PMID- 26095634
OWN - NLM
STAT- MEDLINE
DCOM- 20160315
LR  - 20150623
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 86
IP  - 1
DP  - 2015 Jul
TI  - Association of HLA-DQA1 and -DQB1 alleles with type I diabetes in Arabs: a 
      meta-analyses.
PG  - 21-7
LID - 10.1111/tan.12598 [doi]
AB  - This study aimed at assessing the nature and significance of associations between 
      various alleles of HLA-DQA1, HLA-DQB1, and type I diabetes (T1D) in Arab 
      populations. Evidence from literature (published before 20 April 2015) was 
      amassed and analysed through multiple meta-analyses, which yielded effect summary 
      odds ratios and 95% confidence intervals for 24 alleles and 4 haplotypes. A total 
      of 1273 cases and 1747 controls from 16 studies were analysed. High levels of 
      significance were obtained to support higher T1D risk when harbouring DQA1*03:01. 
      The alleles DQB1*02:01 and *03:02 and the haplotypes DR3 and DR4 were significant 
      risk factors, albeit with high publication heterogeneity. The protective effects 
      of DQA1*01:01, DQB1*05:03, *06:02, *06:03, and *06:04 were robustly suggested by 
      all indicators of meta-analyses. The haplotypes DR7 and DR11 were strongly 
      suggested to be protective in Arabs. A relatively small number of studies have 
      emerged from Arab countries, mostly with inadequate power on an individual basis. 
      This study fills the gap by providing significant size effect of human leukocyte 
      antigen (HLA) alleles and completes the continuum of global ethnic differences in 
      this context.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Hamzeh, A R
AU  - Hamzeh AR
AD  - Centre for Arab Genomic Studies, Dubai, United Arab Emirates.
FAU - Nair, P
AU  - Nair P
AD  - Centre for Arab Genomic Studies, Dubai, United Arab Emirates.
FAU - Al-Khaja, N
AU  - Al-Khaja N
AD  - Centre for Arab Genomic Studies, Dubai, United Arab Emirates.
FAU - Al Ali, M T
AU  - Al Ali MT
AD  - Centre for Arab Genomic Studies, Dubai, United Arab Emirates.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Alleles
MH  - Arabs
MH  - Diabetes Mellitus, Type 1/*ethnology/*genetics/immunology/pathology
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ alpha-Chains/*genetics/immunology
MH  - HLA-DQ beta-Chains/*genetics/immunology
MH  - Haplotypes
MH  - Humans
MH  - Odds Ratio
MH  - Risk Factors
OTO - NOTNLM
OT  - Arabs
OT  - HLA-DQA
OT  - HLA-DQB
OT  - genetic susceptibility
OT  - type 1 diabetes mellitus
EDAT- 2015/06/23 06:00
MHDA- 2016/03/16 06:00
CRDT- 2015/06/23 06:00
PHST- 2015/03/08 00:00 [received]
PHST- 2015/05/19 00:00 [revised]
PHST- 2015/05/31 00:00 [accepted]
PHST- 2015/06/23 06:00 [entrez]
PHST- 2015/06/23 06:00 [pubmed]
PHST- 2016/03/16 06:00 [medline]
AID - 10.1111/tan.12598 [doi]
PST - ppublish
SO  - Tissue Antigens. 2015 Jul;86(1):21-7. doi: 10.1111/tan.12598.