PMID- 26087362
OWN - NLM
STAT- MEDLINE
DCOM- 20150903
LR  - 20220409
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 56
IP  - 6
DP  - 2015 Jun
TI  - Ganglion Cell-Inner Plexiform Layer and Peripapillary Retinal Nerve Fiber Layer 
      Thicknesses in Age-Related Macular Degeneration.
PG  - 3976-83
LID - 10.1167/iovs.15-17013 [doi]
AB  - PURPOSE: To investigate changes of inner retinal layers and optic nerve head 
      (ONH) in patients with dry age-related macular degeneration (AMD) and demonstrate 
      the pattern of these changes. METHODS: A total of 76 eyes classified as having 
      dry AMD and 76 control eyes were included. Ophthalmologic evaluations included 
      best-corrected visual acuity (BCVA) assessment, spectral-domain optical coherence 
      tomography (SD-OCT), and Humphrey visual field (VF) test. The drusen area and 
      volume were determined using the automated algorithm of the SD-OCT software. 
      Macular ganglion cell-inner plexiform layer (mGCIPL) and peripapillary retinal 
      nerve fiber layer (pRNFL) thicknesses and ONH parameters, as well as VF 
      parameters, were compared between groups. RESULTS: Macular GCIPL thickness was 
      significantly lower in eyes with AMD than in controls (73.83 +/- 7.13 vs. 82.00 +/- 
      4.85 mum; P < 0.001), and mGCIPL thinning was observed in a ring-shaped pattern 
      around the fovea. The pRNFL thickness was also significantly lower in eyes with 
      AMD than in controls (88.69 +/- 6.93 vs. 93.96 +/- 8.33 mum; P < 0.001), but no 
      significant difference in ONH parameters was found. An inverse correlation 
      between drusen area and average mGCIPL thickness was found (r = -0.3253; P = 
      0.0064). Best-corrected visual acuity and VF parameters were worse in AMD eyes 
      than in controls. The pattern of VF defects was mostly consistent with foveal or 
      parafoveal scotoma. CONCLUSIONS: In eyes with dry AMD, mGCIPL and pRNFL 
      thicknesses were lower than measurements in control eyes, and the average mGCIPL 
      thickness was negatively correlated with the drusen area. However, the pattern of 
      these changes differed from glaucomatous abnormalities.
FAU - Lee, Eun Kyoung
AU  - Lee EK
AD  - Department of Ophthalmology Seoul National University College of Medicine, Seoul 
      National University Hospital, Seoul, Korea
FAU - Yu, Hyeong Gon
AU  - Yu HG
AD  - Department of Ophthalmology Seoul National University College of Medicine, Seoul 
      National University Hospital, Seoul, Korea
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Macular Degeneration/*pathology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Optic Disk/pathology
MH  - Regression Analysis
MH  - Retinal Drusen/pathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/methods
MH  - Visual Acuity/physiology
MH  - Visual Fields
EDAT- 2015/06/19 06:00
MHDA- 2015/09/04 06:00
CRDT- 2015/06/19 06:00
PHST- 2015/06/19 06:00 [entrez]
PHST- 2015/06/19 06:00 [pubmed]
PHST- 2015/09/04 06:00 [medline]
AID - 2337488 [pii]
AID - 10.1167/iovs.15-17013 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3976-83. doi: 10.1167/iovs.15-17013.