PMID- 26077330
OWN - NLM
STAT- MEDLINE
DCOM- 20161221
LR  - 20181113
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Print)
IS  - 2047-2404 (Linking)
VI  - 17
IP  - 3
DP  - 2016 Mar
TI  - Late gadolinium enhancement confined to the right ventricular insertion points in 
      hypertrophic cardiomyopathy: an intermediate stage phenotype?
PG  - 293-300
LID - 10.1093/ehjci/jev154 [doi]
AB  - AIMS: To investigate whether hypertrophic cardiomyopathy (HCM) patients with late 
      gadolinium enhancement (LGE) confined to the right ventricular insertion points 
      (RVIP) differ phenotypically from patients without LGE or intramural LGE in the 
      left ventricle (LV). METHODS AND RESULTS: Sixty-two HCM patients underwent 
      cardiac magnetic resonance for quantification of LGE (% LV mass) and were 
      classified as group (i) no-LGE (n = 18), group (ii) LGE-RVIP (n = 19), and group 
      (iii) intramural LGE (n = 25). All patients also underwent vasodilator N-13 
      ammonia PET to quantify myocardial blood flow (MBF) and myocardial flow reserve 
      (MFR), and echocardiography to measure longitudinal LV strain. LGE extent (17 +/- 
      11% vs. 4 +/- 4% vs. 0%; P < 0.001) and LV thickness (21.7 +/- 3.4 vs. 18.8 +/- 3.9 vs. 
      16.3 +/- 2.8 mm; P < 0.001) were significantly greater in group 3, intermediate in 
      group 2, and lower in group 1. In contrast, stress MBF (1.62 +/- 0.44 vs. 1.90 +/- 
      0.37 vs. 2.22 +/- 0.48 mL/min/g; P < 0.001); MFR (1.92 +/- 0.47 vs. 2.15 +/- 0.52 vs. 
      2.71 +/- 0.52; P < 0.001), and longitudinal LV strain (-11.4 +/- 3.8 vs. -12.6 +/- 3.2 
      vs. -14.4 +/- 4.1%; P = 0.04) were lower in group 3, intermediate in group 2, and 
      higher in group 1. CONCLUSIONS: From an imaging viewpoint, patients with LGE 
      confined to only the RVIP appear to represent an intermediate-stage phenotype 
      between patients with no LGE and intramural LGE in the LV.
CI  - Published on behalf of the European Society of Cardiology. All rights reserved. (c) 
      The Author 2015. For permissions please email: journals.permissions@oup.com.
FAU - Bravo, Paco E
AU  - Bravo PE
AD  - Department of Cardiology, University of Washington, 1959 NE Pacific Street, PO 
      Box 356422, Seattle, WA 98195, USA Johns Hopkins Medical Institutions, Baltimore, 
      MD, USA pbravo@uw.edu.
FAU - Luo, Hong-Chang
AU  - Luo HC
AD  - Johns Hopkins Medical Institutions, Baltimore, MD, USA.
FAU - Pozios, Iraklis
AU  - Pozios I
AD  - Johns Hopkins Medical Institutions, Baltimore, MD, USA.
FAU - Zimmerman, Stefan L
AU  - Zimmerman SL
AD  - Johns Hopkins Medical Institutions, Baltimore, MD, USA.
FAU - Corona-Villalobos, Celia Pamela
AU  - Corona-Villalobos CP
AD  - Johns Hopkins Medical Institutions, Baltimore, MD, USA.
FAU - Sorensen, Lars
AU  - Sorensen L
AD  - Johns Hopkins Medical Institutions, Baltimore, MD, USA.
FAU - Kamel, Ihab R
AU  - Kamel IR
AD  - Johns Hopkins Medical Institutions, Baltimore, MD, USA.
FAU - Bluemke, David A
AU  - Bluemke DA
AD  - National Institutes of Health, Bethesda, MD, USA.
FAU - Wahl, Richard L
AU  - Wahl RL
AD  - Johns Hopkins Medical Institutions, Baltimore, MD, USA.
FAU - Abraham, M Roselle
AU  - Abraham MR
AD  - Johns Hopkins Medical Institutions, Baltimore, MD, USA.
FAU - Abraham, Theodore P
AU  - Abraham TP
AD  - Johns Hopkins Medical Institutions, Baltimore, MD, USA.
LA  - eng
GR  - HL098046/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150614
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Cardiac-Gated Imaging Techniques
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging/*physiopathology
MH  - Contrast Media
MH  - Coronary Circulation
MH  - Echocardiography
MH  - Female
MH  - Gadolinium DTPA
MH  - Heart Ventricles/*diagnostic imaging/*physiopathology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Positron-Emission Tomography
PMC - PMC4750506
OTO - NOTNLM
OT  - CMR
OT  - LGE
OT  - RV insertion points
EDAT- 2015/06/17 06:00
MHDA- 2016/12/22 06:00
PMCR- 2017/03/01
CRDT- 2015/06/17 06:00
PHST- 2015/02/09 00:00 [received]
PHST- 2015/05/23 00:00 [accepted]
PHST- 2017/03/01 00:00 [pmc-release]
PHST- 2015/06/17 06:00 [entrez]
PHST- 2015/06/17 06:00 [pubmed]
PHST- 2016/12/22 06:00 [medline]
AID - jev154 [pii]
AID - 10.1093/ehjci/jev154 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2016 Mar;17(3):293-300. doi: 
      10.1093/ehjci/jev154. Epub 2015 Jun 14.