PMID- 26095722
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20191210
IS  - 1467-2995 (Electronic)
IS  - 1467-2987 (Linking)
VI  - 43
IP  - 2
DP  - 2016 Mar
TI  - Evaluation of the non-calibrated pulse contour cardiac output monitor 
      FloTrac/Vigileo against thermodilution in standing horses.
PG  - 153-62
LID - 10.1111/vaa.12281 [doi]
AB  - OBJECTIVE: To evaluate the non-calibrated, minimally invasive cardiac output (CO) 
      monitor FloTrac/Vigileo (FloTrac) against thermodilution (TD) CO in standing 
      horses. STUDY DESIGN: Prospective, experimental trial. ANIMALS: Nine adult horses 
      weighing a median (range) of 535 (470-602) kg. METHODS: Catheters were placed in 
      the right atrium, pulmonary artery and carotid artery under local anaesthesia. CO 
      was measured 147 times by TD and FloTrac and indexed to body weight. Changes in 
      CO were achieved with romifidine or xylazine and dobutamine constant rate 
      infusions. Bland-Altman analysis, concordance and polar plot analysis were used 
      to assess agreement and ability to track changes in CO. RESULTS: Mean +/- standard 
      deviation COTD of 48 +/- 16 mL kg(-1) minute(-1) (range: 19-93 mL kg(-1) minute(-1) 
      ) and mean COF loTrac of 9 +/- 3 mL kg(-1) minute(-1) (range: 5-21 mL kg(-1) 
      minute(-1) ) were measured. Low agreement with a large mean bias of 39 mL kg(-1) 
      minute(-1) and wide limits of agreement of 8-70 mL kg(-1) minute(-1) were found. 
      The percentage error of 108% and precision of TD of +/- 18% resulted in an 
      estimated precision of FloTrac of +/- 106%. Comparison of changes in COF loTrac 
      with changes in COTD gave a concordance rate of 52% in the four-quadrant plot, 
      and a mean polar angle of -11 degrees  with radial limits of agreement of +/- 61  degrees  in the 
      polar plot. Mean arterial pressure (MAP) and COF loTrac were positively 
      correlated (r = 0.5, p < 0.0001). No correlation of MAP with COTD was observed. 
      CONCLUSIONS AND CLINICAL RELEVANCE: The FloTrac system, originally designed for 
      use in humans, neither measured absolute CO in standing horses accurately nor 
      tracked relative changes in CO measured by TD correctly. The false dependence of 
      COF loTrac on arterial blood pressure further discourages the use of this 
      technique in horses.
CI  - (c) 2015 Association of Veterinary Anaesthetists and the American College of 
      Veterinary Anesthesia and Analgesia.
FAU - Kutter, Annette P N
AU  - Kutter AP
AD  - Section of Anaesthesiology, Equine Department, Vetsuisse Faculty, University of 
      Zurich, Zurich, Switzerland.
FAU - Bettschart-Wolfensberger, Regula
AU  - Bettschart-Wolfensberger R
AD  - Section of Anaesthesiology, Equine Department, Vetsuisse Faculty, University of 
      Zurich, Zurich, Switzerland.
FAU - Schwarzwald, Colin C
AU  - Schwarzwald CC
AD  - Clinic for Equine Internal Medicine, Equine Department, Vetsuisse Faculty, 
      University of Zurich, Zurich, Switzerland.
FAU - Portier, Karine G
AU  - Portier KG
AD  - Section of Anaesthesiology, VetAgro Sup (Veterinary Campus), University of Lyon, 
      Marcy L'Etoile, France.
AD  - INSERM (Institut National de la Sante et de la Recherche Medicale), UMR-1060, 
      CarMeN (Cardiovasculaire, Metabolisme, Diabetologie et Nutrition), Lyon, France.
FAU - Ringer, Simone K
AU  - Ringer SK
AD  - Section of Anaesthesiology, Equine Department, Vetsuisse Faculty, University of 
      Zurich, Zurich, Switzerland.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150611
PL  - United States
TA  - Vet Anaesth Analg
JT  - Veterinary anaesthesia and analgesia
JID - 100956422
RN  - 0 (Adrenergic alpha-2 Receptor Agonists)
RN  - 0 (Adrenergic beta-1 Receptor Agonists)
RN  - 0 (Anesthetics)
RN  - 0 (Imidazoles)
RN  - 2KFG9TP5V8 (Xylazine)
RN  - 3S12J47372 (Dobutamine)
RN  - 876351L05K (romifidine)
SB  - IM
MH  - Adrenergic alpha-2 Receptor Agonists/administration & dosage
MH  - Adrenergic beta-1 Receptor Agonists/administration & dosage
MH  - Anesthesia/*veterinary
MH  - Anesthetics/administration & dosage
MH  - Animals
MH  - Blood Pressure
MH  - Calibration
MH  - *Cardiac Output
MH  - Dobutamine/administration & dosage
MH  - Female
MH  - Heart Function Tests/instrumentation/*veterinary
MH  - *Horses
MH  - Imidazoles/administration & dosage
MH  - Male
MH  - Monitoring, Physiologic/methods/*veterinary
MH  - Thermodilution
MH  - Xylazine/administration & dosage
OTO - NOTNLM
OT  - FloTrac/Vigileo
OT  - cardiac output measurement
OT  - horses
OT  - pulse contour analysis
OT  - thermodilution cardiac output
EDAT- 2015/06/23 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/06/23 06:00
PHST- 2014/10/08 00:00 [received]
PHST- 2015/02/10 00:00 [accepted]
PHST- 2015/06/23 06:00 [entrez]
PHST- 2015/06/23 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S1467-2987(16)30052-6 [pii]
AID - 10.1111/vaa.12281 [doi]
PST - ppublish
SO  - Vet Anaesth Analg. 2016 Mar;43(2):153-62. doi: 10.1111/vaa.12281. Epub 2015 Jun 
      11.