PMID- 26078977
OWN - NLM
STAT- MEDLINE
DCOM- 20160329
LR  - 20221207
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2015
DP  - 2015
TI  - Relationship of Soluble RAGE with Insulin Resistance and Beta Cell Function 
      during Development of Type 2 Diabetes Mellitus.
PG  - 150325
LID - 10.1155/2015/150325 [doi]
LID - 150325
AB  - This study examined whether circulating levels of soluble receptor for advanced 
      glycation end products (sRAGE) alter in prediabetes and correlate with insulin 
      resistance (IR) and beta cell function in prediabetes and newly diagnosed type 2 
      diabetes mellitus (T2DM). Subjects without previous history of diabetes were 
      recruited and grouped as control, prediabetes, and newly diagnosed T2DM. The 
      control subjects (n = 40) and people with prediabetes (n = 52) and diabetes (n = 
      66) were similar in terms of age, sex, BMI, systolic and diastolic BP, and 
      fasting insulin level. HOMA-IR was found significantly higher in people with 
      diabetes than control subjects (p < 0.001) and people with prediabetes (p = 
      0.005); and HOMA-%B was found significantly deteriorated in people with diabetes 
      (p < 0.001) compared to control subjects and people with prediabetes. However, 
      serum sRAGE levels did not show any significant alteration in people with 
      prediabetes compared to control subjects. Moreover, univariate and multivariate 
      analyses did not identify any significant correlation and statistical association 
      of sRAGE with HOMA-IR and HOMA-%B in people with prediabetes and newly diagnosed 
      T2DM. Our data suggest that serum sRAGE levels do not alter in people with 
      prediabetes compared to control subjects and do not correlate or associate with 
      IR and beta cell function during development of T2DM.
FAU - Biswas, Subrata Kumar
AU  - Biswas SK
AD  - Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU), 
      Shahbag, Dhaka 1000, Bangladesh.
FAU - Mohtarin, Sabreena
AU  - Mohtarin S
AD  - Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU), 
      Shahbag, Dhaka 1000, Bangladesh.
FAU - Mudi, Sonchita Rani
AU  - Mudi SR
AD  - Department of Biochemistry and Cell Biology, Bangladesh Institute of Research and 
      Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), 122 Kazi 
      Nazrul Islam Avenue, Shahbag, Dhaka 1000, Bangladesh.
FAU - Anwar, Taznuva
AU  - Anwar T
AD  - Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU), 
      Shahbag, Dhaka 1000, Bangladesh.
FAU - Banu, Laila Anjuman
AU  - Banu LA
AD  - Department of Anatomy, Bangabandhu Sheikh Mujib Medical University (BSMMU), 
      Shahbag, Dhaka 1000, Bangladesh.
FAU - Alam, Sheikh Md Khorshed
AU  - Alam SM
AD  - Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU), 
      Shahbag, Dhaka 1000, Bangladesh.
FAU - Fariduddin, Md
AU  - Fariduddin M
AD  - Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), 
      Shahbag, Dhaka 1000, Bangladesh.
FAU - Arslan, M Iqbal
AU  - Arslan MI
AD  - Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU), 
      Shahbag, Dhaka 1000, Bangladesh.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150519
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Receptor for Advanced Glycation End Products)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 0 (sRAGE protein, human)
SB  - IM
MH  - Adult
MH  - Bangladesh/epidemiology
MH  - Blood Glucose/analysis
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/diagnosis/epidemiology/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Insulin/blood/*metabolism
MH  - *Insulin Resistance
MH  - Insulin Secretion
MH  - Insulin-Secreting Cells/*metabolism
MH  - Linear Models
MH  - Male
MH  - Mass Screening
MH  - Middle Aged
MH  - Prediabetic State/blood/*metabolism
MH  - Receptor for Advanced Glycation End Products/*blood
MH  - Risk
MH  - Young Adult
PMC - PMC4452360
EDAT- 2015/06/17 06:00
MHDA- 2016/03/30 06:00
PMCR- 2015/05/19
CRDT- 2015/06/17 06:00
PHST- 2015/04/14 00:00 [received]
PHST- 2015/05/12 00:00 [accepted]
PHST- 2015/06/17 06:00 [entrez]
PHST- 2015/06/17 06:00 [pubmed]
PHST- 2016/03/30 06:00 [medline]
PHST- 2015/05/19 00:00 [pmc-release]
AID - 10.1155/2015/150325 [doi]
PST - ppublish
SO  - J Diabetes Res. 2015;2015:150325. doi: 10.1155/2015/150325. Epub 2015 May 19.