PMID- 26093946
OWN - NLM
STAT- MEDLINE
DCOM- 20160502
LR  - 20181113
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 166
IP  - 1-3
DP  - 2015 Aug
TI  - Negative symptoms in youths with psychosis spectrum features: complementary 
      scales in relation to neurocognitive performance and function.
PG  - 322-7
LID - S0920-9964(15)00310-2 [pii]
LID - 10.1016/j.schres.2015.05.037 [doi]
AB  - BACKGROUND: Negative symptoms in schizophrenia are related to impaired 
      functioning. The presence of negative symptoms in early phases of psychosis in 
      individuals at clinical risk is receiving increased attention. METHODS: We 
      evaluated comprehensively a sample of 92 young people (age range 15-25) applying 
      the Clinical Assessment Interview for Negative Symptoms (CAINS), adapted for 
      youth. Individuals at clinical high risk (CHR, n=29) were compared to individuals 
      with schizophrenia (SZ, n=31) and normal controls (NC, n=32). In addition to the 
      CAINS, participants were assessed with the Structured Interview for Prodromal 
      Syndromes (SIPS), enabling examination of the relations among scales, as well as 
      the Penn Computerized Neurocognitive Battery (CNB), to examine association with 
      cognitive performance, and the Global Assessment of Function (GAF) to assess 
      overall functioning. RESULTS: The CHR group was intermediate to SZ and NC on 
      nearly all clinical measures. Negative symptoms on the CAINS correlated better 
      with negative than with other symptoms on the SIPS and were associated with 
      neurocognitive deficits and poorer functioning. CONCLUSIONS: This study 
      illustrates the feasibility of in-depth evaluation of negative symptoms in youth 
      and indicates that these symptoms are present already in the at-risk state and 
      relate to impaired cognition and functioning.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Gur, Raquel E
AU  - Gur RE
AD  - Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, 
      University of Pennsylvania, 10 Gates, 3400 Spruce Street, Philadelphia, PA 19104, 
      USA. Electronic address: raquel@upenn.edu.
FAU - March, Mary
AU  - March M
AD  - Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, 
      University of Pennsylvania, 10 Gates, 3400 Spruce Street, Philadelphia, PA 19104, 
      USA.
FAU - Calkins, Monica E
AU  - Calkins ME
AD  - Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, 
      University of Pennsylvania, 10 Gates, 3400 Spruce Street, Philadelphia, PA 19104, 
      USA.
FAU - Weittenhiller, Lauren
AU  - Weittenhiller L
AD  - Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, 
      University of Pennsylvania, 10 Gates, 3400 Spruce Street, Philadelphia, PA 19104, 
      USA.
FAU - Wolf, Daniel H
AU  - Wolf DH
AD  - Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, 
      University of Pennsylvania, 10 Gates, 3400 Spruce Street, Philadelphia, PA 19104, 
      USA.
FAU - Turetsky, Bruce I
AU  - Turetsky BI
AD  - Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, 
      University of Pennsylvania, 10 Gates, 3400 Spruce Street, Philadelphia, PA 19104, 
      USA.
FAU - Gur, Ruben C
AU  - Gur RC
AD  - Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, 
      University of Pennsylvania, 10 Gates, 3400 Spruce Street, Philadelphia, PA 19104, 
      USA.
LA  - eng
GR  - P50 MH096891/MH/NIMH NIH HHS/United States
GR  - P50-MH096891/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150617
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Interview, Psychological
MH  - Male
MH  - Neuropsychological Tests
MH  - Prodromal Symptoms
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*psychology
MH  - Risk
MH  - Schizophrenia
MH  - Schizophrenic Psychology
MH  - Young Adult
PMC - PMC4512843
MID - NIHMS695741
OTO - NOTNLM
OT  - Clinical risk
OT  - Negative symptoms
OT  - Neurocognition
OT  - Psychosis
COIS- Conflict of interest Raquel E. Gur participated in an advisory board for Otsuka 
      unrelated to the study. All other authors declare no conflicts.
EDAT- 2015/06/22 06:00
MHDA- 2016/05/03 06:00
PMCR- 2016/08/01
CRDT- 2015/06/22 06:00
PHST- 2015/04/14 00:00 [received]
PHST- 2015/05/20 00:00 [revised]
PHST- 2015/05/22 00:00 [accepted]
PHST- 2015/06/22 06:00 [entrez]
PHST- 2015/06/22 06:00 [pubmed]
PHST- 2016/05/03 06:00 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - S0920-9964(15)00310-2 [pii]
AID - 10.1016/j.schres.2015.05.037 [doi]
PST - ppublish
SO  - Schizophr Res. 2015 Aug;166(1-3):322-7. doi: 10.1016/j.schres.2015.05.037. Epub 
      2015 Jun 17.