PMID- 26081206
OWN - NLM
STAT- MEDLINE
DCOM- 20160223
LR  - 20221207
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 95
IP  - 14
DP  - 2015 Apr 14
TI  - [Glucose characteristics in normal glucose tolerance subjects with metabolic 
      syndrome].
PG  - 1070-3
AB  - OBJECTIVE: To explore the characteristics of glycemic variability in normal 
      glucose tolerance (NGT) subjects with metabolic syndrome (MetS). METHODS: A total 
      of 40 NGT subjects diagnosed by oral glucose tolerance test (OGTT) were divided 
      into two groups of metabolic syndrome (MetS) or without MetS (Non-MetS) according 
      to the National Cholesterol Education Program-Adult Treatment Panel III 
      (NCEP-ATPIII) criteria. Fasting blood glucose (FBG), OGTT 2 h blood glucose (2 h 
      BG), hemoglobin A1c (HbA1c) and glycemic variability were assessed. Glycemic 
      variability was assessed by calculating standard deviation of MBG (SDBG), mean 
      amplitude of glycemic excursions (MAGE), largest amplitude of glycemic excursions 
      (LAGE) and means of daily differences (MODD) from the 72 h data of continuous 
      glucose monitoring system (CGMS) in real life. The time of diurnal glycemic 
      variability was also calculated. RESULTS: No significant inter-group difference 
      existed in FBG, 2 h BG or HbA1c. Glycemic variability was higher in MetS than 
      that in Non-MetS group. But only MAGE (2.12+/-0.92 vs 1.50+/-0.68 mmol/L, P=0.02) 
      showed significant inter-group difference. Logistic regression analysis revealed 
      that MAGE was significantly correlated with MetS (OR=2.74, 95% CI: 1.08-6.97, 
      P=0.03) and independently from FBG, PBG, HbA1c and other glycemic variability 
      indices. CONCLUSIONS: Glycemic variability increases in NGT subjects with MetS. 
      And MAGE may better describe the population's glucose metabolism.
FAU - Yang, Xubin
AU  - Yang X
AD  - Department of Endocrinology & Metabolism, Third Affiliated Hospital, Sun Yat-sen 
      University, Guangzhou 510630, China.
FAU - Zhu, Yanhua
AU  - Zhu Y
AD  - Department of Endocrinology & Metabolism, Third Affiliated Hospital, Sun Yat-sen 
      University, Guangzhou 510630, China.
FAU - Luo, Sihui
AU  - Luo S
AD  - Department of Endocrinology & Metabolism, Third Affiliated Hospital, Sun Yat-sen 
      University, Guangzhou 510630, China.
FAU - Chen, Lin
AU  - Chen L
AD  - Department of Endocrinology & Metabolism, Third Affiliated Hospital, Sun Yat-sen 
      University, Guangzhou 510630, China.
FAU - Yan, Jinhua
AU  - Yan J
AD  - Department of Endocrinology & Metabolism, Third Affiliated Hospital, Sun Yat-sen 
      University, Guangzhou 510630, China.
FAU - Zeng, Longyi
AU  - Zeng L
AD  - Department of Endocrinology & Metabolism, Third Affiliated Hospital, Sun Yat-sen 
      University, Guangzhou 510630, China.
FAU - Xu, Wen
AU  - Xu W
AD  - Department of Endocrinology & Metabolism, Third Affiliated Hospital, Sun Yat-sen 
      University, Guangzhou 510630, China; Email: xwen@mail.sysu.edu.cn.
FAU - Weng, Jianping
AU  - Weng J
AD  - Department of Endocrinology & Metabolism, Third Affiliated Hospital, Sun Yat-sen 
      University, Guangzhou 510630, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Blood Glucose
MH  - Glucose
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin
MH  - Humans
MH  - *Metabolic Syndrome
EDAT- 2015/06/18 06:00
MHDA- 2016/02/26 06:00
CRDT- 2015/06/18 06:00
PHST- 2015/06/18 06:00 [entrez]
PHST- 2015/06/18 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2015 Apr 14;95(14):1070-3.