PMID- 26090557
OWN - NLM
STAT- MEDLINE
DCOM- 20150824
LR  - 20190111
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 78
IP  - 12
DP  - 2015
TI  - Effects of Maternal Exposure to Cadmium Oxide Nanoparticles During Pregnancy on 
      Maternal and Offspring Kidney Injury Markers Using a Murine Model.
PG  - 711-24
LID - 10.1080/15287394.2015.1026622 [doi]
AB  - Nanoparticles (NP) are pervasive in many areas of modern life, with little known 
      about their potential toxicities. One commercially important NP is cadmium oxide 
      (CdO), which is used to synthesize other Cd-containing NP, such as quantum dots. 
      Cadmium (Cd) is a well-known nephrotoxicant, but the nephrotoxic potential of CdO 
      NP remains unknown, particularly when exposure occurs during pregnancy. 
      Therefore, pregnant CD-1 mice were used to examine the effects of inhaled CdO NP 
      (230 mug CdO NP/m(3)) on maternal and neonatal renal function by examining urinary 
      creatinine and urinary biomarkers of kidney injury, including kidney injury 
      molecule-1 (Kim-1) and neutrophil gelatinase-associated lipocalin (NGAL). 
      Inhalation of CdO NP by dams produced a fivefold increase in urinary Kim-1 with 
      no marked effect on urinary creatinine levels. Kim-1 mRNA expression peaked by 
      gestational day (GD) 10.5, and NGAL expression increased from GD 10.5 to 17.5. In 
      addition, histological analyses revealed proximal tubular pathology at GD 10.5. 
      Neonatal Kim-1 mRNA expression rose between postnatal days (PND) 7 and 14, with 
      mammary glands/milk being the apparent source of Cd for offspring. These studies 
      demonstrate that, similar to what is seen with other Cd forms, Cd associated with 
      inhaled CdO NP results in renal injury to both directly exposed dam and 
      offspring. As commercial uses for nanotechnology continue to expand throughout 
      the world, risks for unintentional exposure in the workplace increase. Given the 
      large number of women in the industrial workforce, care needs to be taken to 
      protect these already vulnerable populations.
FAU - Blum, Jason L
AU  - Blum JL
AD  - a Department of Environmental Medicine , New York University School of Medicine , 
      Tuxedo , New York , USA.
FAU - Edwards, Joshua R
AU  - Edwards JR
FAU - Prozialeck, Walter C
AU  - Prozialeck WC
FAU - Xiong, Judy Q
AU  - Xiong JQ
FAU - Zelikoff, Judith T
AU  - Zelikoff JT
LA  - eng
GR  - R01 ES017427/ES/NIEHS NIH HHS/United States
GR  - R01-ES017427/ES/NIEHS NIH HHS/United States
GR  - T32-ES007324/ES/NIEHS NIH HHS/United States
GR  - T32 ES007324/ES/NIEHS NIH HHS/United States
GR  - P30 ES000260/ES/NIEHS NIH HHS/United States
GR  - ES000260/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (Cadmium Compounds)
RN  - 0 (Havcr1 protein, mouse)
RN  - 0 (Hepatitis A Virus Cellular Receptor 1)
RN  - 0 (Lipocalin-2)
RN  - 0 (Lipocalins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Oncogene Proteins)
RN  - 0 (Oxides)
RN  - 0 (RNA, Messenger)
RN  - 0H3KWS8KJ3 (cadmium oxide)
RN  - 126469-30-5 (Lcn2 protein, mouse)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Acute Kidney Injury/*chemically induced/*congenital/pathology
MH  - Acute-Phase Proteins/biosynthesis/genetics
MH  - Animals
MH  - Animals, Newborn
MH  - Biomarkers/urine
MH  - Cadmium Compounds/pharmacokinetics/*toxicity
MH  - Creatinine/urine
MH  - Female
MH  - Glycosuria/chemically induced/urine
MH  - Hepatitis A Virus Cellular Receptor 1
MH  - Inhalation Exposure
MH  - Kidney/pathology
MH  - Lipocalin-2
MH  - Lipocalins/biosynthesis/genetics
MH  - Mammary Glands, Animal/metabolism
MH  - Maternal Exposure
MH  - Membrane Proteins/biosynthesis/genetics
MH  - Mice
MH  - Nanoparticles/*toxicity
MH  - Oncogene Proteins/biosynthesis/genetics
MH  - Oxides/pharmacokinetics/*toxicity
MH  - Pregnancy
MH  - RNA, Messenger/biosynthesis
PMC - PMC4560236
MID - NIHMS718595
EDAT- 2015/06/20 06:00
MHDA- 2015/08/25 06:00
PMCR- 2016/01/01
CRDT- 2015/06/20 06:00
PHST- 2015/06/20 06:00 [entrez]
PHST- 2015/06/20 06:00 [pubmed]
PHST- 2015/08/25 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.1080/15287394.2015.1026622 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 2015;78(12):711-24. doi: 
      10.1080/15287394.2015.1026622.