PMID- 26076394
OWN - NLM
STAT- MEDLINE
DCOM- 20160510
LR  - 20220321
IS  - 1532-432X (Electronic)
IS  - 0363-0269 (Linking)
VI  - 39
IP  - 4
DP  - 2015
TI  - Red Cell Indices and Formulas Used in Differentiation of beta-Thalassemia Trait from 
      Iron Deficiency in Thai Adults.
PG  - 235-9
LID - 10.3109/03630269.2015.1048352 [doi]
AB  - beta-Thalassemia (beta-thal) and iron deficiency cause most microcytic anemias. Red 
      cell indices and formulas have been established as simple, fast, and inexpensive 
      in discrimination between these two hematological disorders in school children. 
      However, whether these formulas could be applied to diagnose beta-thal trait and 
      iron deficiency in adult Thai subjects is unclear. The aim of this study was to 
      examine the diagnostic accuracy of five red cell indices [red blood cell (RBC) 
      counts, mean corpuscular volume (MCV), mean corpuscular hemoglobin (Hb) (MCH), 
      mean corpuscular Hb concentration (MCHC), and red cell distribution width (RDW)] 
      and nine formulas (RDW/RBC, RDW Index, Sirdah, Green and King, Mentzer, England 
      and Fraser, Ehsani, Srivastava and Shine and Lal). Their sensitivity, 
      specificity, positive predictive value (PPV), and negative predictive values 
      (NPV), efficiency, and Youden's Index were analyzed in 102 beta-thal trait and 64 
      iron deficiency adult Thai subjects. The RDW/RBC formula proved to be the most 
      reliable index as they had 100.0% specificity and PPV and the highest efficiency 
      (94.58%) and Youden's Index (91.18%), as well as high sensitivity (91.18%) and 
      NPV (87.67%). Therefore, this formula could be used in initial discrimination of 
      beta-thal trait from iron deficiency in adult Thai subjects.
FAU - Plengsuree, Soontharee
AU  - Plengsuree S
AD  - Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang 
      Mai University , Chiang Mai , Thailand.
FAU - Punyamung, Manoo
AU  - Punyamung M
FAU - Yanola, Jintana
AU  - Yanola J
FAU - Nanta, Siriporn
AU  - Nanta S
FAU - Jaiping, Kanokwan
AU  - Jaiping K
FAU - Maneewong, Kritsanee
AU  - Maneewong K
FAU - Wongwiwatthananukit, Sanchai
AU  - Wongwiwatthananukit S
FAU - Pornprasert, Sakorn
AU  - Pornprasert S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150615
PL  - England
TA  - Hemoglobin
JT  - Hemoglobin
JID - 7705865
RN  - 0 (Biomarkers)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anemia, Iron-Deficiency/*blood/*diagnosis
MH  - Biomarkers/blood
MH  - Diagnosis, Differential
MH  - *Erythrocyte Indices
MH  - Female
MH  - Humans
MH  - Iron/blood
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Thailand
MH  - Young Adult
MH  - beta-Thalassemia/*blood/*diagnosis
OTO - NOTNLM
OT  - Thai adults
OT  - formulas
OT  - iron deficiency
OT  - red cell indices
OT  - beta-Thalassemia (beta-thal)
EDAT- 2015/06/16 06:00
MHDA- 2016/05/11 06:00
CRDT- 2015/06/16 06:00
PHST- 2015/06/16 06:00 [entrez]
PHST- 2015/06/16 06:00 [pubmed]
PHST- 2016/05/11 06:00 [medline]
AID - 10.3109/03630269.2015.1048352 [doi]
PST - ppublish
SO  - Hemoglobin. 2015;39(4):235-9. doi: 10.3109/03630269.2015.1048352. Epub 2015 Jun 
      15.