PMID- 26087128
OWN - NLM
STAT- MEDLINE
DCOM- 20160427
LR  - 20231104
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 6
DP  - 2015
TI  - Association between Body Mass Index and Health-Related Quality of Life: The 
      "Obesity Paradox" in 21,218 Adults of the Chinese General Population.
PG  - e0130613
LID - 10.1371/journal.pone.0130613 [doi]
LID - e0130613
AB  - BACKGROUND: There was no consistent recognition of the association between high 
      or low body mass index (BMI) and health related quality of life (HRQL). The aim 
      of this research was to study the association between BMI and HRQL in Chinese 
      adults, and to further explore the stability of that association in the subgroup 
      analysis stratified by status of chronic conditions. METHODS: A total of 21,218 
      adults aged 18 and older were classified as underweight, normal weight, 
      overweight, class I obese, and class II obese based on their BMI. HRQL was 
      measured by the SF-36 Health Survey. The independent impact of each BMI category 
      on HRQL was examined through standard least squares regression by comparing the 
      difference of SF-36 scores and the minimum clinically important differences 
      (MCID), which was defined as 3 points. RESULTS: Compared to the normal weight, 
      the class I obese was significantly associated with better HRQL scores in the 
      mental component summary (MCS) (75.1 vs. 73.4, P<0.001). The underweight had the 
      lowest score in both the physical components summary (PCS) (75.4 vs. 77.5, 
      P<0.001) and mental components summary (MCS) (71.8 vs. 73.4, P<0.001). For the 
      MCID, the HRQL score was reduced by more than 3 points in the physical 
      functioning for the class II obese (D=-3.43) and the general health for the 
      underweight (D=-3.71). Stratified analyses showed a similar result in the health 
      subjects and chronic conditions, and it was significant in the chronic 
      conditions. CONCLUSIONS: The class I obese showed the best HRQL, especially in 
      the mental domain. The worst HRQL was found in the underweight. The class II 
      obese reduced HRQL in the physical functioning only. "Obesity paradox" was more 
      obvious in the participants with chronic conditions.
FAU - Zhu, Yanbo
AU  - Zhu Y
AD  - School of Management, Beijing University of Chinese Medicine, Beijing, China.
FAU - Wang, Qi
AU  - Wang Q
AD  - School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing, 
      China.
FAU - Pang, Guoming
AU  - Pang G
AD  - Internal Medicine Department, Kaifeng Hospital of Traditional Chinese Medicine, 
      Kaifeng, Henan, China.
FAU - Lin, Lin
AU  - Lin L
AD  - Department of Quality Management, China-Japan Friendship Hospital, Beijing, 
      China.
FAU - Origasa, Hideki
AU  - Origasa H
AD  - Division of Biostatistics and Clinical Epidemiology, School of Medicine, 
      University of Toyama, Toyama, Japan.
FAU - Wang, Yangyang
AU  - Wang Y
AD  - School of Management, Beijing University of Chinese Medicine, Beijing, China.
FAU - Di, Jie
AU  - Di J
AD  - School of Management, Beijing University of Chinese Medicine, Beijing, China.
FAU - Shi, Mai
AU  - Shi M
AD  - Department of Clinical Nutrition, China-Japan Friendship Hospital, Beijing, 
      China.
FAU - Fan, Chunpok
AU  - Fan C
AD  - School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing, 
      China.
FAU - Shi, Huimei
AU  - Shi H
AD  - School of Management, Beijing University of Chinese Medicine, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150618
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Body Mass Index
MH  - China/epidemiology
MH  - Female
MH  - Health Status
MH  - Health Surveys
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/*epidemiology
MH  - Overweight/epidemiology
MH  - *Quality of Life
MH  - Thinness/epidemiology
MH  - Young Adult
PMC - PMC4472696
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/06/19 06:00
MHDA- 2016/04/28 06:00
PMCR- 2015/06/18
CRDT- 2015/06/19 06:00
PHST- 2014/06/27 00:00 [received]
PHST- 2015/05/21 00:00 [accepted]
PHST- 2015/06/19 06:00 [entrez]
PHST- 2015/06/19 06:00 [pubmed]
PHST- 2016/04/28 06:00 [medline]
PHST- 2015/06/18 00:00 [pmc-release]
AID - PONE-D-14-23204 [pii]
AID - 10.1371/journal.pone.0130613 [doi]
PST - epublish
SO  - PLoS One. 2015 Jun 18;10(6):e0130613. doi: 10.1371/journal.pone.0130613. 
      eCollection 2015.