PMID- 26084349 OWN - NLM STAT- MEDLINE DCOM- 20170110 LR - 20170111 IS - 1477-0970 (Electronic) IS - 1352-4585 (Linking) VI - 22 IP - 2 DP - 2016 Feb TI - Cerebrospinal fluid amounts of HLA-G in dimeric form are strongly associated to patients with MRI inactive multiple sclerosis. PG - 245-9 LID - 10.1177/1352458515590647 [doi] AB - BACKGROUND: The relevance of human leukocyte antigen (HLA)-G in dimeric form in multiple sclerosis (MS) is still unknown. OBJECTIVE: To investigate the contribution of cerebrospinal fluid (CSF) HLA-G dimers in MS pathogenesis. METHODS: CSF amounts of 78-kDa HLA-G dimers were measured by western blot analysis in 80 MS relapsing-remitting MS (RRMS) patients and in 81 inflammatory and 70 non-inflammatory controls. RESULTS: CSF amounts of 78 kDa HLA-G dimers were more frequent in RRMS than in inflammatory (p<0.01) and non-inflammatory controls (p<0.001) and in magnetic resonance imaging (MRI) inactive than in MRI active RRMS (p<0.00001). CONCLUSION: Our findings suggest that HLA-G dimers may be implicated in termination of inflammatory response occurring in MS. CI - (c) The Author(s), 2015. FAU - Fainardi, Enrico AU - Fainardi E AD - Department of Neurosciences and Rehabilitation, Neuroradilogy Unit, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, Ferrara, Italy henryfai@tin.it. FAU - Bortolotti, Daria AU - Bortolotti D AD - Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy. FAU - Bolzani, Silvia AU - Bolzani S AD - Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy. FAU - Castellazzi, Massimiliano AU - Castellazzi M AD - Department of Biomedical and Specialist Surgical Sciences, Section of Neurology, University of Ferrara, Ferrara, Italy. FAU - Tamborino, Carmine AU - Tamborino C AD - Department of Biomedical and Specialist Surgical Sciences, Section of Neurology, University of Ferrara, Ferrara, Italy. FAU - Roversi, Gloria AU - Roversi G AD - Department of Biomedical and Specialist Surgical Sciences, Section of Neurology, University of Ferrara, Ferrara, Italy. FAU - Baldi, Eleonora AU - Baldi E AD - Department of Neurosciences and Rehabilitation, Neurology Unit, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, Ferrara, Italy. FAU - Caniatti, Maria Luisa AU - Caniatti ML AD - Department of Neurosciences and Rehabilitation, Neurology Unit, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna, Ferrara, Italy. FAU - Casetta, Ilaria AU - Casetta I AD - Department of Biomedical and Specialist Surgical Sciences, Section of Neurology, University of Ferrara, Ferrara, Italy. FAU - Gentili, Valentina AU - Gentili V AD - Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy. FAU - Granieri, Enrico AU - Granieri E AD - Department of Biomedical and Specialist Surgical Sciences, Section of Neurology, University of Ferrara, Ferrara, Italy. FAU - Rizzo, Roberta AU - Rizzo R AD - Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy. CN - ERMES study group LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150617 PL - England TA - Mult Scler JT - Multiple sclerosis (Houndmills, Basingstoke, England) JID - 9509185 RN - 0 (HLA-G Antigens) SB - IM MH - Adult MH - Blotting, Western MH - Brain/*pathology MH - Case-Control Studies MH - Dimerization MH - Female MH - HLA-G Antigens/*cerebrospinal fluid MH - Humans MH - Inflammation/cerebrospinal fluid MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Multiple Sclerosis, Relapsing-Remitting/*cerebrospinal fluid/pathology MH - Nervous System Diseases/cerebrospinal fluid MH - Spinal Cord/*pathology OTO - NOTNLM OT - CSF levels OT - HLA-G OT - MRI activity OT - Multiple Sclerosis OT - dimeric form FIR - Granieri, E IR - Granieri E FIR - Castellazzi, M IR - Castellazzi M FIR - Casetta, I IR - Casetta I FIR - Tola, Mr IR - Tola M FIR - Fainardi, E IR - Fainardi E FIR - Dallocchio, F IR - Dallocchio F FIR - Bellini, T IR - Bellini T FIR - Rizzo, R IR - Rizzo R FIR - Rotola, A IR - Rotola A FIR - Di Luca, D IR - Di Luca D FIR - Seraceni, S IR - Seraceni S FIR - Contini, C IR - Contini C FIR - Sabbioni, S IR - Sabbioni S FIR - Negrini, M IR - Negrini M FIR - Tognon, M IR - Tognon M FIR - Antonelli, T IR - Antonelli T FIR - Groppo, E IR - Groppo E FIR - Gentile, M IR - Gentile M FIR - Baldi, E IR - Baldi E FIR - Caniatti, Ml IR - Caniatti M FIR - Ceruti, S IR - Ceruti S FIR - Manfrinato, Mr IR - Manfrinato M FIR - Trentini, A IR - Trentini A FIR - Bortolotti, D IR - Bortolotti D FIR - Miotto, E IR - Miotto E FIR - Ferracin, M IR - Ferracin M FIR - Mazzoni, E IR - Mazzoni E FIR - Pietrobon, S IR - Pietrobon S FIR - Masini, I IR - Masini I FIR - Rotondo, Jc IR - Rotondo J FIR - Martini, F IR - Martini F FIR - Baruzzi, A IR - Baruzzi A FIR - Roberto D'Alessandro, R IR - Roberto D'Alessandro R FIR - Michelucci, R IR - Michelucci R FIR - Salvi, F IR - Salvi F FIR - Stecchi, S IR - Stecchi S FIR - Scandellari, C IR - Scandellari C FIR - Terzano, G IR - Terzano G FIR - Granella, F IR - Granella F FIR - Nichelli, P IR - Nichelli P FIR - Sola, P IR - Sola P FIR - Ferraro, D IR - Ferraro D FIR - Vitetta, F IR - Vitetta F FIR - Simone, Am IR - Simone A FIR - Bedin, R IR - Bedin R FIR - Marcello, N IR - Marcello N FIR - Motti, L IR - Motti L FIR - Montepietra, S IR - Montepietra S FIR - Guidetti, D IR - Guidetti D FIR - Immovilli, P IR - Immovilli P FIR - Montanari, E IR - Montanari E FIR - Pesci, I IR - Pesci I FIR - Guareschi, A IR - Guareschi A FIR - Greco, G IR - Greco G FIR - Santangelo, M IR - Santangelo M FIR - Mauro, Am IR - Mauro A FIR - Malagu, S IR - Malagu S FIR - Rasi, F IR - Rasi F FIR - Spadoni, M IR - Spadoni M FIR - Galeotti, M IR - Galeotti M FIR - Fiorani, L IR - Fiorani L FIR - Neri, W IR - Neri W FIR - Ravasio, A IR - Ravasio A FIR - Pasquinelli, M IR - Pasquinelli M FIR - Gutman, S IR - Gutman S FIR - Monaldini, C IR - Monaldini C EDAT- 2015/06/19 06:00 MHDA- 2017/01/11 06:00 CRDT- 2015/06/19 06:00 PHST- 2015/01/27 00:00 [received] PHST- 2015/05/13 00:00 [accepted] PHST- 2015/06/19 06:00 [entrez] PHST- 2015/06/19 06:00 [pubmed] PHST- 2017/01/11 06:00 [medline] AID - 1352458515590647 [pii] AID - 10.1177/1352458515590647 [doi] PST - ppublish SO - Mult Scler. 2016 Feb;22(2):245-9. doi: 10.1177/1352458515590647. Epub 2015 Jun 17.