PMID- 26083111
OWN - NLM
STAT- MEDLINE
DCOM- 20160503
LR  - 20221207
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 7
IP  - 6
DP  - 2015 Jun 15
TI  - Association of Canonical Wnt/beta-Catenin Pathway and Type 2 Diabetes: Genetic 
      Epidemiological Study in Han Chinese.
PG  - 4763-77
LID - 10.3390/nu7064763 [doi]
AB  - We aimed to investigate the associations of polymorphisms in Canonical 
      Wnt/beta-catenin pathway (WNT) signaling genes (including low-density 
      lipoprotein-related protein 5 [LRP5] and transcription factor 7-like 2 [TCF7L2] 
      gene) and the downstream gene glucagon (GCG) and risk of type 2 diabetes mellitus 
      (T2DM) in a Han Chinese population. We genotyped the single nucleotide 
      polymorphisms (SNPs) for LRP5, TCF7L2 and GCG gene were genotyped in 1842 
      patients with T2DM and 7777 normal glucose-tolerant healthy subjects. We used 
      multifactor dimensionality reduction (MDR) and multiplicative logistic regression 
      adjusting for sex, age, anthropometric measurements and lipid levels to 
      investigate the gene-gene interactions for the risk of T2DM. Among the five SNPs 
      in LRP5, the recessive model of rs7102273 and the haplotype GCTCC were associated 
      with T2DM risk; the haplotype GCTTC was associated with decreased risk. For 
      TCF7L2, the rs11196218 genotype GA and the haplotype CCG, TTG, TTA were 
      associated with T2DM risk; whereas, the haplotype CTG and TCG were associated 
      with decreased risk. Both MDR and multiplicative logistic regression revealed 
      potential gene-gene interactions among LRP5, TCF7L2, and GCG associated with 
      T2DM. The WNT signaling pathway may play a significant role in risk of T2DM in 
      Han Chinese people.
FAU - Wang, Jinjin
AU  - Wang J
AD  - Department of Traditional Chinese Medicine Prevention, Preventive Medicine 
      Research Evaluation Center, Henan University of Traditional Chinese Medicine, 
      Zhengzhou 450008, China. wangjinjin510@yahoo.com.
AD  - Department of Epidemiology, Shenzhen University School of Medicine, Shenzhen 
      518060, China. wangjinjin510@yahoo.com.
FAU - Zhao, Jingzhi
AU  - Zhao J
AD  - Military Hospital of Henan Province, Zhengzhou 450000, China. 
      jingzhi_zhao@sina.com.
FAU - Zhang, Jianfeng
AU  - Zhang J
AD  - Henan Armed Police Corps Hospital, Zhengzhou 450000, China. 
      jeefzhang106@yahoo.com.
FAU - Luo, Xinping
AU  - Luo X
AD  - Department of Epidemiology, Shenzhen University School of Medicine, Shenzhen 
      518060, China. lxp2005@szu.edu.cn.
FAU - Gao, Kaiping
AU  - Gao K
AD  - Department of Epidemiology, Shenzhen University School of Medicine, Shenzhen 
      518060, China. gao_kp@szu.edu.cn.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Department of Epidemiology, Shenzhen University School of Medicine, Shenzhen 
      518060, China. zhangming@szu.edu.cn.
FAU - Li, Linlin
AU  - Li L
AD  - Department of Epidemiology, College of Public Health, Zhengzhou University, 
      Zhengzhou 450001, China. lilinlin@zzu.edu.cn.
FAU - Wang, Chongjian
AU  - Wang C
AD  - Department of Epidemiology, College of Public Health, Zhengzhou University, 
      Zhengzhou 450001, China. jwcj2008@zzu.edu.cn.
FAU - Hu, Dongsheng
AU  - Hu D
AD  - Department of Epidemiology, Shenzhen University School of Medicine, Shenzhen 
      518060, China. dongsheng_hu@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150615
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (LRP5 protein, human)
RN  - 0 (Low Density Lipoprotein Receptor-Related Protein-5)
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
RN  - 0 (beta Catenin)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asian People/*genetics
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - China
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotyping Techniques
MH  - Glucagon/genetics/metabolism
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Logistic Models
MH  - Low Density Lipoprotein Receptor-Related Protein-5/genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Transcription Factor 7-Like 2 Protein/genetics/metabolism
MH  - *Wnt Signaling Pathway
MH  - Young Adult
MH  - beta Catenin/*genetics/metabolism
PMC - PMC4488812
OTO - NOTNLM
OT  - Chinese
OT  - WNT signaling pathway
OT  - polymorphisms
OT  - type 2 diabetes
EDAT- 2015/06/18 06:00
MHDA- 2016/05/04 06:00
PMCR- 2015/06/01
CRDT- 2015/06/18 06:00
PHST- 2015/03/23 00:00 [received]
PHST- 2015/05/28 00:00 [revised]
PHST- 2015/06/03 00:00 [accepted]
PHST- 2015/06/18 06:00 [entrez]
PHST- 2015/06/18 06:00 [pubmed]
PHST- 2016/05/04 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - nu7064763 [pii]
AID - nutrients-07-04763 [pii]
AID - 10.3390/nu7064763 [doi]
PST - epublish
SO  - Nutrients. 2015 Jun 15;7(6):4763-77. doi: 10.3390/nu7064763.