PMID- 26086992
OWN - NLM
STAT- MEDLINE
DCOM- 20160411
LR  - 20150708
IS  - 1939-6376 (Electronic)
IS  - 1939-6368 (Linking)
VI  - 61
IP  - 4
DP  - 2015
TI  - Six polymorphisms in genes involved in DNA double-strand break repair and 
      chromosome synapsis: association with male infertility.
PG  - 187-93
LID - 10.3109/19396368.2015.1027014 [doi]
AB  - Four genes involved in DNA double-strand break repair and chromosome synapsis, 
      i.e., testis expressed gene 11 (TEX11), testis expressed gene 15 (TEX15), mutL 
      homolog 1 (MLH1), and homolog 3 (MLH3), play critical roles in genome integrity, 
      meiotic recombination, and gametogenesis. We explored the possible association 
      between single nucleotide polymorphisms (SNPs) in these genes and idiopathic male 
      infertility involving azoospermia or oligozoospermia. A total of 614 fertile 
      control and infertile men were recruited to this study in Sichuan, China. The 
      latter group included 244 men with azoospermia and 72 men with oligozoospermia. 
      Six SNPs in the TEX11, TEX15, MLH1, and MLH3 genes were investigated in both 
      patients and controls by sequencing. The frequency distributions of SNPs 
      rs6525433, rs175080, rs6525433-rs4844247, and rs1800734-rs175080 were found to be 
      significantly different between patients and control groups (p < 0.05), while 
      rs4844247, rs323344, rs323346, and rs1800734 showed no significant difference 
      between the two cohorts. Thus, the SNPs TEX11 rs6525433, MLH3 rs175080, 
      rs6525433-rs4844247, and rs1800734-rs175080 might be associated with male 
      infertility.
FAU - Zhang, Xiaohui
AU  - Zhang X
AD  - Institute of Medical Genetics, College of Life Science, Sichuan University , 
      Chengdu , China .
FAU - Ding, Min
AU  - Ding M
FAU - Ding, Xianping
AU  - Ding X
FAU - Li, Tianjun
AU  - Li T
FAU - Chen, Honghan
AU  - Chen H
LA  - eng
PT  - Journal Article
DEP - 20150618
PL  - England
TA  - Syst Biol Reprod Med
JT  - Systems biology in reproductive medicine
JID - 101464963
SB  - IM
MH  - *Chromosome Pairing
MH  - *DNA Damage
MH  - *DNA Repair
MH  - Humans
MH  - Infertility, Male/*genetics
MH  - Male
MH  - *Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Chromosome synapsis
OT  - DSB repair
OT  - SNPs
OT  - male infertility
EDAT- 2015/06/19 06:00
MHDA- 2016/04/12 06:00
CRDT- 2015/06/19 06:00
PHST- 2015/06/19 06:00 [entrez]
PHST- 2015/06/19 06:00 [pubmed]
PHST- 2016/04/12 06:00 [medline]
AID - 10.3109/19396368.2015.1027014 [doi]
PST - ppublish
SO  - Syst Biol Reprod Med. 2015;61(4):187-93. doi: 10.3109/19396368.2015.1027014. Epub 
      2015 Jun 18.