PMID- 26086000
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150618
LR  - 20200930
IS  - 2222-3959 (Print)
IS  - 2227-4898 (Electronic)
IS  - 2222-3959 (Linking)
VI  - 8
IP  - 3
DP  - 2015
TI  - Focal choroidal excavation: a preliminary interpretation based on clinic and 
      review.
PG  - 513-21
LID - 10.3980/j.issn.2222-3959.2015.03.14 [doi]
AB  - AIM: To describe the clinical and imaging characteristics associated with focal 
      choroidal excavation (FCE), analyze the possible complication, and interpret its 
      probable etiopathogenesis. METHODS: Retrospective descriptive case series of 37 
      eyes of 32 patients with FCE. Findings of spectral-domain optical coherence 
      tomography (SD-OCT), fluorescein angiography, indocyanine green angiography, and 
      clinical features were analyzed. RESULTS: All patients were Chinese. Five 
      patients (15.6%) were bilaterally involved. Patients' ages ranged from 7 to 66y. 
      Refractive error ranged between +2.0 D and -11.0 D. Mean best-corrected visual 
      acuity was 0.6 (range, 0.1 to 1.2). Fundus examinations exhibited mild-moderate 
      localized pigmentary disturbances in the corresponding area of 17 eyes. 
      Fluorescein angiography performed in 18 patients showed varying degrees of 
      hyperfluorescence and hypofluorescence related to a range of retinal pigment 
      epithelium (RPE) alterations. Indocyanine green angiography performed in 7 
      patients showed hypofluorescence at the excavation. SD-OCT demonstrated choroidal 
      excavation in all 37 eyes. Twenty-nine eyes showed a single lesion of FCE, and 
      three eyes showed 2-3 separated lesions. Fifteen eyes showed separation between 
      the photoreceptor tips and RPE consistent with nonconforming FCE. Central serous 
      chorioretinopathy (CSC, n=1) and choroidal neovascularization (CNV, n=1) 
      developed during follow-up. CONCLUSION: FCE could be interpreted as congenital 
      focal choroidal dysplasia involving the RPE, choriocapillaris, and photoreceptor 
      associated with the faulty anatomy. The abnormal anatomy of FCE was similar to 
      anatomy at risk of CSC and CNV.
FAU - Liu, Guang-Hui
AU  - Liu GH
AD  - School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical 
      University, Wenzhou 325000, Zhejiang Province, China ; Department of 
      Ophthalmology, Affiliated People's Hospital to Fujian University of Traditional 
      Chinese Medicine, Fuzhou 350004, Fujian Province, China.
FAU - Lin, Bing
AU  - Lin B
AD  - School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical 
      University, Wenzhou 325000, Zhejiang Province, China.
FAU - Sun, Xin-Quan
AU  - Sun XQ
AD  - Department of Ophthalmology, China-Japan Friendship Hospital, Beijing 100029, 
      China.
FAU - He, Zi-Fang
AU  - He ZF
AD  - School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical 
      University, Wenzhou 325000, Zhejiang Province, China.
FAU - Li, Ji-Rong
AU  - Li JR
AD  - School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical 
      University, Wenzhou 325000, Zhejiang Province, China.
FAU - Zhou, Rong
AU  - Zhou R
AD  - School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical 
      University, Wenzhou 325000, Zhejiang Province, China.
FAU - Liu, Xiao-Ling
AU  - Liu XL
AD  - School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical 
      University, Wenzhou 325000, Zhejiang Province, China.
LA  - eng
PT  - Journal Article
DEP - 20150618
PL  - China
TA  - Int J Ophthalmol
JT  - International journal of ophthalmology
JID - 101553860
PMC - PMC4458655
OTO - NOTNLM
OT  - dysplasia
OT  - etiology
OT  - focal choroidal excavation
OT  - optical coherence tomography
EDAT- 2015/06/19 06:00
MHDA- 2015/06/19 06:01
PMCR- 2015/06/18
CRDT- 2015/06/19 06:00
PHST- 2014/06/10 00:00 [received]
PHST- 2014/11/18 00:00 [accepted]
PHST- 2015/06/19 06:00 [entrez]
PHST- 2015/06/19 06:00 [pubmed]
PHST- 2015/06/19 06:01 [medline]
PHST- 2015/06/18 00:00 [pmc-release]
AID - ijo-08-03-513 [pii]
AID - 10.3980/j.issn.2222-3959.2015.03.14 [doi]
PST - epublish
SO  - Int J Ophthalmol. 2015 Jun 18;8(3):513-21. doi: 
      10.3980/j.issn.2222-3959.2015.03.14. eCollection 2015.