Coronel Nunes de Melo 1127, 
      60431-270 Fortaleza, CE, Brazil.
FAU - Cavalcante, Ligia Menezes
AU  - Cavalcante LM
AD  - Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty 
      of Medicine, Federal University of Ceara, Rua Coronel Nunes de Melo 1127, 
      60431-270 Fortaleza, CE, Brazil.
FAU - Machado, Michel de Jesus Souza
AU  - Machado Mde J
AD  - Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty 
      of Medicine, Federal University of Ceara, Rua Coronel Nunes de Melo 1127, 
      60431-270 Fortaleza, CE, Brazil.
FAU - Monte, Aline Santos
AU  - Monte AS
AD  - Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty 
      of Medicine, Federal University of Ceara, Rua Coronel Nunes de Melo 1127, 
      60431-270 Fortaleza, CE, Brazil.
FAU - de Lucena, David Freitas
AU  - de Lucena DF
AD  - Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty 
      of Medicine, Federal University of Ceara, Rua Coronel Nunes de Melo 1127, 
      60431-270 Fortaleza, CE, Brazil.
FAU - Quevedo, Joao
AU  - Quevedo J
AD  - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      88806-000 Criciuma, SC, Brazil ; Center for Experimental Models in Psychiatry, 
      Department of Psychiatry and Behavioral Sciences, The University of Texas Medical 
      School at Houston, Houston, TX 77030, USA.
FAU - Carvalho, Andre Ferrer
AU  - Carvalho AF
AD  - Psychiatry Research Group, Faculty of Medicine, Federal University of Ceara, 
      60430-160 Fortaleza, CE, Brazil.
FAU - Macedo, Danielle
AU  - Macedo D
AD  - Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty 
      of Medicine, Federal University of Ceara, Rua Coronel Nunes de Melo 1127, 
      60431-270 Fortaleza, CE, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150514
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Antimanic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Propanolamines)
RN  - 0K47UL67F2 (Carvedilol)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 614OI1Z5WI (Valproic Acid)
RN  - GAN16C9B8O (Glutathione)
RN  - SJT761GEGS (Lisdexamfetamine Dimesylate)
SB  - IM
MH  - Adrenergic beta-Antagonists/administration & dosage/therapeutic use
MH  - Animals
MH  - Antimanic Agents/*administration & dosage/therapeutic use
MH  - Bipolar Disorder/chemically induced/drug therapy/*metabolism
MH  - Brain/*drug effects/*metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Carbazoles/*administration & dosage/therapeutic use
MH  - Carvedilol
MH  - Glutathione/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Lipid Peroxidation/drug effects
MH  - Lisdexamfetamine Dimesylate
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Motor Activity/drug effects
MH  - Propanolamines/*administration & dosage/therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Social Isolation
MH  - Valproic Acid/administration & dosage/therapeutic use
PMC - PMC4446493
EDAT- 2015/06/16 06:00
MHDA- 2016/03/10 06:00
PMCR- 2015/05/14
CRDT- 2015/06/16 06:00
PHST- 2014/08/29 00:00 [received]
PHST- 2014/11/11 00:00 [revised]
PHST- 2014/11/17 00:00 [accepted]
PHST- 2015/06/16 06:00 [entrez]
PHST- 2015/06/16 06:00 [pubmed]
PHST- 2016/03/10 06:00 [medline]
PHST- 2015/05/14 00:00 [pmc-release]
AID - 10.1155/2015/692541 [doi]
PST - ppublish
SO  - Neural Plast. 2015;2015:692541. doi: 10.1155/2015/692541. Epub 2015 May 14.