PMID- 26079055
OWN - NLM
STAT- MEDLINE
DCOM- 20151020
LR  - 20161125
IS  - 1872-7786 (Electronic)
IS  - 0009-2797 (Linking)
VI  - 238
DP  - 2015 Aug 5
TI  - The therapeutic detoxification of chlorogenic acid against acetaminophen-induced 
      liver injury by ameliorating hepatic inflammation.
PG  - 93-101
LID - S0009-2797(15)00242-2 [pii]
LID - 10.1016/j.cbi.2015.05.023 [doi]
AB  - Chlorogenic acid (CGA) has been reported to prevent acetaminophen (AP)-induced 
      hepatotoxicity when mice were pre-administered orally with CGA for consecutive 
      7days before AP intoxication in our previous study. This study investigated the 
      therapeutic detoxification of CGA against AP-induced hepatotoxicity and the 
      engaged mechanism. The mice were orally administered with CGA (10, 20, 40mg/kg) 
      at 1h after given AP (400mg/kg), and another 3h later the mice were killed for 
      the following experiments. Results of serum transaminases analysis and 
      histological evaluation demonstrated the detoxification of CGA against AP-induced 
      hepatotoxicity. CGA reduced AP-induced the increased myeloperoxidase (MPO) 
      enzymatic activity and its expression. CGA reduced AP-induced the increased liver 
      expression of toll-like receptor (TLR)-3/4 and MyD88, and the increased 
      phosphorylation of inhibitor of kappa B (IkappaB) and p65 subunit of nuclear factor 
      kappaB (NFkappaB). CGA reduced AP-induced the increased NFkappaBp65 expression in nucleus. In 
      addition, CGA reduced AP-induced the increased serum levels and liver mRNA 
      expression of tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1beta, IL-6, 
      monocyte chemoattractant protein-1 (MCP-1), and keratinocyte chemoattractant 
      (KC). Taken together, our results demonstrate the therapeutic detoxification of 
      CGA against AP-induced liver injury, and TLR3/4 and NFkappaB signaling pathway are 
      involved in such process.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Zheng, Zhiyong
AU  - Zheng Z
AD  - The Shanghai Key Laboratory of Complex Prescription, The MOE Key Laboratory for 
      Standardization of Chinese Medicines, and The SATCM Key Laboratory for New 
      Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese 
      Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 
      201203, China.
FAU - Sheng, Yuchen
AU  - Sheng Y
AD  - Center for Drug Safety Evaluation and Research, Shanghai University of 
      Traditional Chinese Medicine, Shanghai 201203, China.
FAU - Lu, Bing
AU  - Lu B
AD  - The Shanghai Key Laboratory of Complex Prescription, The MOE Key Laboratory for 
      Standardization of Chinese Medicines, and The SATCM Key Laboratory for New 
      Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese 
      Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 
      201203, China.
FAU - Ji, Lili
AU  - Ji L
AD  - The Shanghai Key Laboratory of Complex Prescription, The MOE Key Laboratory for 
      Standardization of Chinese Medicines, and The SATCM Key Laboratory for New 
      Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese 
      Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 
      201203, China. Electronic address: lichenyue1307@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150612
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (Cytokines)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (RNA, Messenger)
RN  - 0 (TLR3 protein, mouse)
RN  - 0 (Tlr4 protein, mouse)
RN  - 0 (Toll-Like Receptor 3)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Transcription Factor RelA)
RN  - 318ADP12RI (Chlorogenic Acid)
RN  - 362O9ITL9D (Acetaminophen)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - EC 2.7.11.10 (I-kappa B Kinase)
SB  - IM
MH  - Acetaminophen/toxicity
MH  - Administration, Oral
MH  - Alanine Transaminase/blood
MH  - Animals
MH  - Aspartate Aminotransferases/blood
MH  - Chemical and Drug Induced Liver Injury/pathology/*prevention & control
MH  - Chlorogenic Acid/pharmacology/*therapeutic use
MH  - Cytokines/genetics/metabolism
MH  - I-kappa B Kinase/metabolism
MH  - *Inflammation
MH  - Liver/enzymology/metabolism/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Myeloid Differentiation Factor 88/metabolism
MH  - Peroxidase/metabolism
MH  - RNA, Messenger/metabolism
MH  - Signal Transduction/drug effects
MH  - Toll-Like Receptor 3/metabolism
MH  - Toll-Like Receptor 4/metabolism
MH  - Transcription Factor RelA/metabolism
OTO - NOTNLM
OT  - Acetaminophen
OT  - Chlorogenic acid
OT  - Detoxification
OT  - Hepatic inflammation
OT  - NFkappaB
OT  - TLR3/4
EDAT- 2015/06/17 06:00
MHDA- 2015/10/21 06:00
CRDT- 2015/06/17 06:00
PHST- 2014/12/17 00:00 [received]
PHST- 2015/05/12 00:00 [revised]
PHST- 2015/05/26 00:00 [accepted]
PHST- 2015/06/17 06:00 [entrez]
PHST- 2015/06/17 06:00 [pubmed]
PHST- 2015/10/21 06:00 [medline]
AID - S0009-2797(15)00242-2 [pii]
AID - 10.1016/j.cbi.2015.05.023 [doi]
PST - ppublish
SO  - Chem Biol Interact. 2015 Aug 5;238:93-101. doi: 10.1016/j.cbi.2015.05.023. Epub 
      2015 Jun 12.