PMID- 26078115
OWN - NLM
STAT- MEDLINE
DCOM- 20170717
LR  - 20181202
IS  - 1573-3254 (Electronic)
IS  - 1090-7165 (Print)
IS  - 1090-7165 (Linking)
VI  - 20
IP  - 7
DP  - 2016 Jul
TI  - Depression and Oral FTC/TDF Pre-exposure Prophylaxis (PrEP) Among Men and 
      Transgender Women Who Have Sex With Men (MSM/TGW).
PG  - 1478-88
LID - 10.1007/s10461-015-1082-2 [doi]
AB  - We conducted a longitudinal and cross-sectional analysis of depressive 
      symptomology in iPrEx, a randomized, placebo-controlled trial of daily, oral 
      FTC/TDF HIV pre-exposure prophylaxis (PrEP) in men and transgender women who have 
      sex with men. Depression-related adverse events (AEs) were the most frequently 
      reported severe or life-threatening AEs and were not associated with being 
      randomized to the FTC/TDF arm (152 vs. 144 respectively OR 0.66 95 % CI 
      0.35-1.25). Center for Epidemiologic Studies Depression scale (CES-D) and a four 
      questions suicidal ideation scale scores did not differ by arm. Participants 
      reporting forced sex at anal sexual debut had higher CES-D scores (coeff: 3.23; 
      95 % CI 1.24-5.23) and were more likely to have suicidal ideation (OR 2.2; 95 % 
      CI 1.09-4.26). CES-D scores were higher among people reporting non-condom 
      receptive anal intercourse (ncRAI) (OR 1.46; 95 % CI 1.09-1.94). We recommend 
      continuing PrEP during periods of depression in conjunction with provision of 
      mental health services.
FAU - Defechereux, Patricia A
AU  - Defechereux PA
AD  - J. David Gladstone Institutes, Grant Lab, GIVI, 5th Floor, 1650 Owens Street, San 
      Francisco, 94158, CA, USA.
FAU - Mehrotra, Megha
AU  - Mehrotra M
AD  - J. David Gladstone Institutes, Grant Lab, GIVI, 5th Floor, 1650 Owens Street, San 
      Francisco, 94158, CA, USA.
FAU - Liu, Albert Y
AU  - Liu AY
AD  - Bridge HIV, San Francisco Department of Public Health, San Francisco, CA, USA.
AD  - University of California, San Francisco, CA, USA.
FAU - McMahan, Vanessa M
AU  - McMahan VM
AD  - J. David Gladstone Institutes, Grant Lab, GIVI, 5th Floor, 1650 Owens Street, San 
      Francisco, 94158, CA, USA.
FAU - Glidden, David V
AU  - Glidden DV
AD  - University of California, San Francisco, CA, USA.
FAU - Mayer, Kenneth H
AU  - Mayer KH
AD  - Fenway Community Health, Boston, MA, USA.
FAU - Vargas, Lorena
AU  - Vargas L
AD  - Investigaciones Medicas en Salud, Lima, Peru.
FAU - Amico, K Rivet
AU  - Amico KR
AD  - School of Public Health, University of Michigan, Ann Arbor, MI, USA.
FAU - Chodacki, Piotr
AU  - Chodacki P
AD  - Desmond Tutu HIV Foundation, University of Cape Town, Cape Town, South Africa.
FAU - Fernandez, Telmo
AU  - Fernandez T
AD  - Fundacion Ecuatoriana Equidad, Guayaquil, Ecuador.
FAU - Avelino-Silva, Vivian I
AU  - Avelino-Silva VI
AD  - University of Sao Paulo Medical School, Sao Paulo, Brazil.
FAU - Burns, David
AU  - Burns D
AD  - National Institutes of Health, Bethesda, MD, USA.
FAU - Grant, Robert M
AU  - Grant RM
AD  - J. David Gladstone Institutes, Grant Lab, GIVI, 5th Floor, 1650 Owens Street, San 
      Francisco, 94158, CA, USA. robert.grant@ucsf.edu.
AD  - University of California, San Francisco, CA, USA. robert.grant@ucsf.edu.
AD  - San Francisco AIDS Foundation, San Francisco, CA, USA. robert.grant@ucsf.edu.
CN  - iPrEx Study Team
LA  - eng
GR  - R01 AI118575/AI/NIAID NIH HHS/United States
GR  - U01 AI064002/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - AIDS Behav
JT  - AIDS and behavior
JID - 9712133
RN  - 0 (Anti-HIV Agents)
RN  - 99YXE507IL (Tenofovir)
RN  - G70B4ETF4S (Emtricitabine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anti-HIV Agents/*administration & dosage
MH  - Cross-Sectional Studies
MH  - Depression/*diagnosis/psychology
MH  - Emtricitabine/administration & dosage
MH  - Female
MH  - HIV Infections/*prevention & control
MH  - Homosexuality, Male/*statistics & numerical data
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - *Pre-Exposure Prophylaxis
MH  - Sexual Behavior
MH  - Tenofovir/administration & dosage
MH  - Transgender Persons/*statistics & numerical data
PMC - PMC4903104
OTO - NOTNLM
OT  - Depression
OT  - FTC/TDF
OT  - HIV prevention
OT  - Men who have sex with men
OT  - PrEP
OT  - iPrEx
EDAT- 2015/06/17 06:00
MHDA- 2017/07/18 06:00
PMCR- 2015/06/16
CRDT- 2015/06/17 06:00
PHST- 2015/06/17 06:00 [entrez]
PHST- 2015/06/17 06:00 [pubmed]
PHST- 2017/07/18 06:00 [medline]
PHST- 2015/06/16 00:00 [pmc-release]
AID - 10.1007/s10461-015-1082-2 [pii]
AID - 1082 [pii]
AID - 10.1007/s10461-015-1082-2 [doi]
PST - ppublish
SO  - AIDS Behav. 2016 Jul;20(7):1478-88. doi: 10.1007/s10461-015-1082-2.