PMID- 26077775
OWN - NLM
STAT- MEDLINE
DCOM- 20160309
LR  - 20181113
IS  - 1615-6692 (Electronic)
IS  - 0340-9937 (Linking)
VI  - 40
IP  - 4
DP  - 2015 Jun
TI  - Arrhythmogenic right ventricular cardiomyopathy. Contribution of cardiac magnetic 
      resonance imaging to the diagnosis.
PG  - 600-6
LID - 10.1007/s00059-015-4228-0 [doi]
AB  - Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited disease of 
      the heart muscle, mostly due to genetically defective desmosomal proteins. The 
      disease is characterized by fibrofatty replacement leading to ventricular 
      arrhythmias and sudden death in young people and athletes. There is no single 
      clinical gold standard examination for making a definitive diagnosis. The 
      diagnosis is based on multiple parameters, including: (1) global or regional 
      dysfunction and structural alteration of the right ventricle demonstrated on 
      imaging; (2) tissue characterization by endomyocardial biopsy; (3) repolarization 
      and (4) depolarization electrocardiographic abnormalities; (5) arrhythmias; and 
      (6) family history. The so-called phenocopies must be included in the 
      differential diagnosis, always taking into account that there is no single 
      criterion sufficiently specific for a reliable diagnosis of ARVC. 
      Contrast-enhanced cardiac magnetic resonance imaging (CE-CMR) is not yet included 
      in the revised diagnostic criteria, although this is the only imaging modality 
      able to depict fibrosis as late gadolinium enhancement (LGE) deposition. This 
      review analyzes the role of CMR imaging in the diagnostic work-up of ARVC. The 
      lack of specific diagnostic criteria contributes to the under-recognition of the 
      nonclassic variants of ARVC, i.e., dominant or isolated left ventricular disease.
FAU - Perazzolo Marra, M
AU  - Perazzolo Marra M
AD  - Cardiovascular Pathology Unit, Department of Cardiac, Thoracic and Vascular 
      Sciences, University of Padua Medical School, Via Giustiniani 2, 35121, Padova, 
      Italy.
FAU - Rizzo, S
AU  - Rizzo S
FAU - Bauce, B
AU  - Bauce B
FAU - De Lazzari, M
AU  - De Lazzari M
FAU - Pilichou, K
AU  - Pilichou K
FAU - Corrado, D
AU  - Corrado D
FAU - Thiene, G
AU  - Thiene G
FAU - Iliceto, S
AU  - Iliceto S
FAU - Basso, C
AU  - Basso C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Herz
JT  - Herz
JID - 7801231
SB  - IM
MH  - Arrhythmogenic Right Ventricular Dysplasia/complications/*diagnosis
MH  - Diagnosis, Differential
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - *Stroke Volume
MH  - Ventricular Dysfunction, Right/*diagnosis/etiology
EDAT- 2015/06/17 06:00
MHDA- 2016/03/10 06:00
CRDT- 2015/06/17 06:00
PHST- 2015/06/17 06:00 [entrez]
PHST- 2015/06/17 06:00 [pubmed]
PHST- 2016/03/10 06:00 [medline]
AID - 10.1007/s00059-015-4228-0 [doi]
PST - ppublish
SO  - Herz. 2015 Jun;40(4):600-6. doi: 10.1007/s00059-015-4228-0.