PMID- 26081100
OWN - NLM
STAT- MEDLINE
DCOM- 20160728
LR  - 20181202
IS  - 1613-4133 (Electronic)
IS  - 1613-4125 (Linking)
VI  - 59
IP  - 9
DP  - 2015 Sep
TI  - Coenzyme Q10 consumption promotes ABCG1-mediated macrophage cholesterol efflux: a 
      randomized, double-blind, placebo-controlled, cross-over study in healthy 
      volunteers.
PG  - 1725-34
LID - 10.1002/mnfr.201500186 [doi]
AB  - SCOPE: We have recently shown that coenzyme Q10 (CoQ10) enhances macrophage 
      reverse cholesterol transport via activator protein-1/miRNA-378/ABCG1 signal 
      pathway in vivo and in vitro. Whether CoQ10 exerts similar beneficial effects in 
      human is currently unknown. The present study evaluated the effect of CoQ10 on 
      ABCG1-mediated macrophage cholesterol efflux in 20 healthy volunteers. METHODS 
      AND RESULTS: Participants were given 100 mg CoQ10 twice daily or placebo for 1 
      week with a 1-week washout period. Human monocyte-derived macrophages (MDMs) were 
      differentiated under pooled sera obtained before (preCoQ10) or after CoQ10 
      (postCoQ10) consumption. The CoQ10-induced inhibition of MDMs foam cell formation 
      was blocked by ABCG1 silencing in postCoQ10 MDMs incubated with postCoQ10 sera 
      compared to preCoQ10 sera. The cholesterol efflux to HDL, and mRNA as well as 
      protein expressions of ATP-binding cassette transporter G1 (ABCG1) were augmented 
      in postCoQ10 MDMs incubated with postCoQ10 sera compared to preCoQ10 sera. The 
      change in the serum CoQ10 concentration positively correlated with cholesterol 
      efflux to HDL and ABCG1 mRNA level in the CoQ10 group. MDMs treated with purified 
      CoQ10 had an enhanced cholesterol efflux to HDL. CONCLUSION: CoQ10 consumption 
      may have an atheroprotective property by inducing ABCG1 expression and enhancing 
      HDL-mediated macrophage cholesterol efflux in healthy individuals.
CI  - (c) 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Yan, Xiao
AU  - Yan X
AD  - Department of Nutrition and Food Hygiene, Center for Prevention and Control of 
      Non-communicable Chronic Diseases, School of Public Health, Dalian Medical 
      University, Dalian, P. R. China.
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated 
      Hospital of Dalian Medical University, Dalian, P. R. China.
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, P. 
      R. China.
FAU - Shen, Tianran
AU  - Shen T
AD  - Department of Nutrition, School of Public Health, Sun Yat-sen University, 
      Guangzhou, P. R. China.
FAU - Jiang, Xinwei
AU  - Jiang X
AD  - Department of Nutrition, School of Public Health, Sun Yat-sen University, 
      Guangzhou, P. R. China.
FAU - Tang, Xilan
AU  - Tang X
AD  - Department of Nutrition, School of Public Health, Sun Yat-sen University, 
      Guangzhou, P. R. China.
FAU - Wang, Dongliang
AU  - Wang D
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, P. 
      R. China.
AD  - Department of Nutrition, School of Public Health, Sun Yat-sen University, 
      Guangzhou, P. R. China.
FAU - Li, Huihua
AU  - Li H
AD  - Department of Nutrition and Food Hygiene, Center for Prevention and Control of 
      Non-communicable Chronic Diseases, School of Public Health, Dalian Medical 
      University, Dalian, P. R. China.
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated 
      Hospital of Dalian Medical University, Dalian, P. R. China.
FAU - Ling, Wenhua
AU  - Ling W
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, P. 
      R. China.
AD  - Department of Nutrition, School of Public Health, Sun Yat-sen University, 
      Guangzhou, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150701
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (ABCG1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 1)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (RNA, Messenger)
RN  - 1339-63-5 (Ubiquinone)
RN  - EJ27X76M46 (coenzyme Q10)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily G, Member 1
MH  - ATP-Binding Cassette Transporters/genetics/*metabolism
MH  - Cell Differentiation/drug effects
MH  - Cells, Cultured
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - Cross-Over Studies
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Female
MH  - Foam Cells/*drug effects/metabolism
MH  - Gene Expression Regulation
MH  - Gene Silencing
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - RNA, Messenger/genetics/metabolism
MH  - Signal Transduction
MH  - Ubiquinone/administration & dosage/*analogs & derivatives/blood
MH  - Young Adult
OTO - NOTNLM
OT  - ABCG1
OT  - Atherosclerosis
OT  - Coenzyme Q10
OT  - Cross-over study
OT  - Macrophage cholesterol efflux
EDAT- 2015/06/18 06:00
MHDA- 2016/07/29 06:00
CRDT- 2015/06/18 06:00
PHST- 2015/03/10 00:00 [received]
PHST- 2015/05/06 00:00 [revised]
PHST- 2015/06/07 00:00 [accepted]
PHST- 2015/06/18 06:00 [entrez]
PHST- 2015/06/18 06:00 [pubmed]
PHST- 2016/07/29 06:00 [medline]
AID - 10.1002/mnfr.201500186 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2015 Sep;59(9):1725-34. doi: 10.1002/mnfr.201500186. Epub 2015 
      Jul 1.