PMID- 26081770
OWN - NLM
STAT- MEDLINE
DCOM- 20160926
LR  - 20181202
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 23
IP  - 3
DP  - 2016 Feb
TI  - Trends in the enantiomeric composition of polychlorinated biphenyl atropisomers 
      in human breast milk.
PG  - 2027-32
LID - 10.1007/s11356-015-4620-6 [doi]
AB  - For the precise estimation of the risk to human health caused by persistent 
      organic pollutants (POPs), it is important to discuss enantiomer fraction value 
      (EF value) because it is reported that behaviors such as stability and toxicity 
      of enantiomers are quite different in human body. Among POPs, polychlorinated 
      biphenyl (PCB) is known as one of the most persistent compounds in human breast 
      milk samples. The main exposure source of PCB for human body is mostly from food 
      especially in seafood. The contamination of fish and shellfish has been a serious 
      problem for the Japanese, who consume a large amount of fish in their diet. PCBs 
      have 19 congeners which are chlorine-substituted in 3- or 4- ortho positions are 
      known to have enantiomers. In this study, we analyzed PCB 183 
      (2,2',3,4,4',5',6-hepta CB) in human breast milk and fish samples 
      enantioselectively and revealed the time trends of the EF value. Though EF value 
      of PCB 183 in fish samples sustained close to racemate (EF = 0.5) from 1982 to 
      2012, that in breast milk increased over time. This fact indicates that 
      (+)-PCB-183 has greater bioaccumulation potential than (-)-PCB-183 in human body; 
      therefore, the toxicity of (+)-PCB-183 should be emphasized.
FAU - Konishi, Yoshimasa
AU  - Konishi Y
AD  - Osaka Prefectural Institute of Public Health, 1-3-69, Nakamichi, Higashinari-ku, 
      537-0025, Osaka, Japan. konisi@iph.pref.osaka.jp.
FAU - Kakimoto, Kensaku
AU  - Kakimoto K
AD  - Osaka Prefectural Institute of Public Health, 1-3-69, Nakamichi, Higashinari-ku, 
      537-0025, Osaka, Japan.
FAU - Nagayoshi, Haruna
AU  - Nagayoshi H
AD  - Osaka Prefectural Institute of Public Health, 1-3-69, Nakamichi, Higashinari-ku, 
      537-0025, Osaka, Japan.
FAU - Nakano, Takeshi
AU  - Nakano T
AD  - Research Center for Environmental Preservation, Osaka University, 2-4, Yamadaoka, 
      Suita, Osaka, 565-0871, Japan.
LA  - eng
PT  - Journal Article
DEP - 20150618
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - *Diet
MH  - Female
MH  - Fishes
MH  - Food Contamination/*analysis
MH  - Humans
MH  - Milk, Human/*chemistry
MH  - Polychlorinated Biphenyls/*chemistry/*metabolism
MH  - Seafood
MH  - Stereoisomerism
MH  - Water Pollutants, Chemical/*chemistry/metabolism
OTO - NOTNLM
OT  - 2,2',3,4,4',5',6-hepta CB
OT  - Enantiomer fraction value
OT  - Enantiomer selective analysis
OT  - High resolution gas chromatography/high resolution mass chromatography
OT  - Human breast milk
OT  - Market basket study
EDAT- 2015/06/18 06:00
MHDA- 2016/09/27 06:00
CRDT- 2015/06/18 06:00
PHST- 2015/02/15 00:00 [received]
PHST- 2015/04/27 00:00 [accepted]
PHST- 2015/06/18 06:00 [entrez]
PHST- 2015/06/18 06:00 [pubmed]
PHST- 2016/09/27 06:00 [medline]
AID - 10.1007/s11356-015-4620-6 [pii]
AID - 10.1007/s11356-015-4620-6 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2016 Feb;23(3):2027-32. doi: 
      10.1007/s11356-015-4620-6. Epub 2015 Jun 18.