PMID- 26088029
OWN - NLM
STAT- MEDLINE
DCOM- 20160321
LR  - 20150703
IS  - 1423-0259 (Electronic)
IS  - 0030-3747 (Linking)
VI  - 54
IP  - 1
DP  - 2015
TI  - Multimodal Imaging of Cotton Wool Spots in Branch Retinal Vein Occlusion.
PG  - 48-56
LID - 10.1159/000430843 [doi]
AB  - PURPOSE: To describe and follow cotton wool spots (CWS) in branch retinal vein 
      occlusion (BRVO) using multimodal imaging. METHODS: In this prospective cohort 
      study including 24 patients with new-onset BRVO, CWS were described and analyzed 
      in color fundus photography (CF), spectral domain optical coherence tomography 
      (SD-OCT), infrared (IR) and fluorescein angiography (FA) every 3 months for 3 
      years. The CWS area on SD-OCT and CF was evaluated using OCT-Tool-Kit software: 
      CWS were marked in each single OCT B-scan and the software calculated the area by 
      interpolation. RESULTS: 29 central CWS lesions were found. 100% of these CWS were 
      visible on SD-OCT, 100% on FA and 86.2% on IR imaging, but only 65.5% on CF 
      imaging. CWS were visible for 12.4 +/- 7.5 months on SD-OCT, for 4.4 +/- 3 months and 
      4.3 +/- 3.4 months on CF and on IR, respectively, and for 17.5 +/- 7.1 months on FA. 
      The evaluated CWS area on SD-OCT was larger than on CF (0.26 +/- 0.17 mm(2) vs. 
      0.13 +/- 0.1 mm(2), p < 0.0001). The CWS area on SD-OCT and surrounding pathology 
      such as intraretinal cysts, avascular zones and intraretinal hemorrhage were 
      predictive for how long CWS remained visible (r(2) = 0.497, p < 0.002). 
      CONCLUSIONS: The lifetime and presentation of CWS in BRVO seem comparable to 
      other diseases. SD-OCT shows a higher sensitivity for detecting CWS compared to 
      CF. The duration of visibility of CWS varies among different image modalities and 
      depends on the surrounding pathology and the CWS size.
CI  - (c) 2015 S. Karger AG, Basel.
FAU - Munk, Marion R
AU  - Munk MR
AD  - Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
FAU - Matt, Gerlinde
AU  - Matt G
FAU - Baratsits, Magdalena
AU  - Baratsits M
FAU - Dunavoelgyi, Roman
AU  - Dunavoelgyi R
FAU - Huf, Wolfgang
AU  - Huf W
FAU - Montuoro, Alessio
AU  - Montuoro A
FAU - Buehl, Wolf
AU  - Buehl W
FAU - Schmidt-Erfurth, Ursula
AU  - Schmidt-Erfurth U
FAU - Sacu, Stefan
AU  - Sacu S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150612
PL  - Switzerland
TA  - Ophthalmic Res
JT  - Ophthalmic research
JID - 0267442
SB  - IM
MH  - Aged
MH  - *Diagnostic Techniques, Ophthalmological
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Multimodal Imaging
MH  - Photography/methods
MH  - Prospective Studies
MH  - Retinal Hemorrhage/pathology
MH  - Retinal Vein Occlusion/*diagnosis/pathology
MH  - Tomography, Optical Coherence/methods
EDAT- 2015/06/20 06:00
MHDA- 2016/03/22 06:00
CRDT- 2015/06/20 06:00
PHST- 2015/04/07 00:00 [received]
PHST- 2015/04/20 00:00 [accepted]
PHST- 2015/06/20 06:00 [entrez]
PHST- 2015/06/20 06:00 [pubmed]
PHST- 2016/03/22 06:00 [medline]
AID - 000430843 [pii]
AID - 10.1159/000430843 [doi]
PST - ppublish
SO  - Ophthalmic Res. 2015;54(1):48-56. doi: 10.1159/000430843. Epub 2015 Jun 12.