PMID- 26080582
OWN - NLM
STAT- MEDLINE
DCOM- 20150714
LR  - 20181023
IS  - 0042-465X (Print)
IS  - 0042-465X (Linking)
VI  - 131
IP  - 2
DP  - 2015 Mar-Apr
TI  - [Surgical treatment for optic neuropathy in high myopia].
PG  - 45-49
LID - 10.17116/oftalma2015131245-49 [doi]
AB  - AIM: To improve the effectiveness of surgical treatment for optic neuropathy in 
      high-degree myopia. MATERIAL AND METHODS: A total of 54 patients (96 eyes) aged 
      18-30 with high myopia and signs of optic neuropathy were observed. The main 
      group consisted of 20 patients (28 eyes) who underwent meridional scleral 
      reinforcement with type I collagen-based implant placed over the posterior 
      segment. The control group included 34 patients (68 eyes) who were given a 10-day 
      vitamin and vascular therapy course. In most of the controls (21 patient, 21 
      eyes) indirect revascularization with ligation of the superficial temporal artery 
      was performed. Ophthalmological examination was done before the beginning of the 
      treatment and then at 1, 6, and 12 months. Results. At the end of the follow-up 
      period best corrected visual acuity in the main group was 19.2% higher, on 
      average, than baseline values, but remained unchanged in the controls. Light 
      sensitivity of the retina in both group increased by 7% and 2% respectively. 
      Electrically evoked phosphene thresholds decreased by 22.5% and 10.4% 
      respectively. The main group also demonstrated a near-constant mean peripapillary 
      nerve fiber layer (RNFL) thickness and a 16.4% higher than baseline blood flow 
      velocity in the ophthalmic artery. In the control group the latter parameter 
      showed no change. CONCLUSIONS: Scleral reinforcement surgery in patients with 
      high myopia complicated by optic neuropathy enables improvement of visual 
      functions and regional blood flow as well as stabilization of RNFL thickness and 
      volume, thus, preventing subsequent development of optic nerve atrophy.
FAU - Zavgorodnyaya, N G
AU  - Zavgorodnyaya NG
AD  - Zaporizhzhya Medical Academy of Postgraduate Education, 20 bulvar Vintera, 
      Zaporizhzhya, Ukraine, 69096.
FAU - Denisova, O O
AU  - Denisova OO
AD  - Zaporizhzhya Medical Academy of Postgraduate Education, 20 bulvar Vintera, 
      Zaporizhzhya, Ukraine, 69096.
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Vestn Oftalmol
JT  - Vestnik oftalmologii
JID - 0415216
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Adult
MH  - Collagen/therapeutic use
MH  - Diagnostic Techniques, Ophthalmological
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - *Myopia/complications/diagnosis
MH  - *Optic Nerve Diseases/diagnosis/etiology/surgery
MH  - Prostheses and Implants
MH  - *Scleroplasty/instrumentation/methods
MH  - Treatment Outcome
EDAT- 2015/06/18 06:00
MHDA- 2015/07/15 06:00
CRDT- 2015/06/18 06:00
PHST- 2015/06/18 06:00 [entrez]
PHST- 2015/06/18 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.17116/oftalma2015131245-49 [doi]
PST - ppublish
SO  - Vestn Oftalmol. 2015 Mar-Apr;131(2):45-49. doi: 10.17116/oftalma2015131245-49.