PMID- 26087627
OWN - NLM
STAT- MEDLINE
DCOM- 20150714
LR  - 20181023
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 87
IP  - 4
DP  - 2015
TI  - [Assessment of the role of matrix metalloproteinase-3 gene polymorphism in the 
      development of chronic heart failure].
PG  - 8-12
LID - 10.17116/terarkh20158748-12 [doi]
AB  - AIM: To study the impact of a polymorphic variant of the matrix 
      metalloproteinase-3 (MMP-3) gene on the development and course of chronic heart 
      failure (CHF) in patients with coronary heart disease. SUBJECTS AND METHODS: A 
      total of 277 patients with New York Heart Association (NYHA) Functional Class 
      (FC) II-IV CHF were examined. MMP-3 -1171 5A/6A genetic polymorphism was studied 
      by polymerase chain reaction. A control group included 136 patients (mean age 
      53.6 +/- 4.8 years) with no signs of cardiovascular diseases, as evidenced by the 
      examination. RESULTS: The frequency of the 5A allele and the 5A/5A genotype of 
      the 1171 5A/6A polymorphic locus in the MMP-3 gene proved to be higher in the 
      patients with CHF than that in the control group. Thus, the variability of the 5A 
      allele (odds ratio (OR), 1.39; 95% confidence interval (CI): 1.033 to 1.869; p = 
      0.03) and the 5A/5A genotype (OR, 2.15; 95% CI: 1.131 to 4.070; p = 0.02) was 
      associated with increased risk for CHF. There were significant differences in the 
      frequency of MMP-3 alleles and genotypes in relation to FC of CHF. The frequency 
      of the 5A/5A genotype was substantially higher in the patients with NYHA FC IV 
      CHF than that in those with NYHA FC II CHF (32.8% versus 15.2%; p = 0.039). The 
      frequency of the 5A allele was significantly higher in the patients with NYHA FC 
      IV CHF than that in those with NYHA FC II CHF (55.5% and 39.3%; respectively; p = 
      0.019). Thus, the carriage of the 5A allele and the 5A/5A genotype of the 1171 
      5A/6A polymorphic locus in the MMP-3 gene is a risk factor of severe CHF. 
      CONCLUSION: The determination of MMP-3 -1171 5A/6A polymorphism may be 
      recommended for the early prediction of a risk for the development and severe 
      course of CHF.
FAU - Teplyakov, A T
AU  - Teplyakov AT
AD  - Department of Heart Failure, Research Institute of Cardiology, Tomsk, Russia.
FAU - Berezikova, E N
AU  - Berezikova EN
AD  - Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, 
      Russia.
FAU - Shilov, S N
AU  - Shilov SN
AD  - Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, 
      Russia.
FAU - Grakova, E V
AU  - Grakova EV
AD  - Department of Heart Failure, Research Institute of Cardiology, Tomsk, Russia.
FAU - Torim, Yu Yu
AU  - Torim YY
AD  - Department of Heart Failure, Research Institute of Cardiology, Tomsk, Russia.
FAU - Efremov, A V
AU  - Efremov AV
AD  - Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, 
      Russia.
FAU - Safronov, I D
AU  - Safronov ID
AD  - Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, 
      Russia.
FAU - Pustovetova, M G
AU  - Pustovetova MG
AD  - Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, 
      Russia.
FAU - Karpov, R S
AU  - Karpov RS
AD  - Department of Heart Failure, Research Institute of Cardiology, Tomsk, Russia.
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
RN  - 9007-49-2 (DNA)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - DNA/*genetics
MH  - Disease Progression
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Heart Failure/enzymology/*genetics
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics/metabolism
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
EDAT- 2015/06/20 06:00
MHDA- 2015/07/15 06:00
CRDT- 2015/06/20 06:00
PHST- 2015/06/20 06:00 [entrez]
PHST- 2015/06/20 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.17116/terarkh20158748-12 [doi]
PST - ppublish
SO  - Ter Arkh. 2015;87(4):8-12. doi: 10.17116/terarkh20158748-12.