PMID- 26093344
OWN - NLM
STAT- MEDLINE
DCOM- 20160408
LR  - 20191210
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 63
DP  - 2015 Dec 3
TI  - Long-term effects of repeated social stress on the conditioned place preference 
      induced by MDMA in mice.
PG  - 98-109
LID - S0278-5846(15)00133-5 [pii]
LID - 10.1016/j.pnpbp.2015.06.006 [doi]
AB  - Previous studies have demonstrated that social defeat stress increases the 
      rewarding effects of psychostimulant drugs such as cocaine and amphetamine. In 
      the present study we evaluated the long-term effects of repeated social defeat 
      (RSD) on the rewarding effects of +/-3,4-methylenedioxymethamphetamine (MDMA) 
      hydrochloride in the conditioned place preference (CPP) paradigm. Adolescent and 
      young adult mice were exposed to four episodes of social defeat (on PND 29-40 and 
      PND 47-56, respectively) and were conditioned three weeks later with 1.25 or 
      10mg/kg i.p. of MDMA (experiment 1). The long-term effects of RSD on anxiety, 
      social behavior and cognitive processes were also evaluated in adult mice 
      (experiment 2). RSD during adolescence enhanced vulnerability to priming-induced 
      reinstatement in animals conditioned with 1.25mg/kg of MDMA and increased the 
      duration of the CPP induced by the 10mg/kg of MDMA. The latter effect was also 
      observed after RSD in young adult mice, as well as an increase in anxiety-like 
      behavior, an alteration in social interaction (reduction in attack and increase 
      in avoidance/flee and defensive/submissive behaviors) and an impairment of maze 
      learning. These results support the idea that RSD stress increases the rewarding 
      effects of MDMA and induces long-term alterations in anxiety, learning and social 
      behavior in adult mice. Thus, exposure to stress may increase the vulnerability 
      of individuals to developing MDMA dependence, which is a factor to be taken into 
      account in relation to the prevention and treatment of this disorder.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Garcia-Pardo, M P
AU  - Garcia-Pardo MP
AD  - Unidad de Investigacion Psicobiologia de las Drogodependencias, Departamento de 
      Psicobiologia, Facultad de Psicologia, Universidad de Valencia, Spain.
FAU - Blanco-Gandia, M C
AU  - Blanco-Gandia MC
AD  - Unidad de Investigacion Psicobiologia de las Drogodependencias, Departamento de 
      Psicobiologia, Facultad de Psicologia, Universidad de Valencia, Spain.
FAU - Valiente-Lluch, M
AU  - Valiente-Lluch M
AD  - Unidad de Investigacion Psicobiologia de las Drogodependencias, Departamento de 
      Psicobiologia, Facultad de Psicologia, Universidad de Valencia, Spain.
FAU - Rodriguez-Arias, M
AU  - Rodriguez-Arias M
AD  - Unidad de Investigacion Psicobiologia de las Drogodependencias, Departamento de 
      Psicobiologia, Facultad de Psicologia, Universidad de Valencia, Spain.
FAU - Minarro, J
AU  - Minarro J
AD  - Unidad de Investigacion Psicobiologia de las Drogodependencias, Departamento de 
      Psicobiologia, Facultad de Psicologia, Universidad de Valencia, Spain.
FAU - Aguilar, M A
AU  - Aguilar MA
AD  - Unidad de Investigacion Psicobiologia de las Drogodependencias, Departamento de 
      Psicobiologia, Facultad de Psicologia, Universidad de Valencia, Spain. Electronic 
      address: asuncion.aguilar@uv.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150618
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenal Cortex Hormones/blood
MH  - Age Factors
MH  - Analysis of Variance
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Conditioning, Operant/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Extinction, Psychological/drug effects
MH  - Hallucinogens/*pharmacology
MH  - Interpersonal Relations
MH  - Male
MH  - Maze Learning/drug effects
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Reinforcement, Psychology
MH  - Stress, Psychological/*physiopathology/psychology
OTO - NOTNLM
OT  - Adolescence
OT  - Conditioned place preference
OT  - MDMA
OT  - Mice
OT  - Repeated social defeat
EDAT- 2015/06/21 06:00
MHDA- 2016/04/09 06:00
CRDT- 2015/06/21 06:00
PHST- 2015/03/15 00:00 [received]
PHST- 2015/05/26 00:00 [revised]
PHST- 2015/06/09 00:00 [accepted]
PHST- 2015/06/21 06:00 [entrez]
PHST- 2015/06/21 06:00 [pubmed]
PHST- 2016/04/09 06:00 [medline]
AID - S0278-5846(15)00133-5 [pii]
AID - 10.1016/j.pnpbp.2015.06.006 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2015 Dec 3;63:98-109. doi: 
      10.1016/j.pnpbp.2015.06.006. Epub 2015 Jun 18.