PMID- 26093839 OWN - NLM STAT- MEDLINE DCOM- 20160421 LR - 20150622 IS - 1969-6213 (Electronic) IS - 1774-024X (Linking) VI - 11 IP - 2 DP - 2015 Jun TI - Myocardial injury following transcatheter aortic valve implantation: insights from delayed-enhancement cardiovascular magnetic resonance. PG - 205-13 LID - EIJV11I2A39 [pii] LID - 10.4244/EIJV11I2A39 [doi] AB - AIMS: The aim of this study was to evaluate the presence, localisation and extent of myocardial injury as determined by late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) imaging in patients undergoing transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS: A total of 37 patients, who underwent successful TAVI with a balloon-expandable valve (transapical [TA], n=11; non-TA, n=26), were included. Cardiac biomarker (CK-MB and cTnT) levels were determined at baseline and following TAVI. CMR was performed within a week before and within 30 days following TAVI. Some increase in cardiac biomarkers was detected in 97% of the patients as determined by a rise in cTnT, and in 49% of the patients as determined by a rise in CK-MB. Following TAVI, no new myocardial necrosis defects were observed with the non-TA approach. Nonetheless, all patients who underwent TAVI through the TA approach had new focal myocardial necrosis in the apex, with a median myocardial extent and necrotic mass of 5% [2.0-7.0] and 3.5 g [2.3-4.5], respectively. CONCLUSIONS: Although some increase in cardiac biomarkers of myocardial injury was systematically detected following TAVI, new myocardial necrosis as evaluated by CMR was observed only in patients undergoing the procedure through the TA approach, involving ~5% of the myocardium in the apex. FAU - Ribeiro, Henrique B AU - Ribeiro HB AD - Quebec Heart & Lung Institute, Laval University, Quebec City, Quebec, Canada. FAU - Larose, Eric AU - Larose E FAU - de la Paz Ricapito, Maria AU - de la Paz Ricapito M FAU - Le Ven, Florent AU - Le Ven F FAU - Nombela-Franco, Luis AU - Nombela-Franco L FAU - Urena, Marina AU - Urena M FAU - Allende, Ricardo AU - Allende R FAU - Amat-Santos, Ignacio AU - Amat-Santos I FAU - Dahou, Abdellaziz AU - Dahou A FAU - Capoulade, Romain AU - Capoulade R FAU - Clavel, Marie-Annick AU - Clavel MA FAU - Mohammadi, Siamak AU - Mohammadi S FAU - Paradis, Jean-Michel AU - Paradis JM FAU - De Larochelliere, Robert AU - De Larochelliere R FAU - Doyle, Daniel AU - Doyle D FAU - Dumont, Eric AU - Dumont E FAU - Pibarot, Philippe AU - Pibarot P FAU - Rodes-Cabau, Josep AU - Rodes-Cabau J LA - eng GR - Canadian Institutes of Health Research/Canada PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - France TA - EuroIntervention JT - EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology JID - 101251040 SB - IM CIN - EuroIntervention. 2015 Jun;11(2):137-9. PMID: 26093836 MH - Aged MH - Aged, 80 and over MH - Aortic Valve Stenosis/*surgery MH - Cardiac Catheterization/methods MH - Female MH - Heart MH - Heart Injuries/*pathology MH - Heart Valve Prosthesis MH - Heart Valve Prosthesis Implantation/methods MH - Humans MH - *Magnetic Resonance Imaging/methods MH - Male MH - *Transcatheter Aortic Valve Replacement/methods MH - Treatment Outcome EDAT- 2015/06/22 06:00 MHDA- 2016/04/22 06:00 CRDT- 2015/06/22 06:00 PHST- 2015/06/22 06:00 [entrez] PHST- 2015/06/22 06:00 [pubmed] PHST- 2016/04/22 06:00 [medline] AID - EIJV11I2A39 [pii] AID - 10.4244/EIJV11I2A39 [doi] PST - ppublish SO - EuroIntervention. 2015 Jun;11(2):205-13. doi: 10.4244/EIJV11I2A39.