PMID- 26094301
OWN - NLM
STAT- MEDLINE
DCOM- 20150624
LR  - 20150622
IS  - 1066-2936 (Print)
IS  - 1066-2936 (Linking)
VI  - 42
IP  - 1
DP  - 2015 Jan-Feb
TI  - Expression changes of TNF-alpha, IL-1beta and IL-6 in the rat lung of decompression 
      sickness induced by fast buoyancy ascent escape.
PG  - 23-31
AB  - Fast buoyancy ascent escape is the general submarine escape manner adopted by the 
      majority of naval forces all over the world. However, if hyperbaric exposure time 
      exceeds the time limit, fast buoyancy ascent escape has a high risk to result in 
      decompression sickness (DCS). Tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta 
      (IL-1beta) and IL-6 have been all implicated in the process of inflammation 
      associated with acute lung injury (ALI). Our work demonstrated that DCS caused by 
      simulated fast buoyancy ascent escape could induce ALbeta in the rat model. The 
      purpose of the present work was to study the expression changes of TNF-alpha, IL-1beta 
      and IL-6 in the rat lung affected by DCS caused by simulated fast buoyancy ascent 
      escape. The lung tissue mRNA levels of TNF-alpha, Il-1beta and Il-6 were significantly 
      increased at 0.5 hour after DCS caused by simulated fast buoyancy ascent escape. 
      The lung contents of TNF-alpha, IL-1beta and IL-6 were at an expression peak at 0.5 
      hour, although showing no statistical difference when compared with the normal 
      control group. In conclusion, the rat lung expression variations of TNF-alpha, IL-1beta 
      and IL-6 are the most obvious at 0.5 hour within 24 hours after the lung injury 
      by DCS caused by simulated fast buoyancy ascent escape.
FAU - Wang, Hai-Tao
AU  - Wang HT
FAU - Fang, Yi-Qun
AU  - Fang YQ
FAU - Bao, Xiao-Chen
AU  - Bao XC
FAU - Yuan, Heng-Rong
AU  - Yuan HR
FAU - Ma, Jun
AU  - Ma J
FAU - Wang, Fang-Fang
AU  - Wang FF
FAU - Zhang, Shi
AU  - Zhang S
FAU - Li, Kai-Cheng
AU  - Li KC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Undersea Hyperb Med
JT  - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical 
      Society, Inc
JID - 9312954
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Acute Lung Injury/etiology/metabolism/pathology
MH  - Animals
MH  - Decompression Sickness/*metabolism/pathology
MH  - Interleukin-1beta/genetics/*metabolism
MH  - Interleukin-6/genetics/*metabolism
MH  - Lung/*metabolism/pathology
MH  - Male
MH  - RNA, Messenger/*metabolism
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Submarine Medicine
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/genetics/*metabolism
EDAT- 2015/06/23 06:00
MHDA- 2015/06/25 06:00
CRDT- 2015/06/23 06:00
PHST- 2015/06/23 06:00 [entrez]
PHST- 2015/06/23 06:00 [pubmed]
PHST- 2015/06/25 06:00 [medline]
PST - ppublish
SO  - Undersea Hyperb Med. 2015 Jan-Feb;42(1):23-31.