PMID- 26091451
OWN - NLM
STAT- MEDLINE
DCOM- 20150914
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 94
IP  - 24
DP  - 2015 Jun
TI  - Sublingual Immunotherapy for Asthmatic Children Sensitized to House Dust Mite: A 
      Meta-Analysis.
PG  - e701
LID - 10.1097/MD.0000000000000701 [doi]
LID - e701
AB  - The house dust mite is one of the most common allergens worldwide. There is good 
      evidence that house dust mite subcutaneous immunotherapy is efficacious and has 
      long-term benefit in children. However, the evidence of the benefit of house dust 
      mite sublingual immunotherapy (SLIT) is less convincing. The purpose of this 
      meta-analysis was to evaluate that efficacy and safety of dust mite SLIT in 
      children with asthma. Medical Literature Analysis and Retrieval System Online, 
      ISI Web of Knowledge, and Cochrane Central Register of Controlled Trials 
      databases until February 2014 were searched. The primary outcome was mean change 
      in asthma symptom score. Secondary outcomes included mean change in serum 
      immunoglobulin G4 (sIgG4), specific Dermatophagoides pteronyssinus, 
      immunoglobulin E (IgE) levels, and medication score. Safety was also assessed. We 
      found that SLIT significantly decreased asthma symptom score (P = 0.007) and 
      increased sIgG4 levels (P = 0.011) greater than control in children (<18 years of 
      age) with asthma. There was no difference between SLIT and control groups in 
      specific D pteronyssinus IgE levels (P = 0.076) and medication score (P = 0.408). 
      The safety profile was similar between groups. Our study indicates that dust mite 
      SLIT therapy was effective in reducing asthma symptoms and in increasing sIgG4 
      but did not significantly reduce medication scores or specific D pteronyssinus 
      IgE levels. Our findings are not enough to support the use of dust mite SLIT in 
      children with asthma.
FAU - Liao, Wei
AU  - Liao W
AD  - Department of Pediatrics, Southwest Hospital, Third Military Medical University, 
      Chongqing, China.
FAU - Hu, Qi
AU  - Hu Q
FAU - Shen, Lei-Lei
AU  - Shen LL
FAU - Hu, Ying
AU  - Hu Y
FAU - Tao, Hai-Feng
AU  - Tao HF
FAU - Li, Hui-Fan
AU  - Li HF
FAU - Fan, Wen-Ting
AU  - Fan WT
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Asthma/*immunology/therapy
MH  - Dermatophagoides pteronyssinus
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Immunoglobulin G/blood
MH  - Male
MH  - Patient Acuity
MH  - Pyroglyphidae/*immunology
MH  - Sublingual Immunotherapy/adverse effects/*methods
PMC - PMC4616527
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2015/06/20 06:00
MHDA- 2015/09/15 06:00
PMCR- 2015/06/19
CRDT- 2015/06/20 06:00
PHST- 2015/06/20 06:00 [entrez]
PHST- 2015/06/20 06:00 [pubmed]
PHST- 2015/09/15 06:00 [medline]
PHST- 2015/06/19 00:00 [pmc-release]
AID - 00005792-201506030-00004 [pii]
AID - 10.1097/MD.0000000000000701 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2015 Jun;94(24):e701. doi: 10.1097/MD.0000000000000701.