PMID- 26090916
OWN - NLM
STAT- MEDLINE
DCOM- 20160525
LR  - 20150831
IS  - 1558-2035 (Electronic)
IS  - 1558-2027 (Linking)
VI  - 16
IP  - 10
DP  - 2015 Oct
TI  - Prognostic significance of myocardial extracellular volume fraction in 
      nonischaemic dilated cardiomyopathy.
PG  - 681-7
LID - 10.2459/JCM.0000000000000275 [doi]
AB  - AIMS: In nonischaemic dilated cardiomyopathy (NICM), replacement myocardial 
      fibrosis as detected by late gadolinium enhancement (LGE) at cardiovascular 
      magnetic resonance (CMR) is associated with poor prognosis. We investigated the 
      as-yet unexplored prognostic significance of interstitial fibrosis in NICM, using 
      T1-mapping CMR. METHODS: Eighty-nine NICM patients (63 men, age 59 +/- 14 years) 
      with left ventricular systolic dysfunction (ejection fraction 41 +/- 13%) underwent 
      comprehensive clinical and CMR evaluation, with extracellular volume fraction 
      (ECV) estimation from pre and postcontrast T1 mapping. Fifteen healthy 
      individuals (11 men, mean age 52 +/- 11 years) were used as controls. The end-point 
      was a composite of cardiovascular death, hospitalization for heart failure and 
      appropriate defibrillator intervention. RESULTS: Myocardial ECV was higher in 
      NICM patients (0.31 +/- 0.05) than controls (0.25 +/- 0.04, P < 0.01). In NICM 
      patients, myocardial ECV correlated with left ventricular ejection fraction 
      (R = 0.13), LGE extent (R = 0.17), Doppler E/E' (R = 0.17) and ventricular 
      tachycardias (R = 0.21) at 24-h ECG monitoring (P < 0.05 for all). During a 
      median follow-up of 24 months (interquartile range 12-42 months), 12 events 
      occurred and higher myocardium ECV was independently associated with the 
      occurrence of the composite end-point (P < 0.01). CONCLUSION: In NICM patients, 
      myocardial ECV was increased compared with normal individuals, likely reflecting 
      extracellular matrix remodelling and collagen deposition, and resulted an 
      independent prognostic predictor beyond all other conventional clinical, 
      electrocardiographic and echocardiographic parameters.
FAU - Barison, Andrea
AU  - Barison A
AD  - aFondazione Toscana Gabriele Monasterio bScuola Superiore Sant'Anna, Pisa 
      cI.R.C.C.S Policlinico San Donato, San Donato, Milanese, Italy dBiomedical 
      Sciences, Katholieke Universiteit, Leuven, Belgium.
FAU - Del Torto, Alberico
AU  - Del Torto A
FAU - Chiappino, Sara
AU  - Chiappino S
FAU - Aquaro, Giovanni Donato
AU  - Aquaro GD
FAU - Todiere, Giancarlo
AU  - Todiere G
FAU - Vergaro, Giuseppe
AU  - Vergaro G
FAU - Passino, Claudio
AU  - Passino C
FAU - Lombardi, Massimo
AU  - Lombardi M
FAU - Emdin, Michele
AU  - Emdin M
FAU - Masci, Pier Giorgio
AU  - Masci PG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cardiovasc Med (Hagerstown)
JT  - Journal of cardiovascular medicine (Hagerstown, Md.)
JID - 101259752
RN  - 0 (Contrast Media)
SB  - IM
CIN - J Cardiovasc Med (Hagerstown). 2016 Mar;17(3):226-7. PMID: 26825332
CIN - J Cardiovasc Med (Hagerstown). 2016 Mar;17(3):227. PMID: 26825333
MH  - Adult
MH  - Aged
MH  - Cardiomyopathies/*physiopathology
MH  - Cardiomyopathy, Dilated/*physiopathology
MH  - Case-Control Studies
MH  - Contrast Media
MH  - Echocardiography
MH  - Female
MH  - Heart Failure/*physiopathology
MH  - Humans
MH  - Linear Models
MH  - Magnetic Resonance Imaging, Cine/methods
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prognosis
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Stroke Volume/*physiology
MH  - Survival Analysis
MH  - Ventricular Dysfunction, Left/*physiopathology
EDAT- 2015/06/20 06:00
MHDA- 2016/05/26 06:00
CRDT- 2015/06/20 06:00
PHST- 2015/06/20 06:00 [entrez]
PHST- 2015/06/20 06:00 [pubmed]
PHST- 2016/05/26 06:00 [medline]
AID - 10.2459/JCM.0000000000000275 [doi]
PST - ppublish
SO  - J Cardiovasc Med (Hagerstown). 2015 Oct;16(10):681-7. doi: 
      10.2459/JCM.0000000000000275.