PMID- 26081778
OWN - NLM
STAT- MEDLINE
DCOM- 20170727
LR  - 20191210
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 24
IP  - 5
DP  - 2017 Feb
TI  - Periodic monitoring of persistent organic pollutants and molecular damage in 
      Cyprinus carpio from Buyuk Menderes River.
PG  - 4241-4251
LID - 10.1007/s11356-015-4848-1 [doi]
AB  - Concentrations of persistent organic pollutants (POPs) were quantified in river 
      water and sediment, as well as in the liver and muscle tissues of Cyprinus carpio 
      that were sampled four times in a year at three stations in the Buyuk Menderes 
      River (BMR). Potential biomarkers of possible cellular molecular damage, namely 
      lipid peroxidation (LPO) degradation products, protein carbonyls (PCO) and DNA 
      repair product 8-hydroxy-2'-deoxyguanosine (8-OHdG), were analysed. All the 
      targeted pollutants were measurable both in biotic and abiotic samples. 
      Interestingly, the results suggested that there was recent organochlorine 
      pesticide (OCP) input into the river water in the first two sampling periods in 
      all stations in contrast to prohibition, while input of polychlorinated biphenyls 
      (PCBs) and polybrominated diphenylethers (PBDEs) was not detected. Liver POP 
      concentrations were higher than in muscle, as expected, and were found to 
      decrease from the first to the fourth sampling period in all stations, except 
      PBDEs. Levels of LPO degradation products in the liver and in muscle tissues 
      decreased from the first to the fourth sampling period. This suggests that these 
      markers reflect the lipid damage in respective tissues due to the tissue burden 
      of targeted POPs. Protein carbonyls were the highest in the first sampling 
      period, followed by a dramatic decrease in the second, and then a gradual 
      increase towards the fourth sampling period in all stations. 8-OHdG levels were 
      lower in Saraykoy station in the first sampling period. Among the measured 
      biomarkers, only several LPO degradation products were significantly correlated 
      with OCPs and PCBs in liver tissue.
FAU - Cagdas, Beste
AU  - Cagdas B
AD  - Department of Toxicology, Faculty of Pharmacy, Ege University, 35100, 
      Bornova-Izmir, Turkey.
AD  - Bioengineering Department, Faculty of Engineering, Kirikkale University, 71450, 
      Merkez-Kirikkale, Turkey.
FAU - Kocagoz, Rasih
AU  - Kocagoz R
AD  - Department of Toxicology, Faculty of Pharmacy, Ege University, 35100, 
      Bornova-Izmir, Turkey.
FAU - Onat, Ilgen
AU  - Onat I
AD  - Department of Toxicology, Faculty of Pharmacy, Ege University, 35100, 
      Bornova-Izmir, Turkey.
FAU - Percin, Fatih
AU  - Percin F
AD  - Department of Aquaculture, Faculty of Fisheries, Ege University, 35100, 
      Bornova-Izmir, Turkey.
FAU - Ozaydin, Okan
AU  - Ozaydin O
AD  - Department of Hydrobiology, Faculty of Fisheries, Ege University, 35100, 
      Bornova-Izmir, Turkey.
FAU - Orhan, Hilmi
AU  - Orhan H
AD  - Department of Toxicology, Faculty of Pharmacy, Ege University, 35100, 
      Bornova-Izmir, Turkey. horhan@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20150617
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 0 (Water Pollutants, Chemical)
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
RN  - G9481N71RO (Deoxyguanosine)
SB  - IM
MH  - 8-Hydroxy-2'-Deoxyguanosine
MH  - Animals
MH  - *Carps
MH  - Deoxyguanosine/analogs & derivatives
MH  - Environmental Monitoring
MH  - Hydrocarbons, Chlorinated/analysis
MH  - Pesticides/analysis
MH  - Rivers/*chemistry
MH  - Water Pollutants, Chemical/*analysis
OTO - NOTNLM
OT  - Buyuk Menderes River
OT  - Cyprinus carpio
OT  - DNA damage
OT  - Lipid peroxidation degradation products
OT  - POPs
OT  - Protein carbonyls
EDAT- 2015/06/18 06:00
MHDA- 2017/07/28 06:00
CRDT- 2015/06/18 06:00
PHST- 2015/03/09 00:00 [received]
PHST- 2015/06/05 00:00 [accepted]
PHST- 2015/06/18 06:00 [pubmed]
PHST- 2017/07/28 06:00 [medline]
PHST- 2015/06/18 06:00 [entrez]
AID - 10.1007/s11356-015-4848-1 [pii]
AID - 10.1007/s11356-015-4848-1 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2017 Feb;24(5):4241-4251. doi: 
      10.1007/s11356-015-4848-1. Epub 2015 Jun 17.