PMID- 26079571
OWN - NLM
STAT- MEDLINE
DCOM- 20151009
LR  - 20181202
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 570
IP  - 1
DP  - 2015 Oct 1
TI  - Control of bone development by P2X and P2Y receptors expressed in mesenchymal and 
      hematopoietic cells.
PG  - 1-7
LID - S0378-1119(15)00739-8 [pii]
LID - 10.1016/j.gene.2015.06.031 [doi]
AB  - Bone development and homeostasis require the interplay between several cell 
      types, including mesenchymal osteoblasts and osteocytes, as well as hematopoietic 
      osteoclasts. Recent evidence suggests that cell proliferation, differentiation 
      and apoptosis of both mesenchymal and hematopoietic stem cells, which are 
      fundamental for tissue regeneration and treatment of degenerative diseases, are 
      controlled by P2 receptors (i.e., P2X and P2Y receptors). Both types of P2 
      receptors are versatile transducers of diverse signals activated by extracellular 
      nucleotides like ATP that are released in response to tissue injury, infection or 
      shear stress. The P2X family of receptors has been shown to mediate multiple 
      signaling events including the influx of calcium, activation of mitogen activated 
      protein kinases (MAPKs) and induction of AP-1 family members known to regulate 
      bone development. Support for the significance of P2X7 in regulating bone 
      development and homeostasis has been provided by several studies focusing on 
      animal models and single nucleotide polymorphisms. P2 receptors are functionally 
      expressed in both bone forming osteoblasts and bone resorbing osteoclasts, while 
      recent findings also suggest that these receptors translate mechanical stimuli in 
      osteocytes. Their ability to respond to external nucleotide analogs renders these 
      cell surface proteins excellent targets for skeletal regenerative therapies. This 
      overview summarizes mechanisms by which nucleotide receptors control skeletal 
      cells and contribute to bone tissue development remodeling and repair.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Lenertz, Lisa Y
AU  - Lenertz LY
AD  - Department of Biology, St. Olaf College, Northfield, MN, USA.
FAU - Baughman, Cory J
AU  - Baughman CJ
AD  - Department of Biology, St. Olaf College, Northfield, MN, USA.
FAU - Waldschmidt, Noelle V
AU  - Waldschmidt NV
AD  - Department of Biology, St. Olaf College, Northfield, MN, USA.
FAU - Thaler, Roman
AU  - Thaler R
AD  - Departments of Orthopedic Surgery and Biochemistry and Molecular Biology, Mayo 
      Clinic, Rochester, MN, USA.
FAU - van Wijnen, Andre J
AU  - van Wijnen AJ
AD  - Departments of Orthopedic Surgery and Biochemistry and Molecular Biology, Mayo 
      Clinic, Rochester, MN, USA. Electronic address: vanwijnen.andre@mayo.edu.
LA  - eng
GR  - R01 AR049069/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150614
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Receptors, Purinergic P2X)
RN  - 0 (Receptors, Purinergic P2Y)
SB  - IM
MH  - Animals
MH  - *Bone Development
MH  - Hematopoietic Stem Cells/*physiology
MH  - Humans
MH  - Mesenchymal Stem Cells/*physiology
MH  - Osteoblasts/metabolism
MH  - Osteoclasts/metabolism
MH  - Osteogenesis
MH  - Receptors, Purinergic P2X/*physiology
MH  - Receptors, Purinergic P2Y/*physiology
MH  - Signal Transduction
PMC - PMC5268819
MID - NIHMS707497
OTO - NOTNLM
OT  - Bone
OT  - Mesenchymal stem cell
OT  - Osteoblast
OT  - Osteogenesis
COIS- Not applicable.
EDAT- 2015/06/17 06:00
MHDA- 2015/10/10 06:00
PMCR- 2017/01/26
CRDT- 2015/06/17 06:00
PHST- 2015/03/15 00:00 [received]
PHST- 2015/06/05 00:00 [revised]
PHST- 2015/06/06 00:00 [accepted]
PHST- 2015/06/17 06:00 [entrez]
PHST- 2015/06/17 06:00 [pubmed]
PHST- 2015/10/10 06:00 [medline]
PHST- 2017/01/26 00:00 [pmc-release]
AID - S0378-1119(15)00739-8 [pii]
AID - 10.1016/j.gene.2015.06.031 [doi]
PST - ppublish
SO  - Gene. 2015 Oct 1;570(1):1-7. doi: 10.1016/j.gene.2015.06.031. Epub 2015 Jun 14.